PMID- 35983222
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220820
IS  - 1756-283X (Print)
IS  - 1756-2848 (Electronic)
IS  - 1756-283X (Linking)
VI  - 15
DP  - 2022
TI  - Mean nocturnal baseline impedance, a novel metric of multichannel intraluminal 
      impedance-pH monitoring in diagnosing gastroesophageal reflux disease.
PG  - 17562848221105195
LID - 10.1177/17562848221105195 [doi]
LID - 17562848221105195
AB  - Gastroesophageal reflux disease (GERD) is a common disease with increasing 
      prevalence worldwide. However, the diagnosis of GERD is challenging because there 
      are no definite gold standard criteria. Recently, a novel impedance parameter, 
      namely mean nocturnal baseline impedance (MNBI), has been proposed, which 
      reflects the burden of longitudinal reflux and the integrity of esophageal 
      mucosa. MNBI has shown an immense promise for increasing the diagnostic rate of 
      multichannel intraluminal impedance-pH (MII-pH) monitoring and predicting the 
      response to proton pump inhibitor (PPI) or anti-reflux intervention in patients 
      with reflux symptoms. The present paper reviews the association between baseline 
      impedance and esophageal mucosal integrity, the acquisition of MNBI in 24-h 
      MII-pH monitoring, the clinical utilization of MNBI in improving the diagnosis 
      rate of GERD in patients with typical reflux symptoms, predicting the response to 
      PPI or anti-reflux treatment in these patients, the utilization of MNBI in 
      diagnosing patients with atypical symptoms or extra-esophageal symptoms, and the 
      correlation between reflux burden and MNBI. MNBI should be routinely assessed 
      using MII-pH monitoring.
CI  - (c) The Author(s), 2022.
FAU - Wu, Yanhong
AU  - Wu Y
AD  - Department of Gastroenterology, Beijing Tong Ren Hospital, Capital Medical 
      University, Beijing, P. R. China.
FAU - Guo, Zihao
AU  - Guo Z
AD  - Department of Gastroenterology, Beijing Tong Ren Hospital, Capital Medical 
      University, Beijing, P. R. China.
FAU - Zhang, Chuan
AU  - Zhang C
AD  - Department of Gastroenterology, Beijing Tong Ren Hospital, Capital Medical 
      University, No.1, Dongjiaominxiang, Dongcheng District, Beijing 100730, P. R. 
      China.
FAU - Zhan, Yutao
AU  - Zhan Y
AUID- ORCID: 0000-0003-2800-3599
AD  - Department of Gastroenterology, Beijing Tong Ren Hospital, Capital Medical 
      University, No.1, Dongjiaominxiang, Dongcheng District, Beijing 100730, P. R. 
      China.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20220811
PL  - England
TA  - Therap Adv Gastroenterol
JT  - Therapeutic advances in gastroenterology
JID - 101478893
PMC - PMC9379274
OTO - NOTNLM
OT  - gastroesophageal reflux disease
OT  - mean nocturnal baseline impedance
OT  - multichannel intraluminal impedance-pH monitoring
COIS- Competing Interests: The authors declare that there is no conflict of interest.
EDAT- 2022/08/20 06:00
MHDA- 2022/08/20 06:01
PMCR- 2022/08/11
CRDT- 2022/08/19 02:16
PHST- 2021/09/26 00:00 [received]
PHST- 2022/05/18 00:00 [accepted]
PHST- 2022/08/19 02:16 [entrez]
PHST- 2022/08/20 06:00 [pubmed]
PHST- 2022/08/20 06:01 [medline]
PHST- 2022/08/11 00:00 [pmc-release]
AID - 10.1177_17562848221105195 [pii]
AID - 10.1177/17562848221105195 [doi]
PST - epublish
SO  - Therap Adv Gastroenterol. 2022 Aug 11;15:17562848221105195. doi: 
      10.1177/17562848221105195. eCollection 2022.