PMID- 35990032
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220823
IS  - 2146-4596 (Print)
IS  - 2146-460X (Electronic)
IS  - 2146-460X (Linking)
VI  - 11
IP  - 3
DP  - 2022 Sep
TI  - Determination of High-Resolution HLA-DQB1 Suballeles and IL-17 Polymorphisms in 
      Turkish Pediatric Patients.
PG  - 192-197
LID - 10.1055/s-0041-1722856 [doi]
AB  - Celiac disease (CD) is an autoimmune enteropathy in the small intestine caused by 
      gluten intolerance of the patients. The most important genetic disease-related 
      factor is human leukocyte antigen (HLA)-DQ polymorphism. Association between 
      interleukin (IL)-17A expression of CD4 (+) T cells and various autoimmune 
      diseases has been reported. The aim of this study was to investigate the 
      relationship between single nucleotide polymorphism (rs2275913) IL-17A and HLA-DQ 
      polymorphisms in Turkish pediatric celiac patients. Study group included 125 
      pediatric celiac patients with CD and 100 healthy pediatric controls. 
      Deoxyribonucleic acid was isolated from peripheral blood samples. IL-17A 
      polymorphism (rs2275913) was analyzed by polymerase chain reaction-restriction 
      fragment polymorphism method. IL-17A polymorphism and low-/high-resolution HLA-DQ 
      results of patients were evaluated. GG and GA genotype frequencies of IL-17A 
      (rs2275913) polymorphism were significantly higher ( p  < 0.05) in the CD 
      patients than the control group. HLA-DQB1*02 and HLA-DQA1*05 alleles were 
      detected in patients, while HLA-DQB1*03 and HLA-DQA1*01 alleles in the control 
      group. Also, when we compared the patient and control groups in terms of 
      HLA-DQ-DR haplotypes, HLA-DQB1*02-DQA1*05-DRB1*03 was found with the relative 
      risk of 42.5 ( p  < 0.05). As a result of high-resolution HLA-DQB1 typing, 
      DQB1*02:01 and DQB1*03:02 were at high frequency ( p  < 0.05; in 25 patient 
      group). IL-17A (rs2275913) polymorphism genotype frequency was found to be 
      significant in the patient group compared with the control group. The most common 
      HLA-DQB1 suballele was observed as DQB1*02:01.
CI  - Thieme. All rights reserved.
FAU - Eldem, Asli
AU  - Eldem A
AUID- ORCID: 0000-0003-3510-6748
AD  - Department of Medical Biology and Genetics, Izmir Katip Celebi University, Izmir 
      Tepecik Education and Research Hospital Tissue Typing Laboratory, Izmir, Turkey.
FAU - Ayna, Tulay Kilicaslan
AU  - Ayna TK
AUID- ORCID: 0000-0001-7993-978X
AD  - Department of Medical Biology and Genetics, Izmir Katip Celebi University, Izmir 
      Tepecik Education and Research Hospital Tissue Typing Laboratory, Izmir, Turkey.
FAU - Baran, Masallah
AU  - Baran M
AUID- ORCID: 0000-0003-3827-2039
AD  - Department of Pediatric Gastroenterology, Izmir Katip Celebi University, Izmir 
      Tepecik Education and Research Hospital, Izmir, Turkey.
FAU - Soyoz, Mustafa
AU  - Soyoz M
AUID- ORCID: 0000-0001-5159-6463
AD  - Department of Medical Biology and Genetics, Izmir Katip Celebi University, Izmir 
      Tepecik Education and Research Hospital Tissue Typing Laboratory, Izmir, Turkey.
FAU - Pirim, Ibrahim
AU  - Pirim I
AUID- ORCID: 0000-0001-8485-3286
AD  - Department of Medical Biology and Genetics, Izmir Katip Celebi University, Izmir 
      Tepecik Education and Research Hospital Tissue Typing Laboratory, Izmir, Turkey.
LA  - eng
PT  - Journal Article
DEP - 20210211
PL  - Germany
TA  - J Pediatr Genet
JT  - Journal of pediatric genetics
JID - 101589859
PMC - PMC9385257
OTO - NOTNLM
OT  - IL-17 polymorphism
OT  - celiac disease
OT  - gluten
OT  - human leukocyte antigen-DQ polymorphism
OT  - pediatric
COIS- Conflict of Interest None declared.
EDAT- 2021/02/11 00:00
MHDA- 2021/02/11 00:01
PMCR- 2022/02/11
CRDT- 2022/08/22 03:49
PHST- 2020/08/25 00:00 [received]
PHST- 2020/12/12 00:00 [accepted]
PHST- 2022/08/22 03:49 [entrez]
PHST- 2021/02/11 00:00 [pubmed]
PHST- 2021/02/11 00:01 [medline]
PHST- 2022/02/11 00:00 [pmc-release]
AID - 2000142 [pii]
AID - 10.1055/s-0041-1722856 [doi]
PST - epublish
SO  - J Pediatr Genet. 2021 Feb 11;11(3):192-197. doi: 10.1055/s-0041-1722856. 
      eCollection 2022 Sep.