PMID- 35997243
OWN - NLM
STAT- MEDLINE
DCOM- 20230526
LR  - 20230526
IS  - 1478-6427 (Electronic)
IS  - 1478-6419 (Linking)
VI  - 37
IP  - 12
DP  - 2023 Jun
TI  - Bauhinia forficata link extract attenuates insulin resistance by preserving 
      glucose uptake in gastrocnemius muscle.
PG  - 2031-2036
LID - 10.1080/14786419.2022.2113875 [doi]
AB  - Bioactive metabolites from Bauhinia forficata Link (Bf extract) hold therapeutic 
      potential for type 2 diabetes mellitus (T2DM) but the mechanism remains poorly 
      understood. This study aimed to test the extract from Bf leaves obtained by 
      decoction on the prevention of T2DM in vivo. The Bf extract was tested on a 
      streptozotocin-induced T2DM mouse model fed on a high-fat diet. The insulin 
      resistance was attenuated in T2DM animals supplemented with Bf extract, which 
      indicates glucose intolerance reduction and p-AKT/AKT ratio preservation in the 
      gastrocnemius muscle. These observations suggested that Bf extract enhanced 
      glucose uptake. Nevertheless, there was no preservation in beta-cell insulin 
      secretion in Bf extract-treated T2DM mice. Interestingly, the Bf extract reduced 
      body weight gain without affecting total energy intake. Hence, Bf extract has a 
      hypoglycemic effect which could attenuate the development of insulin resistance.
FAU - Gasparini, Patricia
AU  - Gasparini P
AUID- ORCID: 0000-0002-7576-5409
AD  - Departamento de Ciencias Biologicas; Instituto de Ciencias Ambientais, Quimicas e 
      Farmaceuticas (ICAQF); Universidade Federal de Sao Paulo; Diadema, Brazil.
FAU - Garofolo, Ingrid Candido
AU  - Garofolo IC
AD  - Departamento de Ciencias Biologicas; Instituto de Ciencias Ambientais, Quimicas e 
      Farmaceuticas (ICAQF); Universidade Federal de Sao Paulo; Diadema, Brazil.
FAU - Telles, Monica Marques
AU  - Telles MM
AUID- ORCID: 0000-0003-4342-6688
AD  - Departamento de Ciencias Biologicas; Instituto de Ciencias Ambientais, Quimicas e 
      Farmaceuticas (ICAQF); Universidade Federal de Sao Paulo; Diadema, Brazil.
FAU - Oyama, Lila Missae
AU  - Oyama LM
AUID- ORCID: 0000-0002-7078-6526
AD  - Departamento de Fisiologia, Escola Paulista de Medicina, Universidade Federal de 
      Sao Paulo (UNIFESP), Sao Paulo, Brazil.
FAU - Veneza, Viviane de Mello
AU  - Veneza VM
AD  - Departamento de Quimica; Instituto de Ciencias Ambientais, Quimicas e 
      Farmaceuticas (ICAQF); Universidade Federal de Sao Paulo, Diadema, Brazil.
FAU - Moura Veiga, Thiago Andre
AU  - Moura Veiga TA
AUID- ORCID: 0000-0002-1377-158X
AD  - Departamento de Quimica; Instituto de Ciencias Ambientais, Quimicas e 
      Farmaceuticas (ICAQF); Universidade Federal de Sao Paulo, Diadema, Brazil.
FAU - Flor Silveira, Vera Lucia
AU  - Flor Silveira VL
AD  - Departamento de Ciencias Biologicas; Instituto de Ciencias Ambientais, Quimicas e 
      Farmaceuticas (ICAQF); Universidade Federal de Sao Paulo; Diadema, Brazil.
FAU - Caperuto, Luciana Chagas
AU  - Caperuto LC
AUID- ORCID: 0000-0002-6008-4010
AD  - Departamento de Ciencias Biologicas; Instituto de Ciencias Ambientais, Quimicas e 
      Farmaceuticas (ICAQF); Universidade Federal de Sao Paulo; Diadema, Brazil.
LA  - eng
PT  - Journal Article
DEP - 20220823
PL  - England
TA  - Nat Prod Res
JT  - Natural product research
JID - 101167924
RN  - EC 2.7.11.1 (Proto-Oncogene Proteins c-akt)
RN  - 0 (Hypoglycemic Agents)
RN  - IY9XDZ35W2 (Glucose)
RN  - 0 (Insulin)
RN  - 0 (Blood Glucose)
SB  - IM
MH  - Mice
MH  - Animals
MH  - *Insulin Resistance
MH  - *Diabetes Mellitus, Type 2/drug therapy
MH  - *Bauhinia
MH  - Proto-Oncogene Proteins c-akt
MH  - Hypoglycemic Agents
MH  - Glucose
MH  - Muscle, Skeletal/metabolism
MH  - Insulin
MH  - Blood Glucose/metabolism
OTO - NOTNLM
OT  - Decoction
OT  - Kaempferitrin
OT  - high-fat diet
OT  - hypoglycemic effect
OT  - insulin resistance
OT  - p-AKT/AKT
OT  - streptozotocin
EDAT- 2022/08/24 06:00
MHDA- 2023/05/26 06:42
CRDT- 2022/08/23 07:42
PHST- 2023/05/26 06:42 [medline]
PHST- 2022/08/24 06:00 [pubmed]
PHST- 2022/08/23 07:42 [entrez]
AID - 10.1080/14786419.2022.2113875 [doi]
PST - ppublish
SO  - Nat Prod Res. 2023 Jun;37(12):2031-2036. doi: 10.1080/14786419.2022.2113875. Epub 
      2022 Aug 23.