PMID- 35985442
OWN - NLM
STAT- MEDLINE
DCOM- 20221216
LR  - 20221222
IS  - 1873-6963 (Electronic)
IS  - 0965-2299 (Linking)
VI  - 71
DP  - 2022 Dec
TI  - The effectiveness and safety of acupuncture treatment on sciatica: A systematic 
      review and meta-analysis.
PG  - 102872
LID - S0965-2299(22)00074-7 [pii]
LID - 10.1016/j.ctim.2022.102872 [doi]
AB  - BACKGROUND: Sciatica results from primary or secondary damage to the sciatic 
      nerve in the lumbar or gluteal region. The first option for sciatica is 
      analgesics, but their therapeutic effect and safety in long-term use are 
      questionable. On the other hand, acupuncture has recently been recognized as a 
      complementary and alternative medicine (CAM) to conventional medicine, and 
      studies on its effectiveness and safety have been actively conducted. OBJECTIVE: 
      To systematically compare acupuncture with analgesics in terms of effect, safety, 
      and durability in the treatment of sciatica METHODS: This review was performed in 
      accordance with Cochrane Handbook for Systematic Reviews of Interventions Version 
      6.2. Four databases were searched for this review: Wangfang, the Korean 
      Traditional Knowledge Portal (KTKP), PubMed, and EBSCOhost. The primary outcome 
      measures in the review were total effective rate (TER), visual analog scale (VAS) 
      score and pain threshold, and the secondary ones were adverse effects (AEs) and 
      relapse rates. Risk ratio (RR) for TER and mean difference (MD) for VAS score and 
      pain threshold were used as statistics for the meta-analysis of effectiveness, 
      along with associated 95 % confidence intervals (CIs) and P-values. AEs and 
      relapse rates were used for the safety and durability of the interventions. 
      Version 2 of the Cochrane risk-of-bias assessment tool for randomized trials (RoB 
      2) was used for the methodological quality of randomized controlled trials (RCTs) 
      included in the review. RESULTS: The synthesized TER of 28 RCTs involving 2707 
      participants was significantly higher in the acupuncture group compared to the 
      analgesic group (RR [95 % CI] = 1.20 [1.16, 1.24], P < 0.001). The synthesized 
      VAS score of 7 RCTs involving 589 participants was significantly reduced in the 
      acupuncture group compared to the analgesic group (MD [95 % CI] = - 1.78 [- 2.44, 
      - 1.12], P < 0.001). In 5 RCTs involving 311 participants, the synthesized pain 
      threshold was significantly elevated in the acupuncture group compared to the 
      analgesic group (MD [95 % CI] = 0.93 [0.64, 1.22], P < 0.001). Additionally, 
      adverse effects (AEs) and relapse rates of RCTs in the review were lower in the 
      acupuncture group compared to the analgesic group. CONCLUSION: In this systematic 
      review, acupuncture treatment was significantly effective and safe compared to 
      analgesics in sciatica. In the future, studies with a rigorous study design are 
      required to increase the validity of the effectiveness and safety of acupuncture 
      treatment for sciatica.
CI  - Copyright (c) 2022 The Authors. Published by Elsevier Ltd.. All rights reserved.
FAU - Han, Kyou-Hwan
AU  - Han KH
AD  - SBU Research Institute of Integrative Medicine, South Baylo University, 2727 West 
      6th Street, Los Angeles, CA 90057, USA. Electronic address: 
      kyouhwan2013@gmail.com.
FAU - Cho, Ki Haeng
AU  - Cho KH
AD  - SBU Research Institute of Integrative Medicine, South Baylo University, 2727 West 
      6th Street, Los Angeles, CA 90057, USA.
FAU - Han, Caroline
AU  - Han C
AD  - SBU Research Institute of Integrative Medicine, South Baylo University, 2727 West 
      6th Street, Los Angeles, CA 90057, USA.
FAU - Cui, Shanqin
AU  - Cui S
AD  - SBU Research Institute of Integrative Medicine, South Baylo University, 2727 West 
      6th Street, Los Angeles, CA 90057, USA.
FAU - Lin, Lily
AU  - Lin L
AD  - SBU Research Institute of Integrative Medicine, South Baylo University, 2727 West 
      6th Street, Los Angeles, CA 90057, USA.
FAU - Baek, Ho-Yu
AU  - Baek HY
AD  - School of Big Data and Financial Statistics, Wonkwang University, 460 Iksandaero, 
      Iksan, Jeonbuk 54538, the Republic of Korea.
FAU - Kim, Jaejong
AU  - Kim J
AD  - SBU Research Institute of Integrative Medicine, South Baylo University, 2727 West 
      6th Street, Los Angeles, CA 90057, USA.
LA  - eng
PT  - Journal Article
PT  - Meta-Analysis
PT  - Systematic Review
DEP - 20220817
PL  - Scotland
TA  - Complement Ther Med
JT  - Complementary therapies in medicine
JID - 9308777
RN  - 0 (Analgesics)
SB  - IM
MH  - Humans
MH  - Neoplasm Recurrence, Local/drug therapy
MH  - *Acupuncture Therapy/adverse effects/methods
MH  - Analgesics/therapeutic use
MH  - *Complementary Therapies
MH  - *Sciatica/therapy
OTO - NOTNLM
OT  - A systematic review and meta-analysis
OT  - Acupuncture treatment
OT  - Analgesic
OT  - Randomized controlled trial
OT  - Sciatica
COIS- Conflict of Interest Disclosures No disclosures were reported.
EDAT- 2022/08/20 06:00
MHDA- 2022/12/15 06:00
CRDT- 2022/08/19 19:24
PHST- 2022/04/28 00:00 [received]
PHST- 2022/07/28 00:00 [revised]
PHST- 2022/08/15 00:00 [accepted]
PHST- 2022/08/20 06:00 [pubmed]
PHST- 2022/12/15 06:00 [medline]
PHST- 2022/08/19 19:24 [entrez]
AID - S0965-2299(22)00074-7 [pii]
AID - 10.1016/j.ctim.2022.102872 [doi]
PST - ppublish
SO  - Complement Ther Med. 2022 Dec;71:102872. doi: 10.1016/j.ctim.2022.102872. Epub 
      2022 Aug 17.