PMID- 35995968
OWN - NLM
STAT- MEDLINE
DCOM- 20220824
LR  - 20221117
IS  - 2045-2322 (Electronic)
IS  - 2045-2322 (Linking)
VI  - 12
IP  - 1
DP  - 2022 Aug 22
TI  - Saliva microbiome, dietary, and genetic markers are associated with suicidal 
      ideation in university students.
PG  - 14306
LID - 10.1038/s41598-022-18020-2 [doi]
LID - 14306
AB  - Here, salivary microbiota and major histocompatibility complex (MHC) human 
      leukocyte antigen (HLA) alleles were compared between 47 (12.6%) young adults 
      with recent suicidal ideation (SI) and 325 (87.4%) controls without recent SI. 
      Several bacterial taxa were correlated with SI after controlling for sleep 
      issues, diet, and genetics. Four MHC class II alleles were protective for SI 
      including DRB1*04, which was absent in every subject with SI while present in 
      21.7% of controls. Increased incidence of SI was observed with four other MHC 
      class II alleles and two MHC class I alleles. Associations between these HLA 
      alleles and salivary bacteria were also identified. Furthermore, rs10437629, 
      previously associated with attempted suicide, was correlated here with SI and the 
      absence of Alloprevotella rava, a producer of an organic acid known to promote 
      brain energy homeostasis. Hence, microbial-genetic associations may be important 
      players in the diathesis-stress model for suicidal behaviors.
CI  - (c) 2022. The Author(s).
FAU - Ahrens, Angelica P
AU  - Ahrens AP
AD  - Microbiology and Cell Science Department, Institute of Food and Agricultural 
      Sciences, University of Florida, Gainesville, FL, USA.
FAU - Sanchez-Padilla, Diego E
AU  - Sanchez-Padilla DE
AD  - Microbiology and Cell Science Department, Institute of Food and Agricultural 
      Sciences, University of Florida, Gainesville, FL, USA.
FAU - Drew, Jennifer C
AU  - Drew JC
AD  - Microbiology and Cell Science Department, Institute of Food and Agricultural 
      Sciences, University of Florida, Gainesville, FL, USA.
FAU - Oli, Monika W
AU  - Oli MW
AD  - Microbiology and Cell Science Department, Institute of Food and Agricultural 
      Sciences, University of Florida, Gainesville, FL, USA.
FAU - Roesch, Luiz F W
AU  - Roesch LFW
AD  - Microbiology and Cell Science Department, Institute of Food and Agricultural 
      Sciences, University of Florida, Gainesville, FL, USA.
FAU - Triplett, Eric W
AU  - Triplett EW
AD  - Microbiology and Cell Science Department, Institute of Food and Agricultural 
      Sciences, University of Florida, Gainesville, FL, USA. ewt@ufl.edu.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, Non-P.H.S.
DEP - 20220822
PL  - England
TA  - Sci Rep
JT  - Scientific reports
JID - 101563288
RN  - 0 (Genetic Markers)
RN  - 0 (HLA Antigens)
RN  - 0 (HLA-DRB1 Chains)
RN  - 0 (Histocompatibility Antigens Class II)
SB  - IM
MH  - Alleles
MH  - Diet
MH  - Genetic Markers
MH  - Genetic Predisposition to Disease
MH  - HLA Antigens
MH  - HLA-DRB1 Chains/genetics
MH  - Histocompatibility Antigens Class II/genetics
MH  - Humans
MH  - *Microbiota/genetics
MH  - Saliva
MH  - Students
MH  - *Suicidal Ideation
MH  - Universities
MH  - Young Adult
PMC - PMC9395396
COIS- The authors declare no competing interests.
EDAT- 2022/08/23 06:00
MHDA- 2022/08/25 06:00
PMCR- 2022/08/22
CRDT- 2022/08/22 23:28
PHST- 2021/11/25 00:00 [received]
PHST- 2022/08/03 00:00 [accepted]
PHST- 2022/08/22 23:28 [entrez]
PHST- 2022/08/23 06:00 [pubmed]
PHST- 2022/08/25 06:00 [medline]
PHST- 2022/08/22 00:00 [pmc-release]
AID - 10.1038/s41598-022-18020-2 [pii]
AID - 18020 [pii]
AID - 10.1038/s41598-022-18020-2 [doi]
PST - epublish
SO  - Sci Rep. 2022 Aug 22;12(1):14306. doi: 10.1038/s41598-022-18020-2.