PMID- 35995457
OWN - NLM
STAT- MEDLINE
DCOM- 20221220
LR  - 20240203
IS  - 1029-2403 (Electronic)
IS  - 1026-8022 (Linking)
VI  - 63
IP  - 13
DP  - 2022 Dec
TI  - Clinicopathologic and genetic evaluation of B-lymphoblastic leukemia with 
      intrachromosomal amplification of chromosome 21 (iAMP21) in adult patients.
PG  - 3200-3207
LID - 10.1080/10428194.2022.2113524 [doi]
AB  - Intrachromosomal amplification of chromosome 21 (iAMP21) defines a rare 
      provisional entity of B-cell acute lymphoblastic leukemia (B-ALL) in the current 
      WHO classification and has been described as specific for pediatric patients with 
      a median age at diagnosis of 9-10 years. We report two adult cases of B-ALL with 
      iAMP21, one 31-year-old woman and one 40-year-old man, identified by karyotyping 
      and next generation sequencing (NGS), with fluorescence in situ hybridization 
      (FISH) pattern meeting diagnostic criteria for iAMP21. Both patients were treated 
      on high-risk chemotherapeutic regimen followed by stem cell transplant. In 
      contrast to reported high relapse rate within the first three years in pediatric 
      population, our adult patients are alive in remission, with the interval from 
      diagnosis to last follow up of 2.95 and 3.96 years. Our cases illustrate the 
      importance of screening for iAMP21 in adult population when ETV6-RUNX1 FISH 
      testing is not routinely performed for adult patients.
FAU - Zak, Taylor
AU  - Zak T
AD  - Department of Pathology, Northwestern University Feinberg School of Medicine, 
      Chicago, IL, USA.
FAU - Gao, Juehua
AU  - Gao J
AD  - Department of Pathology, Northwestern University Feinberg School of Medicine, 
      Chicago, IL, USA.
FAU - Behdad, Amir
AU  - Behdad A
AD  - Department of Pathology, Northwestern University Feinberg School of Medicine, 
      Chicago, IL, USA.
AD  - Department of Hematology and Oncology, Northwestern University Feinberg School of 
      Medicine, Chicago, IL, USA.
FAU - Mehta, Jayesh
AU  - Mehta J
AD  - Department of Hematology and Oncology, Northwestern University Feinberg School of 
      Medicine, Chicago, IL, USA.
FAU - Altman, Jessica K
AU  - Altman JK
AD  - Department of Hematology and Oncology, Northwestern University Feinberg School of 
      Medicine, Chicago, IL, USA.
FAU - Ji, Peng
AU  - Ji P
AD  - Department of Pathology, Northwestern University Feinberg School of Medicine, 
      Chicago, IL, USA.
FAU - Lu, Xinyan
AU  - Lu X
AD  - Department of Pathology, Northwestern University Feinberg School of Medicine, 
      Chicago, IL, USA.
FAU - Sukhanova, Madina
AU  - Sukhanova M
AUID- ORCID: 0000-0002-1843-7038
AD  - Department of Pathology, Northwestern University Feinberg School of Medicine, 
      Chicago, IL, USA.
LA  - eng
GR  - R01 DK102718/DK/NIDDK NIH HHS/United States
GR  - R01 HL148012/HL/NHLBI NIH HHS/United States
GR  - R01 AI148012/AI/NIAID NIH HHS/United States
PT  - Case Reports
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
DEP - 20220822
PL  - United States
TA  - Leuk Lymphoma
JT  - Leukemia & lymphoma
JID - 9007422
SB  - IM
MH  - Child
MH  - Humans
MH  - In Situ Hybridization, Fluorescence
MH  - Chromosomes, Human, Pair 21/genetics
MH  - *Precursor B-Cell Lymphoblastic Leukemia-Lymphoma/diagnosis/genetics/therapy
MH  - Chromosome Aberrations
MH  - *Leukemia, B-Cell
OTO - NOTNLM
OT  - B-cell ALL
OT  - iAMP21, FISH testing
EDAT- 2022/08/23 06:00
MHDA- 2022/12/21 06:00
CRDT- 2022/08/22 20:52
PHST- 2022/08/23 06:00 [pubmed]
PHST- 2022/12/21 06:00 [medline]
PHST- 2022/08/22 20:52 [entrez]
AID - 10.1080/10428194.2022.2113524 [doi]
PST - ppublish
SO  - Leuk Lymphoma. 2022 Dec;63(13):3200-3207. doi: 10.1080/10428194.2022.2113524. 
      Epub 2022 Aug 22.