PMID- 35993213
OWN - NLM
STAT- MEDLINE
DCOM- 20220823
LR  - 20220823
IS  - 0371-0874 (Print)
IS  - 0371-0874 (Linking)
VI  - 74
IP  - 4
DP  - 2022 Aug 25
TI  - Anti-epileptic/pro-epileptic effects of sodium channel modulators from Buthus 
      martensii Karsch.
PG  - 621-632
AB  - The East Asian scorpion Buthus martensii Karsch (BmK) is one of the classical 
      traditional Chinese medicines for treating epilepsy for over a thousand years. 
      Neurotoxins purified from BmK venom are considered as the main active 
      ingredients, acting on membrane ion channels. Voltage-gated sodium channels 
      (VGSCs) play a crucial role in the occurrence of epilepsy, which make them become 
      important drug targets for epilepsy. Long chain toxins of BmK, composed of 60-70 
      amino acid residues, could specifically recognize VGSCs. Among them, alpha-like 
      neurotoxins, binding to the receptor site-3 of VGSC, induce epilepsy in rodents 
      and can be used to establish seizure models. The beta or beta-like neurotoxins, binding 
      to the receptor site-4 of VGSC, have significant anticonvulsant effects in 
      epileptic models. This review aims to illuminate the anticonvulsant/convulsant 
      effects of BmK polypeptides by acting on VGSCs, and provide potential frameworks 
      for the anti-epileptic drug-design.
FAU - Xiao, Qian
AU  - Xiao Q
AD  - Department of Neurology and Central Laboratory, Putuo Hospital, Shanghai 
      University of Traditional Chinese Medicine, Shanghai 200333, China.
FAU - Zhang, Zhi-Ping
AU  - Zhang ZP
AD  - School of Medicine and School of Life Sciences, Shanghai University, Shanghai 
      200444, China.
FAU - Hou, Yang-Bo
AU  - Hou YB
AD  - Department of Neurology and Central Laboratory, Putuo Hospital, Shanghai 
      University of Traditional Chinese Medicine, Shanghai 200333, China.
FAU - Qu, Dong-Xiao
AU  - Qu DX
AD  - Department of Neurology and Central Laboratory, Putuo Hospital, Shanghai 
      University of Traditional Chinese Medicine, Shanghai 200333, China.
FAU - Tang, Le-Le
AU  - Tang LL
AD  - Department of Neurology and Central Laboratory, Putuo Hospital, Shanghai 
      University of Traditional Chinese Medicine, Shanghai 200333, China.
AD  - Putuo Clinical Medical School, Anhui Medical University, Shanghai 200333, China.
FAU - Chen, Li-Ji
AU  - Chen LJ
AD  - Department of Neurology and Central Laboratory, Putuo Hospital, Shanghai 
      University of Traditional Chinese Medicine, Shanghai 200333, China.
FAU - Li, Guo-Yi
AU  - Li GY
AD  - Department of Neurology and Central Laboratory, Putuo Hospital, Shanghai 
      University of Traditional Chinese Medicine, Shanghai 200333, China.
AD  - Putuo Clinical Medical School, Anhui Medical University, Shanghai 200333, China.
FAU - Ji, Yong-Hua
AU  - Ji YH
AD  - School of Medicine and School of Life Sciences, Shanghai University, Shanghai 
      200444, China.
FAU - Tao, Jie
AU  - Tao J
AD  - Department of Neurology and Central Laboratory, Putuo Hospital, Shanghai 
      University of Traditional Chinese Medicine, Shanghai 200333, China.
AD  - Putuo Clinical Medical School, Anhui Medical University, Shanghai 200333, China. 
      jietao_putuo@foxmail.com.
FAU - Zhu, Yu-Dan
AU  - Zhu YD
AD  - Department of Neurology and Central Laboratory, Putuo Hospital, Shanghai 
      University of Traditional Chinese Medicine, Shanghai 200333, China.
AD  - Putuo Clinical Medical School, Anhui Medical University, Shanghai 200333, China. 
      yudanzhu_putuo@foxmail.com.
LA  - eng
PT  - Journal Article
PT  - Review
PL  - China
TA  - Sheng Li Xue Bao
JT  - Sheng li xue bao : [Acta physiologica Sinica]
JID - 20730130R
RN  - 0 (Anticonvulsants)
RN  - 0 (Neurotoxins)
RN  - 0 (Scorpion Venoms)
RN  - 0 (Voltage-Gated Sodium Channels)
SB  - IM
MH  - Animals
MH  - Anticonvulsants/pharmacology/therapeutic use
MH  - Neurotoxins/chemistry/pharmacology
MH  - *Scorpion Venoms/chemistry/pharmacology
MH  - Scorpions/chemistry
MH  - *Voltage-Gated Sodium Channels
EDAT- 2022/08/23 06:00
MHDA- 2022/08/24 06:00
CRDT- 2022/08/22 04:53
PHST- 2022/08/22 04:53 [entrez]
PHST- 2022/08/23 06:00 [pubmed]
PHST- 2022/08/24 06:00 [medline]
PST - ppublish
SO  - Sheng Li Xue Bao. 2022 Aug 25;74(4):621-632.