PMID- 35995159
OWN - NLM
STAT- MEDLINE
DCOM- 20230328
LR  - 20230328
IS  - 1879-1026 (Electronic)
IS  - 0048-9697 (Linking)
VI  - 851
IP  - Pt 1
DP  - 2022 Dec 10
TI  - nTiO(2) alleviates the toxic effects of TCPP on mussels by adjusting respiratory 
      metabolism and gut microbiota.
PG  - 158176
LID - S0048-9697(22)05275-5 [pii]
LID - 10.1016/j.scitotenv.2022.158176 [doi]
AB  - As a good carrier of contaminants, nanotitanium dioxide (nTiO(2)) can absorb 
      organic pollutants, producing toxicological effects on organisms. However, the 
      complex effects of nTiO(2) with contaminants on marine mussels are still unclear. 
      In this study, we exposed mussels to tris (2-chloropropyl) phosphate (TCPP) 100 
      mug/L (T1), 0.5 mg/L nTiO(2) + 100 mug/L TCPP (T2), 1.0 mg/L nTiO(2) + 100 mug/L 
      TCPP (T3) and control (0 nTiO(2) + 0 mug/L TCPP) treatments, and assessed the 
      combined effects of TCPP with nTiO(2) on the thick-shelled mussel Mytilus 
      coruscus by detecting the activities of gill pyruvate kinase (PK), hexokinase 
      (HK), lactate dehydrogenase (LDH) and succinate dehydrogenase (SDH), also gill 
      acetylcholine (Ach) and muscle lactic acid (LD) contents and gut microbiota after 
      14-d exposure. Compared with the control group, PK activity was increased 
      significantly, but SDH, LDH activities and LD content were decreased 
      significantly in T1, with the addition of nTiO(2), there were not significantly 
      different in T3. However, Ach content in T3 was significantly higher than the 
      control and T1. Moreover, KEGG of the gut microbiota via 16 s rRNA sequencing 
      showed that most pathways returned to the control level in T3. The results showed 
      that TCPP affected the respiratory metabolism of mussels, changed the community 
      structure of intestinal microflora in mussels, and nTiO(2) alleviated the 
      toxicity of TCPP. Our study provides new insights for ecological risk assessment 
      of TCPP in bivalves in the complex aquatic environment and the novel role of 
      nTiO(2) in regulating the toxicity of TCPP.
CI  - Copyright (c) 2022 Elsevier B.V. All rights reserved.
FAU - Deng, Fujing
AU  - Deng F
AD  - International Research Center for Marine Biosciences, Shanghai Ocean University, 
      Ministry of Science and Technology, China; Key Laboratory of Exploration and 
      Utilization of Aquatic Genetic Resources, Ministry of Education, Shanghai Ocean 
      University, Shanghai 201306, China.
FAU - Liu, Jiani
AU  - Liu J
AD  - International Research Center for Marine Biosciences, Shanghai Ocean University, 
      Ministry of Science and Technology, China; Key Laboratory of Exploration and 
      Utilization of Aquatic Genetic Resources, Ministry of Education, Shanghai Ocean 
      University, Shanghai 201306, China.
FAU - Xie, Zhe
AU  - Xie Z
AD  - International Research Center for Marine Biosciences, Shanghai Ocean University, 
      Ministry of Science and Technology, China; Key Laboratory of Exploration and 
      Utilization of Aquatic Genetic Resources, Ministry of Education, Shanghai Ocean 
      University, Shanghai 201306, China.
FAU - Li, Saishuai
AU  - Li S
AD  - International Research Center for Marine Biosciences, Shanghai Ocean University, 
      Ministry of Science and Technology, China; Key Laboratory of Exploration and 
      Utilization of Aquatic Genetic Resources, Ministry of Education, Shanghai Ocean 
      University, Shanghai 201306, China.
FAU - Hu, Menghong
AU  - Hu M
AD  - International Research Center for Marine Biosciences, Shanghai Ocean University, 
      Ministry of Science and Technology, China; Key Laboratory of Exploration and 
      Utilization of Aquatic Genetic Resources, Ministry of Education, Shanghai Ocean 
      University, Shanghai 201306, China.
FAU - Lin, Daohui
AU  - Lin D
AD  - Zhejiang Provincial Key Laboratory of Organic Pollution Process and Control, 
      Department of Environmental Science, Zhejiang University, Hangzhou 310058, China. 
      Electronic address: lindaohui@zju.edu.cn.
FAU - Wang, Youji
AU  - Wang Y
AD  - International Research Center for Marine Biosciences, Shanghai Ocean University, 
      Ministry of Science and Technology, China; Key Laboratory of Exploration and 
      Utilization of Aquatic Genetic Resources, Ministry of Education, Shanghai Ocean 
      University, Shanghai 201306, China. Electronic address: youjiwang2@gmail.com.
LA  - eng
PT  - Journal Article
DEP - 20220819
PL  - Netherlands
TA  - Sci Total Environ
JT  - The Science of the total environment
JID - 0330500
RN  - N9YNS0M02X (Acetylcholine)
RN  - EC 2.7.1.1 (Hexokinase)
RN  - EC 1.1.- (Lactate Dehydrogenases)
RN  - 33X04XA5AT (Lactic Acid)
RN  - 0 (Phosphates)
RN  - EC 2.7.1.40 (Pyruvate Kinase)
RN  - EC 1.3.99.1 (Succinate Dehydrogenase)
RN  - D1JT611TNE (Titanium)
RN  - 0 (Water Pollutants, Chemical)
RN  - 13674-84-5 (tri-(2-chloroisopropyl)phosphate)
SB  - IM
MH  - Animals
MH  - Acetylcholine
MH  - *Gastrointestinal Microbiome
MH  - Hexokinase/metabolism
MH  - Lactate Dehydrogenases/metabolism
MH  - Lactic Acid
MH  - *Mytilus/metabolism
MH  - Phosphates/metabolism
MH  - Pyruvate Kinase/metabolism
MH  - Succinate Dehydrogenase/metabolism
MH  - Titanium/chemistry
MH  - *Water Pollutants, Chemical/analysis
OTO - NOTNLM
OT  - Gut microbiota
OT  - Respiratory metabolism
OT  - TCPP
OT  - nTiO(2)
COIS- Declaration of competing interest The authors declare that they have no known 
      competing financial interests or personal relationships that could have appeared 
      to influence the work reported in this paper.
EDAT- 2022/08/23 06:00
MHDA- 2022/10/20 06:00
CRDT- 2022/08/22 19:32
PHST- 2022/07/20 00:00 [received]
PHST- 2022/08/16 00:00 [revised]
PHST- 2022/08/16 00:00 [accepted]
PHST- 2022/08/23 06:00 [pubmed]
PHST- 2022/10/20 06:00 [medline]
PHST- 2022/08/22 19:32 [entrez]
AID - S0048-9697(22)05275-5 [pii]
AID - 10.1016/j.scitotenv.2022.158176 [doi]
PST - ppublish
SO  - Sci Total Environ. 2022 Dec 10;851(Pt 1):158176. doi: 
      10.1016/j.scitotenv.2022.158176. Epub 2022 Aug 19.