PMID- 35998706
OWN - NLM
STAT- MEDLINE
DCOM- 20221216
LR  - 20221222
IS  - 1931-3543 (Electronic)
IS  - 0012-3692 (Linking)
VI  - 162
IP  - 6
DP  - 2022 Dec
TI  - Multimodal Telemonitoring for Weight Reduction in Patients With Sleep Apnea: A 
      Randomized Controlled Trial.
PG  - 1373-1383
LID - S0012-3692(22)03651-0 [pii]
LID - 10.1016/j.chest.2022.07.032 [doi]
AB  - BACKGROUND: Telemonitoring the use of CPAP devices and remote feedback on device 
      data effectively optimizes CPAP adherence in patients with OSA. RESEARCH 
      QUESTION: Can expanding the scope of telemonitoring and remote feedback to body 
      weight (BW), BP, and physical activity enhance efforts for BW reduction in 
      Patients with OSA receiving CPAP? STUDY DESIGN AND METHODS: Participants were 
      recruited from patients at 16 sleep centers in Japan with OSA and obesity who 
      were receiving CPAP therapy. Obesity was defined as a BMI of >/= 25 kg/m(2), based 
      on Japanese obesity guidelines. Implementation of CPAP telemonitoring was 
      enhanced with electronic scales, BP monitors, and pedometers that could transmit 
      data from devices wirelessly. Participants were randomized to the multimodal 
      telemonitoring group or the usual CPAP telemonitoring group and were followed up 
      for 6 months. Attending physicians provided monthly telephone feedback calls to 
      the usual CPAP telemonitoring group on CPAP data obtained remotely. In the 
      multimodal telemonitoring group, physicians additionally encouraged participants 
      to reduce their BW, after sharing the remotely obtained data on BW, BP, and step 
      count. The primary outcome was set as >/= 3% BW reduction from baseline. RESULTS: 
      One hundred sixty-eight participants (BMI, 31.7 +/- 4.9 kg/m(2)) completed the 
      study, and >/= 3% BW reduction occurred in 33 of 84 participants (39.3%) and 21 of 
      84 participants (25.0%) in the multimodal telemonitoring and usual CPAP 
      telemonitoring groups, respectively (P = .047). Whereas no significant 
      differences were found between the two groups in the change in office and home 
      BP, daily step counts during the study period were significantly higher in the 
      multimodal telemonitoring group than in the usual CPAP telemonitoring group 
      (4,767 steps/d [interquartile range (IQR), 2,864-6,617 steps/d] vs 3,592 steps/d 
      [IQR, 2,117-5,383 steps/d]; P = .02) INTERPRETATION: Multimodal telemonitoring 
      may enhance BW reduction efforts in patients with OSA and obesity. TRIAL 
      REGISTRY: UMIN Clinical Trials Registry; No.: UMIN000033607; URL: 
      www.umin.ac.jp/ctr/index.htm.
CI  - Copyright (c) 2022 American College of Chest Physicians. Published by Elsevier Inc. 
      All rights reserved.
FAU - Murase, Kimihiko
AU  - Murase K
AD  - Department of Respiratory Care and Sleep Control Medicine.
FAU - Minami, Takuma
AU  - Minami T
AD  - Department of Respiratory Medicine; Department of Primary Care and Emergency 
      Medicine.
FAU - Hamada, Satoshi
AU  - Hamada S
AD  - Department of Advanced Medicine for Respiratory Failure.
FAU - Gozal, David
AU  - Gozal D
AD  - Department of Child Health and Child Health Research Institute, University of 
      Missouri, Columbia, MO.
FAU - Takahashi, Naomi
AU  - Takahashi N
AD  - Department of Respiratory Care and Sleep Control Medicine.
FAU - Nakatsuka, Yoshinari
AU  - Nakatsuka Y
AD  - Department of Respiratory Care and Sleep Control Medicine.
FAU - Takeyama, Hirofumi
AU  - Takeyama H
AD  - Department of Respiratory Care and Sleep Control Medicine.
FAU - Tanizawa, Kiminobu
AU  - Tanizawa K
AD  - Department of Respiratory Medicine.
FAU - Endo, Daisuke
AU  - Endo D
AD  - Shinjuku Sleep and Respiratory Clinic.
FAU - Akahoshi, Toshiki
AU  - Akahoshi T
AD  - Shinjuku Sleep and Respiratory Clinic.
FAU - Moritsuchi, Yasutaka
AU  - Moritsuchi Y
AD  - Center, Kirigaoka Tsuda Hospital, Kitakyusyu.
FAU - Tsuda, Toru
AU  - Tsuda T
AD  - Center, Kirigaoka Tsuda Hospital, Kitakyusyu.
FAU - Toyama, Yoshiro
AU  - Toyama Y
AD  - Sleep Medical Center, Osaka Kaisei Hospital, Osaka.
FAU - Ohi, Motoharu
AU  - Ohi M
AD  - Sleep Medical Center, Osaka Kaisei Hospital, Osaka.
FAU - Tomita, Yasuhiro
AU  - Tomita Y
AD  - Sleep Center, Toranomon Hospital.
FAU - Narui, Koji
AU  - Narui K
AD  - Sleep Center, Toranomon Hospital.
FAU - Matsuyama, Naho
AU  - Matsuyama N
AD  - Department of Respiratory Medicine, National Hospital Organization Nishiniigata 
      Chuo Hospital, Niigata.
FAU - Ohdaira, Tetsuro
AU  - Ohdaira T
AD  - Department of Respiratory Medicine, National Hospital Organization Nishiniigata 
      Chuo Hospital, Niigata.
FAU - Kasai, Takatoshi
AU  - Kasai T
AD  - Department of Cardiovascular Biology and Medicine, Juntendo University Graduate 
      School of Medicine.
FAU - Tsuboi, Tomomasa
AU  - Tsuboi T
AD  - Center of Respiratory Medicine, National Hospital Organization Minami Kyoto 
      Hospital, Joyo.
FAU - Gon, Yasuhiro
AU  - Gon Y
AD  - Division of Respiratory Medicine, Department of Internal Medicine.
FAU - Yamashiro, Yoshihiro
AU  - Yamashiro Y
AD  - Ureshinogaoka Samaritan Hospital, Okinawa.
FAU - Ando, Shinichi
AU  - Ando S
AD  - Sleep Apnea Center, Kyushu University Hospital, Fukuoka.
FAU - Yoshimine, Hiroyuki
AU  - Yoshimine H
AD  - Shunkaikai Inoue Hospital, Nagasaki.
FAU - Takata, Yoshifumi
AU  - Takata Y
AD  - Department of Cardiology, Tokyo Medical University, Tokyo.
FAU - Yoshihisa, Akiomi
AU  - Yoshihisa A
AD  - Department of Cardiovascular Medicine; Department of Clinical Laboratory 
      Sciences, Fukushima Medical University School of Health Science, Fukushima.
FAU - Tatsumi, Koichiro
AU  - Tatsumi K
AD  - Department of Respirology, Graduate School of Medicine, Chiba University, Chiba.
FAU - Momomura, Shin-Ichi
AU  - Momomura SI
AD  - Saitama Citizens Medical Center, Saitama, Japan.
FAU - Kuroda, Tomohiro
AU  - Kuroda T
AD  - Division of Medical Information Technology and Administration Planning, Kyoto 
      University Hospital, Kyoto.
FAU - Morita, Satoshi
AU  - Morita S
AD  - Department of Biomedical Statistics and Bioinformatics.
FAU - Nakayama, Takeo
AU  - Nakayama T
AD  - Department of Health Informatics, School of Public Health, Kyoto University 
      Graduate School of Medicine.
FAU - Hirai, Toyohiro
AU  - Hirai T
AD  - Department of Respiratory Medicine.
FAU - Chin, Kazuo
AU  - Chin K
AD  - Department of Respiratory Care and Sleep Control Medicine; Center for Genomic 
      Medicine; Department of Sleep Medicine and Respiratory Care, Division of Sleep 
      Medicine, Department of Internal Medicine, Nihon University School of Medicine. 
      Electronic address: chink@kuhp.kyoto-u.ac.jp.
LA  - eng
PT  - Journal Article
PT  - Randomized Controlled Trial
DEP - 20220823
PL  - United States
TA  - Chest
JT  - Chest
JID - 0231335
SB  - IM
MH  - Humans
MH  - Continuous Positive Airway Pressure
MH  - *Sleep Apnea, Obstructive/therapy
MH  - *Sleep Apnea Syndromes
MH  - Weight Loss
MH  - Obesity/therapy
OTO - NOTNLM
OT  - body weight reduction
OT  - obesity
OT  - sleep apnea
OT  - telemedicine
OT  - weight loss
EDAT- 2022/08/24 06:00
MHDA- 2022/12/15 06:00
CRDT- 2022/08/23 19:23
PHST- 2022/01/24 00:00 [received]
PHST- 2022/07/11 00:00 [revised]
PHST- 2022/07/27 00:00 [accepted]
PHST- 2022/08/24 06:00 [pubmed]
PHST- 2022/12/15 06:00 [medline]
PHST- 2022/08/23 19:23 [entrez]
AID - S0012-3692(22)03651-0 [pii]
AID - 10.1016/j.chest.2022.07.032 [doi]
PST - ppublish
SO  - Chest. 2022 Dec;162(6):1373-1383. doi: 10.1016/j.chest.2022.07.032. Epub 2022 Aug 
      23.