PMID- 35996062
OWN - NLM
STAT- MEDLINE
DCOM- 20221222
LR  - 20230105
IS  - 2509-2723 (Electronic)
IS  - 2509-2715 (Print)
IS  - 2509-2723 (Linking)
VI  - 44
IP  - 5
DP  - 2022 Oct
TI  - Replenishment of myeloid-derived suppressor cells (MDSCs) overrides CR-mediated 
      protection against tumor growth in a murine model of triple-negative breast 
      cancer.
PG  - 2471-2490
LID - 10.1007/s11357-022-00635-y [doi]
AB  - Caloric restriction (CR) is the leading non-pharmacological intervention to delay 
      induced and spontaneous tumors in pre-clinical models. These effects of CR are 
      largely attributed to canonical inhibition of pro-growth pathways. However, our 
      recent data suggest that CR impairs primary tumor growth and cancer progression 
      in the murine 4T1 model of triple negative breast cancer (TNBC), at least in 
      part, through reduced frequency of the myeloid-derived suppressor cells (MDSC). 
      In the present study, we sought to determine whether injection of excess MDSCs 
      could block regression in 4T1 tumor growth and metastatic spread in BALB/cJ 
      female mice undergoing daily CR. Our findings show that MDSC injection impeded 
      CR-mediated protection against tumor growth without increasing lung metastatic 
      burden. Overall, these results reveal that CR can slow cancer progression by 
      affecting immune suppressive cells.Impact statement: Inoculation of MDSCs from 
      donor mice effectively impedes the ability of calorie restriction to protect 
      against primary tumor growth without impacting lung metastatic burden in 
      recipient animals.
CI  - (c) 2022. This is a U.S. Government work and not under copyright protection in the 
      US; foreign copyright protection may apply.
FAU - Pomatto-Watson, Laura C D
AU  - Pomatto-Watson LCD
AD  - Experimental Gerontology Section, Translational Gerontology Branch, National 
      Institute On Aging, National Institutes of Health, Baltimore, MD, 21224, USA.
FAU - Bodogai, Monica
AU  - Bodogai M
AD  - Immunoregulation Section, Laboratory of Molecular Biology and Immunology, 
      National Institute On Aging, National Institutes of Health, Baltimore, MD, 21224, 
      USA.
FAU - Carpenter, Melissa
AU  - Carpenter M
AD  - Experimental Gerontology Section, Translational Gerontology Branch, National 
      Institute On Aging, National Institutes of Health, Baltimore, MD, 21224, USA.
FAU - Chowdhury, Dolly
AU  - Chowdhury D
AD  - Experimental Gerontology Section, Translational Gerontology Branch, National 
      Institute On Aging, National Institutes of Health, Baltimore, MD, 21224, USA.
FAU - Krishna, Priya
AU  - Krishna P
AD  - Experimental Gerontology Section, Translational Gerontology Branch, National 
      Institute On Aging, National Institutes of Health, Baltimore, MD, 21224, USA.
FAU - Ng, Sandy
AU  - Ng S
AD  - Experimental Gerontology Section, Translational Gerontology Branch, National 
      Institute On Aging, National Institutes of Health, Baltimore, MD, 21224, USA.
FAU - Bosompra, Oye
AU  - Bosompra O
AD  - Experimental Gerontology Section, Translational Gerontology Branch, National 
      Institute On Aging, National Institutes of Health, Baltimore, MD, 21224, USA.
FAU - Kato, Jonathan
AU  - Kato J
AD  - Experimental Gerontology Section, Translational Gerontology Branch, National 
      Institute On Aging, National Institutes of Health, Baltimore, MD, 21224, USA.
FAU - Wong, Sarah
AU  - Wong S
AD  - Experimental Gerontology Section, Translational Gerontology Branch, National 
      Institute On Aging, National Institutes of Health, Baltimore, MD, 21224, USA.
FAU - Reyes-Sepulveda, Carlos
AU  - Reyes-Sepulveda C
AD  - Experimental Gerontology Section, Translational Gerontology Branch, National 
      Institute On Aging, National Institutes of Health, Baltimore, MD, 21224, USA.
FAU - Bernier, Michel
AU  - Bernier M
AD  - Experimental Gerontology Section, Translational Gerontology Branch, National 
      Institute On Aging, National Institutes of Health, Baltimore, MD, 21224, USA.
FAU - Price, Nathan L
AU  - Price NL
AD  - Experimental Gerontology Section, Translational Gerontology Branch, National 
      Institute On Aging, National Institutes of Health, Baltimore, MD, 21224, USA.
FAU - Biragyn, Arya
AU  - Biragyn A
AD  - Immunoregulation Section, Laboratory of Molecular Biology and Immunology, 
      National Institute On Aging, National Institutes of Health, Baltimore, MD, 21224, 
      USA.
FAU - de Cabo, Rafael
AU  - de Cabo R
AUID- ORCID: 0000-0003-2830-5693
AD  - Experimental Gerontology Section, Translational Gerontology Branch, National 
      Institute On Aging, National Institutes of Health, Baltimore, MD, 21224, USA. 
      decabora@mail.nih.gov.
LA  - eng
GR  - FI2 GM123963/GM/NIGMS NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, N.I.H., Intramural
DEP - 20220823
PL  - Switzerland
TA  - Geroscience
JT  - GeroScience
JID - 101686284
SB  - IM
MH  - Humans
MH  - Female
MH  - Mice
MH  - Animals
MH  - *Myeloid-Derived Suppressor Cells/metabolism/pathology
MH  - *Triple Negative Breast Neoplasms/metabolism/pathology
MH  - Caloric Restriction
MH  - Disease Models, Animal
MH  - Cell Line, Tumor
PMC - PMC9768076
OTO - NOTNLM
OT  - Breast Cancer
OT  - Caloric Restriction
OT  - Fasting Mimicking Diet
OT  - Myeloid-derived suppressor cells
OT  - metastasis
COIS- The authors declare no competing interests.
EDAT- 2022/08/23 06:00
MHDA- 2022/12/23 06:00
PMCR- 2022/08/23
CRDT- 2022/08/22 23:33
PHST- 2022/06/10 00:00 [received]
PHST- 2022/07/28 00:00 [accepted]
PHST- 2022/08/23 06:00 [pubmed]
PHST- 2022/12/23 06:00 [medline]
PHST- 2022/08/22 23:33 [entrez]
PHST- 2022/08/23 00:00 [pmc-release]
AID - 10.1007/s11357-022-00635-y [pii]
AID - 635 [pii]
AID - 10.1007/s11357-022-00635-y [doi]
PST - ppublish
SO  - Geroscience. 2022 Oct;44(5):2471-2490. doi: 10.1007/s11357-022-00635-y. Epub 2022 
      Aug 23.