PMID- 35985767
OWN - NLM
STAT- MEDLINE
DCOM- 20220913
LR  - 20221117
IS  - 1945-4589 (Electronic)
IS  - 1945-4589 (Linking)
VI  - 14
IP  - 16
DP  - 2022 Aug 18
TI  - Transcriptomic signature associated with RNA-binding proteins for survival 
      stratification of laryngeal cancer.
PG  - 6605-6625
LID - 10.18632/aging.204234 [doi]
AB  - RNA-binding proteins (RBPs) have been suggested as important prognostic 
      indicators in different human cancers. This study was designed to search the 
      prognostic value of RBPs of laryngeal squamous cell carcinoma (LSCC). 
      Differentially expressed RBPs (DERBPs) were screened via The Cancer Genome Atlas 
      (TCGA). Bioinformatics methods were used to identify prognostic DERBPs. 
      Expression profiling of training cohort were calculated to develop a 
      transcriptomic signature, which was validated by three independent cohorts (TCGA 
      cohort, GSE65858 cohort and GSE27020 cohort). We identified DERBPs and a set of 
      signatures (GTPBP3, KHDRBS3 and RBM38) were confirmed as prognosis-related hub 
      DERBPs in LSCC, which was also tested and verified by bioinformatics method and 
      molecular biology experiment. The role of immune cell infiltration and drug 
      resistance between subgroups was explored. Furthermore, the risk score based on 
      transcriptomic signature was turned out to be an independent prognostic indicator 
      for LSCC. Finally, a nomogram for further clinical application was established. 
      Our study demonstrated that the transcriptomic signature we constructed could 
      serve as a novel therapeutic target and biomarker for LSCC from the perspective 
      of RBPs.
FAU - Shen, Yujie
AU  - Shen Y
AD  - Department of Otorhinolaryngology Head and Neck Surgery, Eye, Ear, Nose, and 
      Throat Hospital, Fudan University, Shanghai 200031, Shanghai, China.
FAU - Chen, Huijun
AU  - Chen H
AD  - Department of Otolaryngology Head and Neck Surgery, Zhongda Hospital, Southeast 
      University, Nanjing 210009, Jiangsu, China.
FAU - Huang, Qiang
AU  - Huang Q
AD  - Department of Otorhinolaryngology Head and Neck Surgery, Eye, Ear, Nose, and 
      Throat Hospital, Fudan University, Shanghai 200031, Shanghai, China.
FAU - Du, Huaidong
AU  - Du H
AD  - Department of Otorhinolaryngology Head and Neck Surgery, Eye, Ear, Nose, and 
      Throat Hospital, Fudan University, Shanghai 200031, Shanghai, China.
FAU - Zhou, Liang
AU  - Zhou L
AD  - Department of Otorhinolaryngology Head and Neck Surgery, Eye, Ear, Nose, and 
      Throat Hospital, Fudan University, Shanghai 200031, Shanghai, China.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20220818
PL  - United States
TA  - Aging (Albany NY)
JT  - Aging
JID - 101508617
RN  - 0 (Biomarkers, Tumor)
RN  - 0 (KHDRBS3 protein, human)
RN  - 0 (RBM38 protein, human)
RN  - 0 (RNA-Binding Proteins)
RN  - EC 3.6.1.- (GTP-Binding Proteins)
RN  - EC 3.6.1.- (GTPBP3 protein, human)
SB  - IM
MH  - Biomarkers, Tumor/genetics/metabolism
MH  - GTP-Binding Proteins/genetics
MH  - *Head and Neck Neoplasms
MH  - Humans
MH  - *Laryngeal Neoplasms/genetics
MH  - Prognosis
MH  - RNA-Binding Proteins/genetics/metabolism
MH  - Squamous Cell Carcinoma of Head and Neck
MH  - Transcriptome
PMC - PMC9467394
OTO - NOTNLM
OT  - RNA-binding proteins
OT  - laryngeal squamous cell carcinoma
OT  - overall survival
OT  - prognosis
OT  - signature
COIS- CONFLICTS OF INTEREST: The authors declare that there are no potential conflicts 
      of interest.
EDAT- 2022/08/20 06:00
MHDA- 2022/09/14 06:00
PMCR- 2022/08/31
CRDT- 2022/08/19 21:05
PHST- 2022/03/11 00:00 [received]
PHST- 2022/08/03 00:00 [accepted]
PHST- 2022/08/20 06:00 [pubmed]
PHST- 2022/09/14 06:00 [medline]
PHST- 2022/08/19 21:05 [entrez]
PHST- 2022/08/31 00:00 [pmc-release]
AID - 204234 [pii]
AID - 10.18632/aging.204234 [doi]
PST - ppublish
SO  - Aging (Albany NY). 2022 Aug 18;14(16):6605-6625. doi: 10.18632/aging.204234. Epub 
      2022 Aug 18.