PMID- 35981338
OWN - NLM
STAT- MEDLINE
DCOM- 20220822
LR  - 20220822
IS  - 0042-8787 (Print)
IS  - 0042-8787 (Linking)
VI  - 99
IP  - 4
DP  - 2022
TI  - [Complex effects of physical exertion with dietary supplements Cartilox in pain 
      syndrome effectiveness and safety evaluation].
PG  - 20-28
LID - 10.17116/kurort20229904120 [doi]
AB  - A promising direction of osteoarthritis (OA) therapy is currently being 
      considered pharmaceutical compositions of Symptomatic Slow Acting Drugs for 
      Osteoarthritis (SYSADOA), which include type II collagen. A clinical 
      observational study was conducted. OBJECTIVE: To Identify the effect of physical 
      activity complex effects with dietary supplements Cartilox (composition: 
      hydrolyzed type II collagen, hyaluronic acid, boswellia, curcumin, piperine) on 
      the severity of pain syndrome in OA knee and hip joint patients, low back pain 
      (LBP); assessment of the need for the appointment of NSAIDs against the 
      background of taking Cartilox. MATERIAL AND METHODS: The study included 60 
      patients aged 35-65 years, with a confirmed diagnosis of knee and hip OA I-II 
      st., LBP with a slight degree of severity of pain syndrome - 4-5 points on a 
      numerical rating scale (NRS). Patients with comorbid diseases: arterial 
      hypertension (AH), type 2 diabetes mellitus (DM-2), hypothyroidism, diseases of 
      the gastrointestinal tract (gastrointestinal tract). By randomization, the 
      patients were divided into two groups: Main group (n=30; 54.36+/-8.57 years) 
      received a complex effect of non-drug therapy (physical therapy complex) with 
      dietary supplements Cartilox 1 sachet per day during or immediately after meals 
      for 1 month, in combination with non-medical therapy (physical therapy complex). 
      And Control group (n=30; 53.03+/-16.18 years) used only non-medical therapy 
      (physical therapy complex). In both groups, topical NSAIDs were used <<on demand>>. 
      The patients included in the study had imaging data of the spine and joints. 
      Clinical and neurological examination was used: day 0 (Visit 1), Day 14 (Visit 
      2), Day 30 (Visit 3) of therapy. The dynamics of the condition was assessed: 
      10-point NRS of pain assessment (at rest, while walking, palpation), functional 
      status of Oswestry Disability Index (ODI), blood pressure (BP) was measured, the 
      dynamics of biochemical parameters (before and after 30 days) of blood glucose, 
      liver enzymes (AST, ALT), weight indicators, registration of adverse events 
      (AEs). A sub-objective assessment (1 to 5 balls) was given to the patient and the 
      physician. RESULTS: Against the background of taking Cartilox, a statistically 
      significant decrease in the severity of pain syndrome was noted, an improvement 
      on ODI (to a greater extent in the Main group vs the Control group). In no case 
      has a registered AEs. Changes in the level of biochemical blood parameters 
      (glucose, liver enzymes) and blood pressure levels were not observed. The topical 
      NSAIDs use was observed only in the Control group. CONCLUSION: The complex effect 
      of physical exertion with dietary supplements Cartilox can be recommended for 
      patients with unexpressed pain syndrome (4-5 points on the NRS) with LBP and knee 
      and hip OA (I-II st.). The absence of changes in the level of biochemical 
      parameters of blood and blood pressure makes it possible to recommend Cartilox to 
      patients with OA and comorbid diseases.
FAU - Shavlovskaya, O A
AU  - Shavlovskaya OA
AUID- ORCID: 0000-0003-3726-0730
AD  - International University of Restorative Medicine, Moscow, Russia.
LA  - rus
PT  - Journal Article
PT  - Observational Study
TT  - Otsenka effektivnosti i bezopasnosti kompleksnogo vozdeistviya fizicheskikh 
      nagruzok s BAD Kartiloks pri bolevom sindrome.
PL  - Russia (Federation)
TA  - Vopr Kurortol Fizioter Lech Fiz Kult
JT  - Voprosy kurortologii, fizioterapii, i lechebnoi fizicheskoi kultury
JID - 2984868R
RN  - 0 (Anti-Inflammatory Agents, Non-Steroidal)
RN  - 0 (Collagen Type II)
SB  - IM
MH  - Anti-Inflammatory Agents, Non-Steroidal/therapeutic use
MH  - Collagen Type II/therapeutic use
MH  - *Diabetes Mellitus, Type 2/drug therapy
MH  - Dietary Supplements
MH  - Humans
MH  - *Low Back Pain/drug therapy
MH  - *Osteoarthritis, Hip
MH  - *Osteoarthritis, Knee/drug therapy
MH  - Physical Exertion
OTO - NOTNLM
OT  - Cartilox
OT  - boswellia
OT  - curcumin
OT  - hip osteoarthritis
OT  - hyaluronic acid
OT  - hydrolyzed type II collagen
OT  - knee osteoarthritis
OT  - low back pain
OT  - osteoarthritis
OT  - piperine
EDAT- 2022/08/19 06:00
MHDA- 2022/08/23 06:00
CRDT- 2022/08/18 17:46
PHST- 2022/08/18 17:46 [entrez]
PHST- 2022/08/19 06:00 [pubmed]
PHST- 2022/08/23 06:00 [medline]
AID - 10.17116/kurort20229904120 [doi]
PST - ppublish
SO  - Vopr Kurortol Fizioter Lech Fiz Kult. 2022;99(4):20-28. doi: 
      10.17116/kurort20229904120.