PMID- 35992081
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220823
IS  - 2589-0042 (Electronic)
IS  - 2589-0042 (Linking)
VI  - 25
IP  - 8
DP  - 2022 Aug 19
TI  - The role of tetraspanins pan-cancer.
PG  - 104777
LID - 10.1016/j.isci.2022.104777 [doi]
LID - 104777
AB  - Tetraspanins (TSPANs) are a class of four-transmembrane segmented proteins. The 
      precise functions of TSPANs and their roles in pan-cancer are unclear. In this 
      work, we analyzed TSPAN1, TSPAN10, TSPAN11, TSPAN12, TSPAN13, TSPAN14, TSPAN15, 
      TSPAN16, TSPAN17, TSPAN18, TSPAN18-AS1, TSPAN19, TSPAN2, TSPAN3, TSPAN31, 
      TSPAN32, TSPAN33, TSPAN4, TSPAN5, TSPAN6, TSPAN7, TSPAN8, TSPAN9, TSPAN9-IT1 (24 
      TSPAN family genes) in relation to tumor characteristics from 11,057 TCGA samples 
      across 33 cancer types. On 24 TSPAN family genes, multidimensional studies were 
      conducted, including gene differential expression, immunological subtype 
      analysis, clinical analysis, stemness indices analysis, drug sensitivity 
      analysis, alteration analysis, and multi-omics validation (including ATAC-seq 
      validation, single-cell sequencing validation, and other external validation). 
      Genes were differentially expressed in 33 cancers, and several of them showed 
      high consistency in terms of tumor characteristics. In particular, the potential 
      roles of TSPAN15 and TSPAN1 in cancer deserve further attention.
CI  - (c) 2022 The Author(s).
FAU - Huang, Runzhi
AU  - Huang R
AD  - Department of Orthopedics, The First Affiliated Hospital of Zhengzhou University, 
      1 East Jianshe Road, Zhengzhou, 450052, China.
AD  - Division of Spine Surgery, Department of Orthopaedics, Tongji Hospital, Tongji 
      University School of Medicine, Shanghai, 200065, China.
AD  - Key Laboratory of Spine and Spinal Cord Injury Repair and Regeneration (Tongji 
      University), Ministry of Education, Shanghai, 200065, China.
AD  - Tongji University School of Medicine, 1239 Siping Road, Shanghai, 200092, China.
FAU - Sun, Hanlin
AU  - Sun H
AD  - Department of Orthopedics, The First Affiliated Hospital of Zhengzhou University, 
      1 East Jianshe Road, Zhengzhou, 450052, China.
AD  - Department of Thyroid Surgery, The First Affiliated Hospital of Zhengzhou 
      University, 1 East Jianshe Road, Zhengzhou, 450052, China.
FAU - Lin, Ruoyi
AU  - Lin R
AD  - Tongji University School of Medicine, 1239 Siping Road, Shanghai, 200092, China.
FAU - Zhang, Jie
AU  - Zhang J
AD  - Division of Spine Surgery, Department of Orthopaedics, Tongji Hospital, Tongji 
      University School of Medicine, Shanghai, 200065, China.
AD  - Key Laboratory of Spine and Spinal Cord Injury Repair and Regeneration (Tongji 
      University), Ministry of Education, Shanghai, 200065, China.
AD  - Tongji University School of Medicine, 1239 Siping Road, Shanghai, 200092, China.
FAU - Yin, Huabin
AU  - Yin H
AD  - Department of Orthopedics, Shanghai General Hospital, School of Medicine, 
      Shanghai Jiaotong University, 100 Haining Road, Shanghai, China.
FAU - Xian, Shuyuan
AU  - Xian S
AD  - Tongji University School of Medicine, 1239 Siping Road, Shanghai, 200092, China.
FAU - Li, Man
AU  - Li M
AD  - Department of Orthopedics, The First Affiliated Hospital of Zhengzhou University, 
      1 East Jianshe Road, Zhengzhou, 450052, China.
FAU - Wang, Siqiao
AU  - Wang S
AD  - Tongji University School of Medicine, 1239 Siping Road, Shanghai, 200092, China.
FAU - Li, Zhenyu
AU  - Li Z
AD  - Tongji University School of Medicine, 1239 Siping Road, Shanghai, 200092, China.
FAU - Qiao, Yannan
AU  - Qiao Y
AD  - Department of Orthopedics, The First Affiliated Hospital of Zhengzhou University, 
      1 East Jianshe Road, Zhengzhou, 450052, China.
FAU - Jiang, Meiyun
AU  - Jiang M
AD  - Department of Orthopedics, The First Affiliated Hospital of Zhengzhou University, 
      1 East Jianshe Road, Zhengzhou, 450052, China.
FAU - Yan, Penghui
AU  - Yan P
AD  - Department of Orthopedics, The First Affiliated Hospital of Zhengzhou University, 
      1 East Jianshe Road, Zhengzhou, 450052, China.
FAU - Meng, Tong
AU  - Meng T
AD  - Department of Orthopedics, Shanghai General Hospital, School of Medicine, 
      Shanghai Jiaotong University, 100 Haining Road, Shanghai, China.
AD  - Tongji University Cancer Center, Shanghai Tenth People's Hospital, Tongji 
      University School of Medicine, 301 Yanchang Road, Shanghai, 200072, China.
FAU - Huang, Zongqiang
AU  - Huang Z
AD  - Department of Orthopedics, The First Affiliated Hospital of Zhengzhou University, 
      1 East Jianshe Road, Zhengzhou, 450052, China.
LA  - eng
PT  - Journal Article
DEP - 20220719
PL  - United States
TA  - iScience
JT  - iScience
JID - 101724038
PMC - PMC9385710
OTO - NOTNLM
OT  - Cancer
OT  - Cancer systems biology
OT  - Transcriptomics
COIS- The authors declare that the research was conducted in the absence of any 
      commercial or financial relationships that could be construed as a potential 
      conflict of interest.
EDAT- 2022/08/23 06:00
MHDA- 2022/08/23 06:01
PMCR- 2022/07/19
CRDT- 2022/08/22 04:21
PHST- 2021/07/17 00:00 [received]
PHST- 2022/03/10 00:00 [revised]
PHST- 2022/07/13 00:00 [accepted]
PHST- 2022/08/22 04:21 [entrez]
PHST- 2022/08/23 06:00 [pubmed]
PHST- 2022/08/23 06:01 [medline]
PHST- 2022/07/19 00:00 [pmc-release]
AID - S2589-0042(22)01049-5 [pii]
AID - 104777 [pii]
AID - 10.1016/j.isci.2022.104777 [doi]
PST - epublish
SO  - iScience. 2022 Jul 19;25(8):104777. doi: 10.1016/j.isci.2022.104777. eCollection 
      2022 Aug 19.