PMID- 35990304
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220823
IS  - 1302-7123 (Print)
IS  - 1308-5123 (Electronic)
IS  - 1302-7123 (Linking)
VI  - 56
IP  - 2
DP  - 2022
TI  - Intrathyroidal Parathyroid Adenomas in Primary Hyperparathyroidism: Clinical and 
      Imaging Findings.
PG  - 256-261
LID - 10.14744/SEMB.2022.82584 [doi]
AB  - OBJECTIVES: Primary hyperparathyroidism (PHPT) is a common endocrine disease. 
      Ectopic adenomas may cause a failed surgery which results in persistence or 
      recurrence. Intrathyroidal parathyroid adenoma (ITPA) is a rare reason for PHPT 
      and site of ectopia. Herein, we aimed to investigate the clinical and imaging 
      features of patients with ITPAs and the effectiveness of radiological tools for 
      localization at a tertiary reference center. METHODS: The files of 708 
      consecutive patients who underwent parathyroidectomy for PHPT in our department 
      between January 2007 and December 2021 were investigated retrospectively. PHPT 
      patients with ITPA were included in the study. Patients with missing data were 
      excluded from the study. Clinicopathological features of the patients and 
      radiological evaluation findings were investigated. RESULTS: Twenty-eight 
      (28/708: 3.9%) patients were included in the study. The complete intrathyroidal 
      gland and subcapsular parathyroid gland were observed in 8 (1.1%) and 20 (2.8%) 
      patients, respectively. The ultrasound and parathyroid scintigraphy revealed the 
      accurate localization of ITPA in 25 (89.3%) and 18 (64.3%) patients, 
      respectively. Additional imaging modalities were applied for 10 patients in which 
      conventional localization studies were discordant or inconclusive. ITPAs were 
      most commonly found in the lower gland (n=20) localization. All patients had a 
      successful parathyroidectomy and neither persistence nor recurrence was occurred 
      in the study group. CONCLUSION: The ITPAs are rare in PHPT. The ultrasound has a 
      high diagnostic rate in experienced hands. The second-line imaging methods may be 
      favorable in the presence of negative or discordant scans. The pre-operative 
      localization studies can detect the ITPAs in most patients, so blind 
      thyroidectomy should be avoided.
CI  - (c) Copyright 2022 by The Medical Bulletin of Sisli Etfal Hospital.
FAU - Haciyanli, Selda Gucek
AU  - Haciyanli SG
AD  - Department of General Surgery, Izmir Katip Celebi University Ataturk Training and 
      Research Hospital, Izmir, Turkey.
FAU - Karaisli, Serkan
AU  - Karaisli S
AD  - Department of General Surgery, Izmir Katip Celebi University Ataturk Training and 
      Research Hospital, Izmir, Turkey.
FAU - Erdogan, Nezahat
AU  - Erdogan N
AD  - Department of Radiology, Izmir Katip Celebi University Ataturk Training and 
      Research Hospital, Izmir, Turkey.
FAU - Turgut, Bulent
AU  - Turgut B
AD  - Department of Nuclear Medicine, Izmir Katip Celebi University Ataturk Training 
      and Research Hospital, Izmir, Turkey.
FAU - Gur, Emine Ozlem
AU  - Gur EO
AD  - Department of General Surgery, Izmir Katip Celebi University Ataturk Training and 
      Research Hospital, Izmir, Turkey.
FAU - Haciyanli, Mehmet
AU  - Haciyanli M
AD  - Department of General Surgery, Izmir Katip Celebi University Ataturk Training and 
      Research Hospital, Izmir, Turkey.
LA  - eng
PT  - Journal Article
DEP - 20220628
PL  - Turkey
TA  - Sisli Etfal Hastan Tip Bul
JT  - Sisli Etfal Hastanesi tip bulteni
JID - 9424130
PMC - PMC9350060
OTO - NOTNLM
OT  - Adenoma
OT  - hyperparathyroidism
OT  - intrathyroidal
OT  - parathyroidectomy
OT  - thyroid
COIS- None declared.
EDAT- 2022/08/23 06:00
MHDA- 2022/08/23 06:01
PMCR- 2022/06/28
CRDT- 2022/08/22 03:53
PHST- 2022/03/24 00:00 [received]
PHST- 2022/04/07 00:00 [accepted]
PHST- 2022/08/22 03:53 [entrez]
PHST- 2022/08/23 06:00 [pubmed]
PHST- 2022/08/23 06:01 [medline]
PHST- 2022/06/28 00:00 [pmc-release]
AID - SEMB-56-256 [pii]
AID - 10.14744/SEMB.2022.82584 [doi]
PST - epublish
SO  - Sisli Etfal Hastan Tip Bul. 2022 Jun 28;56(2):256-261. doi: 
      10.14744/SEMB.2022.82584. eCollection 2022.