PMID- 35989475
OWN - NLM
STAT- MEDLINE
DCOM- 20230307
LR  - 20230307
IS  - 1439-0396 (Electronic)
IS  - 0931-2439 (Linking)
VI  - 107
IP  - 2
DP  - 2023 Mar
TI  - Antioxidant monoammonium glycyrrhizinate alleviates damage from oxidative stress 
      in perinatal cows.
PG  - 475-484
LID - 10.1111/jpn.13764 [doi]
AB  - This study was conducted to evaluate the antioxidant capability of dietary 
      supplementation with monoammonium glycyrrhizinate (MAG) in perinatal cows. 
      Glycyrrhizic acid has been shown to have strong antioxidant activity and we 
      hypothesised that the aglycone of glycyrrhizin and MAG, could reduce damage from 
      oxidative stress in perinatal cows by enhancing antioxidant capacity. Blood and 
      milk samples were collected from three groups of healthy perinatal cows that were 
      similar in body weight, parity, milk yield in the last milk cycle, etc., 
      receiving dietary MAG supplementation ([Day 0 = parturition]: 0 g/day, [n = 13)] 
      3 g/day [n = 13] or 6 g/day [n = 11]) from -28 to 56 day (0 day = parturition). 
      Compared with 0 g/day controls (CON), milk fat was significantly decreased in 
      cows fed with MAG, and 3 g/day had the greatest effect. A diet containing 3 g/day 
      MAG decreased the serum alanine aminotransferase (ALT) level compared with CON at 
      -7 day post-partum. ALT was also lower at 5 day post-partum in cows fed with 
      3 g/day MAG compared to 6 g/day. The administration of 3 g/day and 6 g/day MAG 
      decreased serum aspartate transaminase (AST) at 3 day post-partum. 
      Supplementation of MAG in cows increased total antioxidant capacity (T-AOC) in 
      serum, and cows given 3 g MAG per day had higher T-AOC than controls on 
      post-partum 7 day. At the end of the experiment, we isolated and cultured primary 
      hepatocytes to determine the effect of MAG on oxidative stress caused by 
      incubation with the sodium oleate (SO). SO increased lipid synthesis, but 
      pre-treatment with MAG prevented the fatty buildup. SO treatment increased AST 
      and ALT levels and malondialdehyde concentration, but decreased T-AOC and 
      superoxide dismutase (SOD). Incubation with MAG increased antioxidant capacity 
      and inhibited oxidant damage in bovine hepatocytes. SO stimulated expression of 
      the antioxidant genes, NAD(P)H quinone dehydrogenase 1 (NQO1) and SOD1, in the 
      nuclear factor erythroid 2-related factor 2 (NRF2) pathway, and catalase 1 
      (CAT1); this increase was accentuated by MAG pre-treatment. The results suggest 
      that MAG can alleviate the damage caused by oxidative stress in perinatal cows by 
      enhancing antioxidant activity.
CI  - (c) 2022 Wiley-VCH GmbH.
FAU - Zhang, Cai
AU  - Zhang C
AUID- ORCID: 0000-0002-0918-6601
AD  - Henan International Joint Laboratory of Animal Welfare and Health Breeding, Henan 
      University of Science and Technology, Luoyang, China.
FAU - Li, Chenxu
AU  - Li C
AUID- ORCID: 0000-0003-0053-0768
AD  - Henan International Joint Laboratory of Animal Welfare and Health Breeding, Henan 
      University of Science and Technology, Luoyang, China.
FAU - Shao, Qi
AU  - Shao Q
AD  - Henan International Joint Laboratory of Animal Welfare and Health Breeding, Henan 
      University of Science and Technology, Luoyang, China.
FAU - Meng, Sudan
AU  - Meng S
AD  - Henan International Joint Laboratory of Animal Welfare and Health Breeding, Henan 
      University of Science and Technology, Luoyang, China.
FAU - Wang, Xueying
AU  - Wang X
AD  - Henan International Joint Laboratory of Animal Welfare and Health Breeding, Henan 
      University of Science and Technology, Luoyang, China.
FAU - Kong, Tao
AU  - Kong T
AD  - Henan International Joint Laboratory of Animal Welfare and Health Breeding, Henan 
      University of Science and Technology, Luoyang, China.
FAU - Li, Yu
AU  - Li Y
AUID- ORCID: 0000-0002-9886-4952
AD  - College of Animal Science and Technology, Anhui Agricultural University, Heifei, 
      China.
LA  - eng
GR  - 183400410012/Science Popularisation Foundation of Henan Province/
GR  - 31872537/National Natural Science Foundation of China/
GR  - 182300410087/Natural Science Foundation of Henan Province/
PT  - Journal Article
DEP - 20220821
PL  - Germany
TA  - J Anim Physiol Anim Nutr (Berl)
JT  - Journal of animal physiology and animal nutrition
JID - 101126979
RN  - 0 (Antioxidants)
RN  - 6FO62043WK (Glycyrrhizic Acid)
RN  - P540XA09DR (Glycyrrhetinic Acid)
SB  - IM
MH  - Pregnancy
MH  - Female
MH  - Cattle
MH  - Animals
MH  - *Antioxidants/metabolism
MH  - Glycyrrhizic Acid/metabolism/pharmacology
MH  - Oxidative Stress
MH  - Parturition
MH  - Diet/veterinary
MH  - Milk/metabolism
MH  - *Glycyrrhetinic Acid/metabolism/pharmacology
MH  - Dietary Supplements
MH  - Lactation
OTO - NOTNLM
OT  - monoammonium glycyrrhizinate
OT  - oxidative stress
OT  - perinatal cows
OT  - sodium oleate
EDAT- 2022/08/23 06:00
MHDA- 2023/03/08 06:00
CRDT- 2022/08/22 01:12
PHST- 2022/04/17 00:00 [revised]
PHST- 2021/09/01 00:00 [received]
PHST- 2022/08/03 00:00 [accepted]
PHST- 2022/08/23 06:00 [pubmed]
PHST- 2023/03/08 06:00 [medline]
PHST- 2022/08/22 01:12 [entrez]
AID - 10.1111/jpn.13764 [doi]
PST - ppublish
SO  - J Anim Physiol Anim Nutr (Berl). 2023 Mar;107(2):475-484. doi: 10.1111/jpn.13764. 
      Epub 2022 Aug 21.