PMID- 35988632
OWN - NLM
STAT- MEDLINE
DCOM- 20221019
LR  - 20221019
IS  - 1879-1026 (Electronic)
IS  - 0048-9697 (Linking)
VI  - 851
IP  - Pt 1
DP  - 2022 Dec 10
TI  - Lung function decline associated with individual short-term exposure to PM(1), 
      PM(2.5) and PM(10) in patients with allergic rhinoconjunctivitis.
PG  - 158151
LID - S0048-9697(22)05250-0 [pii]
LID - 10.1016/j.scitotenv.2022.158151 [doi]
AB  - BACKGROUND: The susceptibility of allergic rhinoconjunctivitis (ARC) patients to 
      air pollution has yet to be clarified. OBJECTIVES: Based on a repeated 
      measurement panel study, we explored the association of short-term PM exposure 
      with lung function in ARC patients and to further identify the susceptible 
      populations. METHODS: Personal PM exposure, including PM(1), PM(2.5) and PM(10), 
      was monitored consecutively for three days before outcomes measurements. Lung 
      function indices including forced vital capacity (FVC), forced expiratory volume 
      in 1 s (FEV(1)), peak expiratory flow (PEF), and forced expiratory flow at 25-75 
      % of the vital capacity (FEF(25)(-)(75)) were measured. Serum total 
      immunoglobulin E (IgE), specific-allergen IgE, blood eosinophil and basophils, 
      and the symptoms severe scores were tested in each visit. Linear mixed effect 
      models were applied to estimate the association between PM exposure and lung 
      function. Furthermore, stratified and overlapping grouped populations based on 
      IgE levels were implemented to characterize the modification role and the 
      modulating threshold of IgE at which the association turned significantly 
      negative. RESULTS: Short-term PM personal exposure was associated with a 
      significant decrease in lung function in ARC patients, especially for small 
      airway respiratory indexes. The highest estimates occurred in PM(1), specifically 
      a 10 mug/m(3) increase reduced FEV(1)/FVC, PEF and FEF(25)(-)(75) by 1.36 % (95 
      %CI: -2.29 to -0.43), 0.23 L/s (95 %CI: -0.42 to -0.03) and 0.18 L/s (95 %CI: 
      -0.30 to -0.06), respectively. Notably, PM-induced decreases in lung function 
      were stronger in patients with higher IgE levels (IgE >/= 100 IU/mL), which were 
      related to higher inflammatory cytokines and symptoms scores. Further, 
      PM-associated lung function declines enhanced robustly and monotonically with 
      increasing IgE concentration. Potential modulating thresholds of IgE occurred at 
      46.8-59.6 IU/mL for significant PM-lung function associations. CONCLUSION: These 
      novel findings estimated the short-term effects of PM on lung function in ARC 
      patients, and the threshold values of IgE for the significant and robust 
      associations.
CI  - Copyright (c) 2022 Elsevier B.V. All rights reserved.
FAU - Li, Sai
AU  - Li S
AD  - School of Energy and Environmental Engineering, University of Science and 
      Technology Beijing, Beijing 100083, China.
FAU - Wang, Gang
AU  - Wang G
AD  - Department of Otolaryngology-Head and Neck Surgery, PLA Strategic Support Force 
      Characteristic Medical Center, Beijing 100101, China.
FAU - Geng, Yishuo
AU  - Geng Y
AD  - School of Energy and Environmental Engineering, University of Science and 
      Technology Beijing, Beijing 100083, China.
FAU - Wu, Wei
AU  - Wu W
AD  - Department of Otolaryngology-Head and Neck Surgery, PLA Strategic Support Force 
      Characteristic Medical Center, Beijing 100101, China.
FAU - Duan, Xiaoli
AU  - Duan X
AD  - School of Energy and Environmental Engineering, University of Science and 
      Technology Beijing, Beijing 100083, China. Electronic address: 
      jasmine@ustb.edu.cn.
LA  - eng
PT  - Journal Article
DEP - 20220818
PL  - Netherlands
TA  - Sci Total Environ
JT  - The Science of the total environment
JID - 0330500
RN  - 0 (Air Pollutants)
RN  - 0 (Allergens)
RN  - 0 (Cytokines)
RN  - 0 (Particulate Matter)
RN  - 37341-29-0 (Immunoglobulin E)
SB  - IM
MH  - *Air Pollutants/analysis
MH  - *Air Pollution
MH  - Allergens
MH  - Cytokines
MH  - Environmental Exposure
MH  - Forced Expiratory Volume
MH  - Humans
MH  - Immunoglobulin E
MH  - Lung
MH  - Particulate Matter/analysis
OTO - NOTNLM
OT  - Allergic rhinoconjunctivitis
OT  - Immunoglobulin E
OT  - Lung function
OT  - Particulate matter
COIS- Declaration of competing interest The authors declare that they have no known 
      competing financial interests or personal relationships that could have appeared 
      to influence the work reported in this paper.
EDAT- 2022/08/22 06:00
MHDA- 2022/10/20 06:00
CRDT- 2022/08/21 19:23
PHST- 2022/06/04 00:00 [received]
PHST- 2022/08/14 00:00 [revised]
PHST- 2022/08/16 00:00 [accepted]
PHST- 2022/08/22 06:00 [pubmed]
PHST- 2022/10/20 06:00 [medline]
PHST- 2022/08/21 19:23 [entrez]
AID - S0048-9697(22)05250-0 [pii]
AID - 10.1016/j.scitotenv.2022.158151 [doi]
PST - ppublish
SO  - Sci Total Environ. 2022 Dec 10;851(Pt 1):158151. doi: 
      10.1016/j.scitotenv.2022.158151. Epub 2022 Aug 18.