PMID- 35979932
OWN - NLM
STAT- MEDLINE
DCOM- 20220914
LR  - 20220914
IS  - 1477-9234 (Electronic)
IS  - 1477-9226 (Linking)
VI  - 51
IP  - 35
DP  - 2022 Sep 13
TI  - Two cationic iron-based crystalline porous materials for encapsulation and 
      sustained release of 5-fluorouracil.
PG  - 13263-13271
LID - 10.1039/d2dt01854c [doi]
AB  - Iron-based crystalline porous materials (CPMs) emerged as a new class of 
      biodegradable and non-toxic materials of high interest for drug delivery systems 
      (DDSs) due to their high loading capacity and controllable structures. This work 
      constructed two kinds of Fe-CPM coordination polymers (CPM-83 and CPM-85) from 
      typical oxo-centered trimers of the iron octahedra cluster [Fe(3)O(RCOO)(3)(TPT)] 
      with two functional modules. The tri-topic pyridine ligand (TPT) occupied the 
      open metal sites of the trinuclear cluster, precluding the attachment of 
      neutralizing anions, leading to three-dimensional frameworks with a positive 
      charge and higher stability. Moreover, the triazine ligand TPT divides the 
      original columnar channel into small domains, improving the adsorption efficiency 
      and maximizing the host-guest interaction. Hence, the suitable pore size and 
      electrostatic force make the materials highly adsorption selective for the 
      anticancer drug 5-fluorouracil (5-Fu). We show that Fe-CPM-83 and Fe-CPM-85 
      loaded with 5-Fu are efficient drug delivery vehicles with loading content as 
      high as 60.5 (wt%) and 32.8 (wt%) within 2-5 h of loading time. Simultaneously, 
      their sustained release kinetics can be up to 96 hours with a completely 
      different pH-responsive controlled release. The released content is 77% or 85% 
      for each complex, significantly prolonging the release process and decreasing the 
      plasma concentration. The MTT assay was performed on mouse fibroblasts (L929) to 
      demonstrate the satisfactory biocompatibility of the matrix. This work has 
      momentous research significance and application value for developing novel 
      drug-delivery materials.
FAU - Sun, Xi-Yu
AU  - Sun XY
AD  - School of Chemistry and Molecular Engineering, East China Normal University, 
      Shanghai, 200241, P. R. China. xsun@chem.ecnu.edu.cn.
FAU - Zhang, Hong-Jing
AU  - Zhang HJ
AD  - School of Chemistry and Molecular Engineering, East China Normal University, 
      Shanghai, 200241, P. R. China. xsun@chem.ecnu.edu.cn.
FAU - Sun, Qian
AU  - Sun Q
AUID- ORCID: 0000-0001-8549-0093
AD  - School of Chemistry and Molecular Engineering, East China Normal University, 
      Shanghai, 200241, P. R. China. xsun@chem.ecnu.edu.cn.
FAU - Gao, En-Qing
AU  - Gao EQ
AUID- ORCID: 0000-0002-5631-2391
AD  - Shanghai Key Laboratory of Green Chemistry and Chemical Processes, School of 
      Chemistry and Molecular Engineering, East China Normal University, Shanghai 
      200062, P. R. China.
LA  - eng
PT  - Journal Article
DEP - 20220913
PL  - England
TA  - Dalton Trans
JT  - Dalton transactions (Cambridge, England : 2003)
JID - 101176026
RN  - 0 (Delayed-Action Preparations)
RN  - 0 (Ligands)
RN  - E1UOL152H7 (Iron)
RN  - U3P01618RT (Fluorouracil)
SB  - IM
MH  - Animals
MH  - Delayed-Action Preparations/pharmacology
MH  - *Fluorouracil/chemistry/pharmacology
MH  - *Iron/chemistry
MH  - Ligands
MH  - Mice
MH  - Porosity
EDAT- 2022/08/19 06:00
MHDA- 2022/09/15 06:00
CRDT- 2022/08/18 06:22
PHST- 2022/08/19 06:00 [pubmed]
PHST- 2022/09/15 06:00 [medline]
PHST- 2022/08/18 06:22 [entrez]
AID - 10.1039/d2dt01854c [doi]
PST - epublish
SO  - Dalton Trans. 2022 Sep 13;51(35):13263-13271. doi: 10.1039/d2dt01854c.