PMID- 35990493
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220823
IS  - 2470-1343 (Electronic)
IS  - 2470-1343 (Linking)
VI  - 7
IP  - 32
DP  - 2022 Aug 16
TI  - Biodegradable Magnetic Molecularly Imprinted Anticancer Drug Carrier for the 
      Targeted Delivery of Docetaxel.
PG  - 28516-28524
LID - 10.1021/acsomega.2c03299 [doi]
AB  - Molecularly imprinted biodegradable polymers are receiving considerable attention 
      in drug delivery due to their ability of targeted recognition and 
      biocompatibility. This study reports the synthesis of a novel fluorescence-active 
      magnetic molecularly imprinted drug carrier (MIDC) using a glucose-based 
      biodegradable cross-linking agent for the delivery of anticancer drug docetaxel. 
      The magnetic molecularly imprinted polymer (MMIP) was characterized through 
      scanning electron microscopy (SEM), Fourier transform infrared spectroscopy 
      (FTIR), X-ray diffraction spectroscopy, and vibrating sample magnetometry (VSM). 
      The MMIP presented a magnetization value of 0.0059 emu g(-1) and binding capacity 
      of 72 mg g(-1) with docetaxel. In vitro and in vivo studies were performed to 
      observe the effectiveness of the MIDC for drug delivery. The cell viability assay 
      suggested that the MMIP did not present toxic effects on healthy cells. The 
      magnetic property of the MMIP allowed quick identification of the drug carrier at 
      the target site by applying the external magnetic field to mice (after 20 min of 
      loading) and taking X-ray images. The novel MMIP-based drug carrier could thus 
      deliver the drug at the target site without affecting the healthy cells.
CI  - (c) 2022 The Authors. Published by American Chemical Society.
FAU - Ali, Zeeshan
AU  - Ali Z
AD  - Institute of Chemical Sciences, Bahauddin Zakariya University, Multan 60000, 
      Pakistan.
FAU - Sajid, Muhammad
AU  - Sajid M
AD  - Institute of Chemical Sciences, Bahauddin Zakariya University, Multan 60000, 
      Pakistan.
FAU - Manzoor, Suryyia
AU  - Manzoor S
AD  - Institute of Chemical Sciences, Bahauddin Zakariya University, Multan 60000, 
      Pakistan.
FAU - Ahmad, Muhammad Mahboob
AU  - Ahmad MM
AD  - Institute of Chemical Sciences, Bahauddin Zakariya University, Multan 60000, 
      Pakistan.
FAU - Khan, Muhammad Imran
AU  - Khan MI
AD  - Research Institute of Sciences and Engineering (RISE), University of Sharjah, 
      Sharjah 27272, United Arab Emirates.
FAU - Elboughdiri, Noureddine
AU  - Elboughdiri N
AUID- ORCID: 0000-0003-2923-3062
AD  - Chemical Engineering Process Department, National School of Engineers Gabes, 
      University of Gabes, Gabes 6011, Tunisia.
FAU - Kashif, Muhammad
AU  - Kashif M
AD  - Department of Chemistry, Emerson University, Multan 60000, Pakistan.
FAU - Shanableh, Abdallah
AU  - Shanableh A
AD  - Research Institute of Sciences and Engineering (RISE), University of Sharjah, 
      Sharjah 27272, United Arab Emirates.
FAU - Rajhi, Wajdi
AU  - Rajhi W
AD  - Mechanical Engineering Department, College of Engineering, University of Ha'il, 
      P.O. Box 2440, Ha'il 81441,Saudi Arabia.
FAU - Mersni, Wael
AU  - Mersni W
AD  - National School of Engineers of Tunis, University of Tunis El Manar, Tunis 1068, 
      Tunisia.
FAU - Bayraktar, Emin
AU  - Bayraktar E
AD  - School of Mechanical and Manufacturing Engineering, ISAE-SUPMECA Institute of 
      Mechanics of Paris, Saint-Ouen 93400, France.
FAU - Salem, Sahbi Ben
AU  - Salem SB
AD  - National School of Engineers of Tunis, University of Tunis El Manar, Tunis 1068, 
      Tunisia.
LA  - eng
PT  - Journal Article
DEP - 20220802
PL  - United States
TA  - ACS Omega
JT  - ACS omega
JID - 101691658
PMC - PMC9386705
COIS- The authors declare no competing financial interest.
EDAT- 2022/08/23 06:00
MHDA- 2022/08/23 06:01
PMCR- 2022/08/02
CRDT- 2022/08/22 03:55
PHST- 2022/05/27 00:00 [received]
PHST- 2022/07/22 00:00 [accepted]
PHST- 2022/08/22 03:55 [entrez]
PHST- 2022/08/23 06:00 [pubmed]
PHST- 2022/08/23 06:01 [medline]
PHST- 2022/08/02 00:00 [pmc-release]
AID - 10.1021/acsomega.2c03299 [doi]
PST - epublish
SO  - ACS Omega. 2022 Aug 2;7(32):28516-28524. doi: 10.1021/acsomega.2c03299. 
      eCollection 2022 Aug 16.