PMID- 35988424
OWN - NLM
STAT- MEDLINE
DCOM- 20220915
LR  - 20220915
IS  - 1950-6007 (Electronic)
IS  - 0753-3322 (Linking)
VI  - 154
DP  - 2022 Oct
TI  - Achyranthes bidentata polysaccharides alleviate endoplasmic reticulum stress in 
      osteoarthritis via lncRNA NEAT1/miR-377-3p pathway.
PG  - 113551
LID - S0753-3322(22)00940-4 [pii]
LID - 10.1016/j.biopha.2022.113551 [doi]
AB  - Endoplasmic reticulum stress (ERS) has been identified to be an important factor 
      leading to chondrocyte apoptosis in osteoarthritis (OA). Previous studies have 
      confirmed that Achyranthes bidentata polysaccharides (ABPS) can inhibit 
      chondrocyte apoptosis; however, the mechanism of action of ABPS on chondrocyte 
      ERS remains unclear. Thus in this study, we aim to investigate whether ABPS could 
      inhibit OA-associated chondrocyte apoptosis by regulating ERS, especially by 
      observing the relationship between the lncRNA NEAT1 and miR-377-3p, to explore 
      further the protective mechanism of ABPS in OA. In vitro and in vivo experiments 
      showed that ABPS inhibited chondrocyte ERS by regulating the expression of lncRNA 
      NEAT1 and miR-377-3p. Moreover, both lncRNA NEAT1 silencing and miR-377-3p 
      inhibition could attenuate the therapeutic effect of ABPS on ERS. Dual-luciferase 
      results indicated that miR-377-3p targets the lncRNA NEAT1 gene in mouse 
      chondrocytes. Therefore, we concluded that ABPS could inhibit thapsigargin 
      (TG)-induced chondrocyte ERS through the lncRNA NEAT1/miR-377-3p axis.
CI  - Copyright (c) 2022 The Authors. Published by Elsevier Masson SAS.. All rights 
      reserved.
FAU - Fu, Changlong
AU  - Fu C
AD  - Academy of Integrative Medicine, Fujian University of Traditional Chinese 
      Medicine, 1 Qiuyang Road, Fuzhou, Fujian 350122, China; Fujian Provincial Key 
      Laboratory of Integrative Medicine on Geriatrics, Fuzhou, Fujian 350122, China.
FAU - Qiu, Zhiwei
AU  - Qiu Z
AD  - Academy of Integrative Medicine, Fujian University of Traditional Chinese 
      Medicine, 1 Qiuyang Road, Fuzhou, Fujian 350122, China; Fujian Provincial Key 
      Laboratory of Integrative Medicine on Geriatrics, Fuzhou, Fujian 350122, China.
FAU - Huang, Yanfeng
AU  - Huang Y
AD  - Academy of Integrative Medicine, Fujian University of Traditional Chinese 
      Medicine, 1 Qiuyang Road, Fuzhou, Fujian 350122, China; Fujian Provincial Key 
      Laboratory of Integrative Medicine on Geriatrics, Fuzhou, Fujian 350122, China.
FAU - Lin, Qing
AU  - Lin Q
AD  - Academy of Integrative Medicine, Fujian University of Traditional Chinese 
      Medicine, 1 Qiuyang Road, Fuzhou, Fujian 350122, China; Fujian Provincial Key 
      Laboratory of Integrative Medicine on Geriatrics, Fuzhou, Fujian 350122, China.
FAU - Jin, Linglu
AU  - Jin L
AD  - Academy of Integrative Medicine, Fujian University of Traditional Chinese 
      Medicine, 1 Qiuyang Road, Fuzhou, Fujian 350122, China; Fujian Provincial Key 
      Laboratory of Integrative Medicine on Geriatrics, Fuzhou, Fujian 350122, China.
FAU - Tu, Haishui
AU  - Tu H
AD  - Academy of Integrative Medicine, Fujian University of Traditional Chinese 
      Medicine, 1 Qiuyang Road, Fuzhou, Fujian 350122, China; Fujian Provincial Key 
      Laboratory of Integrative Medicine on Geriatrics, Fuzhou, Fujian 350122, China.
FAU - Ye, Jinxia
AU  - Ye J
AD  - Academy of Integrative Medicine, Fujian University of Traditional Chinese 
      Medicine, 1 Qiuyang Road, Fuzhou, Fujian 350122, China; Fujian Provincial Key 
      Laboratory of Integrative Medicine on Geriatrics, Fuzhou, Fujian 350122, China.
FAU - Zheng, Chunsong
AU  - Zheng C
AD  - Academy of Integrative Medicine, Fujian University of Traditional Chinese 
      Medicine, 1 Qiuyang Road, Fuzhou, Fujian 350122, China; Fujian Provincial Key 
      Laboratory of Integrative Medicine on Geriatrics, Fuzhou, Fujian 350122, China.
FAU - Zhong, Weihong
AU  - Zhong W
AD  - Rehabilitation Hospital Affiliated to Fujian University of Traditional Chinese 
      Medicine, Fuzhou, Fujian 350003, China; Fujian Key Laboratory of Rehabilitation 
      Technology, Fuzhou, Fujian 350003, China. Electronic address: 
      zhongweihong@fjtcm.edu.cn.
FAU - Ma, Dezun
AU  - Ma D
AD  - Academy of Integrative Medicine, Fujian University of Traditional Chinese 
      Medicine, 1 Qiuyang Road, Fuzhou, Fujian 350122, China; Fujian Provincial Key 
      Laboratory of Integrative Medicine on Geriatrics, Fuzhou, Fujian 350122, China. 
      Electronic address: 2021025@fjtcm.edu.cn.
LA  - eng
PT  - Journal Article
DEP - 20220819
PL  - France
TA  - Biomed Pharmacother
JT  - Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie
JID - 8213295
RN  - 0 (MicroRNAs)
RN  - 0 (Polysaccharides)
RN  - 0 (RNA, Long Noncoding)
SB  - IM
MH  - *Achyranthes
MH  - Animals
MH  - Apoptosis
MH  - Chondrocytes/metabolism
MH  - Endoplasmic Reticulum Stress
MH  - Mice
MH  - *MicroRNAs/metabolism
MH  - *Osteoarthritis/drug therapy/genetics/metabolism
MH  - Polysaccharides/metabolism/pharmacology
MH  - *RNA, Long Noncoding/metabolism
OTO - NOTNLM
OT  - Achyranthes bidentata polysaccharides
OT  - Endoplasmic reticulum stress
OT  - LncRNA NEAT1
OT  - Osteoarthritis
OT  - miR-377-3p
COIS- Conflict of interest There are no conflicts of interest to declare.
EDAT- 2022/08/22 06:00
MHDA- 2022/09/16 06:00
CRDT- 2022/08/21 18:23
PHST- 2022/06/18 00:00 [received]
PHST- 2022/08/03 00:00 [revised]
PHST- 2022/08/14 00:00 [accepted]
PHST- 2022/08/22 06:00 [pubmed]
PHST- 2022/09/16 06:00 [medline]
PHST- 2022/08/21 18:23 [entrez]
AID - S0753-3322(22)00940-4 [pii]
AID - 10.1016/j.biopha.2022.113551 [doi]
PST - ppublish
SO  - Biomed Pharmacother. 2022 Oct;154:113551. doi: 10.1016/j.biopha.2022.113551. Epub 
      2022 Aug 19.