PMID- 35987017
OWN - NLM
STAT- MEDLINE
DCOM- 20220830
LR  - 20220830
IS  - 1618-095X (Electronic)
IS  - 0944-7113 (Linking)
VI  - 105
DP  - 2022 Oct
TI  - p-hydroxy benzaldehyde revitalizes the microenvironment of peri-infarct cortex in 
      rats after cerebral ischemia-reperfusion.
PG  - 154379
LID - S0944-7113(22)00458-5 [pii]
LID - 10.1016/j.phymed.2022.154379 [doi]
AB  - BACKGROUND: The formation of glial scar around the ischemic core following 
      cerebral blood interruption exerts a protective effect in the subacute phase but 
      impedes neurorepair in the chronic phase. Therefore, the present study aimed to 
      explore whether p-hydroxy benzaldehyde (p-HBA), a phenolic compound isolated from 
      Gastrodia elata Blume, can cut the Gordian knot of glial scar and promote brain 
      repair after cerebral ischemia. METHODS: The effects of p-HBA on neurorepair were 
      evaluated using a rat model of transient middle cerebral artery occlusion 
      (tMCAO). The motor functions were evaluated by neurobehavioral tests, the 
      pathophysiological processes in the peri-infarct cortex (PIC) were detected by 
      viral-based lineage tracking or immunofluorescence staining, and the putative 
      signaling pathway was analyzed by western blot. RESULTS: Administration of p-HBA 
      in the acute stage after stroke onset alleviated the motor impairment in tMCAO 
      rats in a time-dependent manner. The corresponding cellular events were 
      inhibition of astrogliosis, facilitating the conversion of reactive astrocytes 
      (RAs) into neurons, and prompting angiogenesis in PIC, thereby protecting the 
      structure of the neurovascular unit (NVU). One of the underlying molecular 
      mechanisms is the activation of the neurogenic switch of the Wnt/beta-catenin 
      signaling pathway. Notably, p-HBA only promotes astrocyte-to-neuron conversion in 
      the PIC, and only partial RAs were converted to neurons. This pattern of 
      conversion ensures that the brain structure remains unaltered, and the beneficial 
      role of glial scarring is preserved during the subacute phase after ischemia. 
      CONCLUSIONS: These results provided a potential approach to address the dilemma 
      of glial scarring after brain injury, i.e., the pharmacological promotion of 
      astrocyte-to-neuron conversion in the PIC without interfering with normal brain 
      tissue, which mitigates but does not eliminate the glial scar. Subsequently, the 
      neuron rescue-unfriendly environment is switched to a beneficial reconstruction 
      milieu in PIC, which is conducive to neurorepair. Moreover, p-HBA could be a 
      candidate for pharmacological intervention.
CI  - Copyright (c) 2022. Published by Elsevier GmbH.
FAU - Yuan, Yajin
AU  - Yuan Y
AD  - College of Chinese Materia Medica and Yunnan Key Laboratory of Southern Medicinal 
      Utilization, Yunnan University of Chinese Medicine, 1076 Yuhua Rd, Chenggong 
      City, Kunming, Yunnan 650500, China.
FAU - Liu, Lijun
AU  - Liu L
AD  - College of Chinese Materia Medica and Yunnan Key Laboratory of Southern Medicinal 
      Utilization, Yunnan University of Chinese Medicine, 1076 Yuhua Rd, Chenggong 
      City, Kunming, Yunnan 650500, China.
FAU - Du, Yao
AU  - Du Y
AD  - College of Chinese Materia Medica and Yunnan Key Laboratory of Southern Medicinal 
      Utilization, Yunnan University of Chinese Medicine, 1076 Yuhua Rd, Chenggong 
      City, Kunming, Yunnan 650500, China.
FAU - Fan, Ruoxi
AU  - Fan R
AD  - College of Chinese Materia Medica and Yunnan Key Laboratory of Southern Medicinal 
      Utilization, Yunnan University of Chinese Medicine, 1076 Yuhua Rd, Chenggong 
      City, Kunming, Yunnan 650500, China.
FAU - Zhang, Rongping
AU  - Zhang R
AD  - College of Chinese Materia Medica and Yunnan Key Laboratory of Southern Medicinal 
      Utilization, Yunnan University of Chinese Medicine, 1076 Yuhua Rd, Chenggong 
      City, Kunming, Yunnan 650500, China.
FAU - Zhou, Ningna
AU  - Zhou N
AD  - College of Chinese Materia Medica and Yunnan Key Laboratory of Southern Medicinal 
      Utilization, Yunnan University of Chinese Medicine, 1076 Yuhua Rd, Chenggong 
      City, Kunming, Yunnan 650500, China. Electronic address: zhningna@ynutcm.edu.cn.
LA  - eng
PT  - Journal Article
DEP - 20220803
PL  - Germany
TA  - Phytomedicine
JT  - Phytomedicine : international journal of phytotherapy and phytopharmacology
JID - 9438794
RN  - 0 (Benzaldehydes)
SB  - IM
MH  - Animals
MH  - Astrocytes
MH  - Benzaldehydes
MH  - *Brain Ischemia
MH  - Cerebral Cortex
MH  - Cicatrix
MH  - *Gliosis
MH  - Infarction, Middle Cerebral Artery
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Reperfusion
MH  - Wnt Signaling Pathway
OTO - NOTNLM
OT  - Glial scar
OT  - Ischemic stroke
OT  - Neurogenesis
OT  - p-hydroxy benzaldehyde
EDAT- 2022/08/21 06:00
MHDA- 2022/08/31 06:00
CRDT- 2022/08/20 18:19
PHST- 2022/05/27 00:00 [received]
PHST- 2022/07/21 00:00 [revised]
PHST- 2022/08/02 00:00 [accepted]
PHST- 2022/08/21 06:00 [pubmed]
PHST- 2022/08/31 06:00 [medline]
PHST- 2022/08/20 18:19 [entrez]
AID - S0944-7113(22)00458-5 [pii]
AID - 10.1016/j.phymed.2022.154379 [doi]
PST - ppublish
SO  - Phytomedicine. 2022 Oct;105:154379. doi: 10.1016/j.phymed.2022.154379. Epub 2022 
      Aug 3.