PMID- 35992100
OWN - NLM
STAT- MEDLINE
DCOM- 20220823
LR  - 20220829
IS  - 1664-2392 (Print)
IS  - 1664-2392 (Electronic)
IS  - 1664-2392 (Linking)
VI  - 13
DP  - 2022
TI  - Triglyceride glucose index is associated with cerebral small vessel disease 
      burden and cognitive impairment in elderly patients with type 2 diabetes 
      mellitus.
PG  - 970122
LID - 10.3389/fendo.2022.970122 [doi]
LID - 970122
AB  - OBJECTIVE: To investigate the relations of Triglyceride glucose (TyG) index with 
      cerebral small vessel disease (CSVD) burden and cognitive function in aged 
      patients with type 2 diabetes mellitus (T2DM). METHODS: A total of 308 elderly 
      patients with T2DM were included in this retrospective study. The standardized 
      Chinese version of Mini-Mental State Examination was used to assess cognitive 
      function. The total CSVD burden score was assessed by combining four imaging 
      markers of CSVD, including the presence of white matter hyperintensity, cerebral 
      microbleeds in the deep, lacunes and enlarged perivascular spaces in the basal 
      ganglia. The TyG index was calculated as the formula of ln [fasting triglyceride 
      (mg/dl) x fasting plasma glucose (mg/dl)/2]. We used logistic regression analysis 
      and mediation analysis to investigate the relations of TyG index with CSVD and 
      cognitive function. RESULTS: Multivariate binary logistic regression analysis 
      showed that increased TyG index (OR: 2.241; 95% Confidence Interval(CI): 1.439 to 
      3.490; P <0.001), or severe CSVD burden (OR: 2.198; 95% CI: 1.283 to 3.763; P = 
      0.004) was associated with an increased risk of cognitive impairment in elderly 
      patients with T2DM after adjusting for potential confounders. In addition, TyG 
      index was an independent risk factor of severe CSVD burden (OR: 1.472; 95% CI: 
      1.003 to 2.160; P = 0.048) after controlling for potential confounders. Compared 
      with the lowest TyG index tertile, the multivariable-adjusted OR of the highest 
      tertile was 3.298 (95% CI: 1.685 to 6.452; P for trend <0.001) for cognitive 
      impairment, 1.933 (95% CI: 1.010 to 3.698; P for trend = 0.047) for severe CSVD 
      burden. Mediation analysis found a significant moderating effect of the severe 
      CSVD burden on the association between higher TyG index levels and cognitive 
      impairment. CONCLUSIONS: The increased TyG index is an independent risk factor 
      for cognitive impairment and severe CSVD burden in clinical practice. A 
      proportion of the effect of increased TyG index on cognitive impairment may be 
      due to the aggravation of CSVD burden.
CI  - Copyright (c) 2022 Teng, Feng, Dong, Xu, Jiang, Chen, Qi, Li, Chen and Lv.
FAU - Teng, Zhenjie
AU  - Teng Z
AD  - Department of Neurology, Hebei Medical University, Shijiazhuang, China.
AD  - Department of Neurology, Hebei General Hospital, Shijiazhuang, China.
FAU - Feng, Jing
AU  - Feng J
AD  - Department of Endocrinology, Hebei General Hospital, Shijiazhuang, China.
FAU - Dong, Yanhong
AU  - Dong Y
AD  - Department of Neurology, Hebei General Hospital, Shijiazhuang, China.
FAU - Xu, Jing
AU  - Xu J
AD  - Department of Neurology, Hebei General Hospital, Shijiazhuang, China.
FAU - Jiang, Xin
AU  - Jiang X
AD  - Department of Neurology, Hebei General Hospital, Shijiazhuang, China.
FAU - Chen, Huifang
AU  - Chen H
AD  - Department of Neurology, Hebei General Hospital, Shijiazhuang, China.
FAU - Qi, Qianqian
AU  - Qi Q
AD  - Department of Neurology, Hebei Medical University, Shijiazhuang, China.
AD  - Department of Neurology, Hebei General Hospital, Shijiazhuang, China.
FAU - Li, Rui
AU  - Li R
AD  - Department of Neurology, Hebei General Hospital, Shijiazhuang, China.
FAU - Chen, Weihong
AU  - Chen W
AD  - Department of Neurology, Hebei General Hospital, Shijiazhuang, China.
FAU - Lv, Peiyuan
AU  - Lv P
AD  - Department of Neurology, Hebei Medical University, Shijiazhuang, China.
AD  - Department of Neurology, Hebei General Hospital, Shijiazhuang, China.
LA  - eng
PT  - Journal Article
DEP - 20220805
PL  - Switzerland
TA  - Front Endocrinol (Lausanne)
JT  - Frontiers in endocrinology
JID - 101555782
RN  - 0 (Triglycerides)
RN  - IY9XDZ35W2 (Glucose)
SB  - IM
MH  - Aged
MH  - *Cerebral Small Vessel Diseases/complications/diagnostic imaging
MH  - *Cognitive Dysfunction/diagnosis/epidemiology/etiology
MH  - *Diabetes Mellitus, Type 2
MH  - Glucose
MH  - Humans
MH  - Retrospective Studies
MH  - Triglycerides
PMC - PMC9390881
OTO - NOTNLM
OT  - cerebral small vessel disease
OT  - cognitive impairment
OT  - diabetes
OT  - insulin resistance
OT  - triglyceride glucose index
COIS- The authors declare that the research was conducted in the absence of any 
      commercial or financial relationships that could be construed as a potential 
      conflict of interest.
EDAT- 2022/08/23 06:00
MHDA- 2022/08/24 06:00
PMCR- 2022/01/01
CRDT- 2022/08/22 04:22
PHST- 2022/06/15 00:00 [received]
PHST- 2022/07/20 00:00 [accepted]
PHST- 2022/08/22 04:22 [entrez]
PHST- 2022/08/23 06:00 [pubmed]
PHST- 2022/08/24 06:00 [medline]
PHST- 2022/01/01 00:00 [pmc-release]
AID - 10.3389/fendo.2022.970122 [doi]
PST - epublish
SO  - Front Endocrinol (Lausanne). 2022 Aug 5;13:970122. doi: 
      10.3389/fendo.2022.970122. eCollection 2022.