PMID- 35992929
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220823
IS  - 1662-4548 (Print)
IS  - 1662-453X (Electronic)
IS  - 1662-453X (Linking)
VI  - 16
DP  - 2022
TI  - Alteration of brain functional networks induced by electroacupuncture stimulation 
      in rats with ischemia-reperfusion: An independent component analysis.
PG  - 958804
LID - 10.3389/fnins.2022.958804 [doi]
LID - 958804
AB  - Motor dysfunction is the major sequela of ischemic stroke. Motor recovery after 
      stroke has been shown to be associated with remodeling of large-scale brain 
      networks, both functionally and structurally. Electroacupuncture (EA) is a 
      traditional Chinese medicine application that has frequently been recommended as 
      an alternative therapy for ischemic stroke and is reportedly effective for 
      alleviating motor symptoms in patients. In the present study, the effect of EA on 
      the alterations of functional resting state networks (RSNs) was explored after 
      middle cerebral artery occlusion/reperfusion (MCAO/R) injury using resting-state 
      functional MRI. Rats were randomly assigned to three groups, including the sham 
      group, MCAO/R group and MCAO/R+EA group. The ladder rung walking test was 
      conducted prior to and after modeling to assess behavioral changes. RSNs were 
      identified based on the independent component analysis (ICA) performed on the 
      fMRI data from groups. EA treatment effectively reduced the occurrence of 
      contralateral forelimb foot faults. Furthermore, our results suggested the 
      disrupted function of the whole-brain network following ischemic stroke and the 
      modulatory effect of acupuncture. The sensorimotor network (SMN), interoceptive 
      network (IN), default mode network (DMN) and salience network (SN) were related 
      to the therapeutic effect of EA on stroke recovery. Collectively, our findings 
      confirmed the effect of EA on motor function recovery after cerebral ischemia 
      reperfusion and shed light on the assessment of EA intervention-induced effects 
      on brain networks. This study provides neuroimaging evidence to explain the 
      therapeutic effects of EA in ischemic stroke and will lay the groundwork for 
      further studies.
CI  - Copyright (c) 2022 Li, Xing, Hua, Zhang, Wu, Shan, Zheng, Wang and Xu.
FAU - Li, Si-Si
AU  - Li SS
AD  - School of Rehabilitation Science, Shanghai University of Traditional Chinese 
      Medicine, Shanghai, China.
FAU - Xing, Xiang-Xin
AU  - Xing XX
AD  - Center of Rehabilitation Medicine, Yueyang Hospital of Integrated Traditional 
      Chinese and Western Medicine, Shanghai University of Traditional Chinese 
      Medicine, Shanghai, China.
FAU - Hua, Xu-Yun
AU  - Hua XY
AD  - Department of Traumatology and Orthopedics, Yueyang Hospital of Integrated 
      Traditional Chinese and Western Medicine, Shanghai University of Traditional 
      Chinese Medicine, Shanghai, China.
FAU - Zhang, Yu-Wen
AU  - Zhang YW
AD  - Institute of Science and Technology for Brain-Inspired Intelligence, Fudan 
      University, Shanghai, China.
FAU - Wu, Jia-Jia
AU  - Wu JJ
AD  - Center of Rehabilitation Medicine, Yueyang Hospital of Integrated Traditional 
      Chinese and Western Medicine, Shanghai University of Traditional Chinese 
      Medicine, Shanghai, China.
FAU - Shan, Chun-Lei
AU  - Shan CL
AD  - School of Rehabilitation Science, Shanghai University of Traditional Chinese 
      Medicine, Shanghai, China.
AD  - Center of Rehabilitation Medicine, Yueyang Hospital of Integrated Traditional 
      Chinese and Western Medicine, Shanghai University of Traditional Chinese 
      Medicine, Shanghai, China.
AD  - Engineering Research Center of Traditional Chinese Medicine Intelligent 
      Rehabilitation, Ministry of Education, Shanghai, China.
FAU - Zheng, Mou-Xiong
AU  - Zheng MX
AD  - Department of Traumatology and Orthopedics, Yueyang Hospital of Integrated 
      Traditional Chinese and Western Medicine, Shanghai University of Traditional 
      Chinese Medicine, Shanghai, China.
FAU - Wang, He
AU  - Wang H
AD  - Institute of Science and Technology for Brain-Inspired Intelligence, Fudan 
      University, Shanghai, China.
FAU - Xu, Jian-Guang
AU  - Xu JG
AD  - School of Rehabilitation Science, Shanghai University of Traditional Chinese 
      Medicine, Shanghai, China.
AD  - Engineering Research Center of Traditional Chinese Medicine Intelligent 
      Rehabilitation, Ministry of Education, Shanghai, China.
LA  - eng
PT  - Journal Article
DEP - 20220803
PL  - Switzerland
TA  - Front Neurosci
JT  - Frontiers in neuroscience
JID - 101478481
PMC - PMC9382119
OTO - NOTNLM
OT  - electroacupuncture
OT  - independent component analysis
OT  - ischemic stroke
OT  - motor function
OT  - resting state networks
COIS- The authors declare that the research was conducted in the absence of any 
      commercial or financial relationships that could be construed as a potential 
      conflict of interest.
EDAT- 2022/08/23 06:00
MHDA- 2022/08/23 06:01
PMCR- 2022/01/01
CRDT- 2022/08/22 04:35
PHST- 2022/06/01 00:00 [received]
PHST- 2022/07/11 00:00 [accepted]
PHST- 2022/08/22 04:35 [entrez]
PHST- 2022/08/23 06:00 [pubmed]
PHST- 2022/08/23 06:01 [medline]
PHST- 2022/01/01 00:00 [pmc-release]
AID - 10.3389/fnins.2022.958804 [doi]
PST - epublish
SO  - Front Neurosci. 2022 Aug 3;16:958804. doi: 10.3389/fnins.2022.958804. eCollection 
      2022.