PMID- 35984038
OWN - NLM
STAT- MEDLINE
DCOM- 20220908
LR  - 20220908
IS  - 1944-8252 (Electronic)
IS  - 1944-8244 (Linking)
VI  - 14
IP  - 34
DP  - 2022 Aug 31
TI  - PDMS-PEG Block Copolymer and Pretreatment for Arresting Drug Absorption in 
      Microphysiological Devices.
PG  - 38541-38549
LID - 10.1021/acsami.2c10669 [doi]
AB  - Poly(dimethylsiloxane) (PDMS) is a commonly used polymer in organ-on-a-chip 
      devices and microphysiological systems. However, due to its hydrophobicity and 
      permeability, it absorbs drug compounds, preventing accurate drug screening 
      applications. Here, we developed an effective and facile method to prevent the 
      absorption of drugs by utilizing a PDMS-PEG block copolymer additive and drug 
      pretreatment. First, we incorporated a PDMS-PEG block copolymer into PDMS to 
      address its inherent hydrophobicity. Next, we addressed the permeability of PDMS 
      by eliminating the concentration gradient via pretreatment of the PDMS with the 
      drug prior to experimentally testing drug absorption. The combined use of a 
      PDMS-PEG block copolymer with drug pretreatment resulted in a mean reduction of 
      drug absorption by 91.6% in the optimal condition. Finally, we demonstrated that 
      the proposed method can be applied to prevent drug absorption in a PDMS-based 
      cardiac microphysiological system, enabling more accurate drug studies.
FAU - Mair, Devin B
AU  - Mair DB
AD  - Department of Biomedical Engineering, Johns Hopkins University School of 
      Medicine, Baltimore, Maryland 21205, United States.
FAU - Williams, Marcus Alonso Cee
AU  - Williams MAC
AD  - Department of Biomedical Engineering, Johns Hopkins University School of 
      Medicine, Baltimore, Maryland 21205, United States.
FAU - Chen, Jeffrey Fanzhi
AU  - Chen JF
AD  - Department of Biomedical Engineering, Johns Hopkins University School of 
      Medicine, Baltimore, Maryland 21205, United States.
FAU - Goldstein, Alex
AU  - Goldstein A
AD  - Institute for Stem Cell and Regenerative Medicine, University of Washington, 
      Seattle, Washington 98195, United States.
AD  - Department of Laboratory Medicine and Pathology, University of Washington, 
      Seattle, Washington 98195, United States.
AD  - Department of Material Science and Engineering, University of Washington, 
      Seattle, Washington 98195, United States.
FAU - Wu, Alex
AU  - Wu A
AD  - Department of Biomedical Engineering, Johns Hopkins University School of 
      Medicine, Baltimore, Maryland 21205, United States.
FAU - Lee, Peter H U
AU  - Lee PHU
AD  - Department of Pathology and Laboratory Medicine, Brown University, Providence, 
      Rhode Island 02912, United States.
FAU - Sniadecki, Nathan J
AU  - Sniadecki NJ
AUID- ORCID: 0000-0001-6960-4492
AD  - Institute for Stem Cell and Regenerative Medicine, University of Washington, 
      Seattle, Washington 98195, United States.
AD  - Department of Laboratory Medicine and Pathology, University of Washington, 
      Seattle, Washington 98195, United States.
AD  - Department of Mechanical Engineering, University of Washington, Seattle, 
      Washington 98195, United States.
AD  - Department of Bioengineering, University of Washington, Seattle, Washington 
      98195, United States.
FAU - Kim, Deok-Ho
AU  - Kim DH
AUID- ORCID: 0000-0002-6989-6074
AD  - Department of Biomedical Engineering, Johns Hopkins University School of 
      Medicine, Baltimore, Maryland 21205, United States.
AD  - Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, 
      Maryland 21205, United States.
LA  - eng
PT  - Journal Article
DEP - 20220819
PL  - United States
TA  - ACS Appl Mater Interfaces
JT  - ACS applied materials & interfaces
JID - 101504991
RN  - 0 (Dimethylpolysiloxanes)
RN  - 0 (Polymers)
SB  - IM
MH  - *Dimethylpolysiloxanes
MH  - Drug Evaluation, Preclinical
MH  - Hydrophobic and Hydrophilic Interactions
MH  - Permeability
MH  - *Polymers
OTO - NOTNLM
OT  - PDMS
OT  - PDMS-PEG
OT  - drug absorption
OT  - microphysiological systems
OT  - organ-on-a-chip
EDAT- 2022/08/20 06:00
MHDA- 2022/09/09 06:00
CRDT- 2022/08/19 08:04
PHST- 2022/08/20 06:00 [pubmed]
PHST- 2022/09/09 06:00 [medline]
PHST- 2022/08/19 08:04 [entrez]
AID - 10.1021/acsami.2c10669 [doi]
PST - ppublish
SO  - ACS Appl Mater Interfaces. 2022 Aug 31;14(34):38541-38549. doi: 
      10.1021/acsami.2c10669. Epub 2022 Aug 19.