PMID- 35998836
OWN - NLM
STAT- MEDLINE
DCOM- 20221026
LR  - 20221026
IS  - 1532-2939 (Electronic)
IS  - 0195-6701 (Linking)
VI  - 129
DP  - 2022 Nov
TI  - Practice testing of generic quality indicators for responsible antibiotic use in 
      nine hospitals in the Dutch-Belgian border area.
PG  - 153-161
LID - S0195-6701(22)00252-3 [pii]
LID - 10.1016/j.jhin.2022.07.030 [doi]
AB  - BACKGROUND: Inpatient quality indicators (IQIs) were previously developed to 
      assess responsible antibiotic use. AIM: Practice testing of these QIs in the 
      hospital setting. METHOD: This study was performed within a Dutch-Belgian border 
      network of hospitals implementing the Infection Risk Scan (IRIS) point prevalence 
      survey (PPS) as part of the i-4-1-Health project. Twenty out of 51 DRIVE-AB IQIs, 
      including 13 structure and seven process IQIs, were tested. Data on structure 
      IQIs were obtained through a web-based questionnaire sent to the hospital medical 
      microbiologists. PPS data from October to December 2018 were used to calculate 
      performance scores for the process QIs. FINDINGS: Nine hospitals participated. 
      Regarding structure IQIs: the lowest performance scores were observed for 
      recommendations for microbiological investigations in the guidelines and the use 
      of an approval system for restricted antibiotics. In addition, most hospitals 
      reported that some antibiotics were out of stock due to shortages. Regarding 
      process IQIs: 697 systemic antibiotic prescriptions were used to calculate 
      performance scores. The lowest score was observed for documentation of an 
      antibiotic plan in the medical file (58.8%). Performance scores for IQIs on 
      guideline compliance varied between 74.1% and 82.3% for different aspects of the 
      antibiotic regimen (duration, choice, route, timing). CONCLUSION: This 
      multicentre practice testing of IQIs identified improvement targets for 
      stewardship efforts for both structure and process aspects of antibiotic care 
      (approval system for restricted antibiotics, documentation of antibiotic plan). 
      These results can guide the design of future PPS studies and a more extensive 
      evaluation of the clinimetric properties of the IQIs.
CI  - Copyright (c) 2022 The Author(s). Published by Elsevier Ltd.. All rights reserved.
FAU - Monnier, A A
AU  - Monnier AA
AD  - Faculty of Medicine and Life Sciences, Hasselt University, Hasselt, Belgium; 
      Department of Internal Medicine, and Radboudumc Center for Infectious Diseases, 
      Radboud University Medical Center, Nijmegen, The Netherlands. Electronic address: 
      annelie.monnier@radboudumc.nl.
FAU - D'Onofrio, V
AU  - D'Onofrio V
AD  - Faculty of Medicine and Life Sciences, Hasselt University, Hasselt, Belgium; 
      Department of Internal Medicine, and Radboudumc Center for Infectious Diseases, 
      Radboud University Medical Center, Nijmegen, The Netherlands.
FAU - Willemsen, I
AU  - Willemsen I
AD  - Department of Infection Control, Amphia Hospital, Breda, The Netherlands; 
      Contrain Infectiepreventiecoach, Breda, The Netherlands.
FAU - Kluytmans-van den Bergh, M F Q
AU  - Kluytmans-van den Bergh MFQ
AD  - Department of Infection Control, Amphia Hospital, Breda, The Netherlands; Amphia 
      Academy Infectious Disease Foundation, Amphia Hospital Breda, The Netherlands; 
      Julius Center for Health Sciences and Primary Care, UMC Utrecht, Utrecht, The 
      Netherlands.
FAU - Kluytmans, J A J W
AU  - Kluytmans JAJW
AD  - Department of Infection Control, Amphia Hospital, Breda, The Netherlands; Julius 
      Center for Health Sciences and Primary Care, UMC Utrecht, Utrecht, The 
      Netherlands; Microvida Laboratory for Medical Microbiology, Amphia Hospital, 
      Breda, The Netherlands.
FAU - Schuermans, A
AU  - Schuermans A
AD  - Department of Infection Control and Epidemiology, University Hospitals Leuven, 
      Katholieke Universiteit Leuven, Leuven, Belgium.
FAU - Leroux-Roels, I
AU  - Leroux-Roels I
AD  - Ghent University and Ghent University Hospital, Ghent, Belgium.
FAU - Gyssens, I C
AU  - Gyssens IC
AD  - Faculty of Medicine and Life Sciences, Hasselt University, Hasselt, Belgium; 
      Department of Internal Medicine, and Radboudumc Center for Infectious Diseases, 
      Radboud University Medical Center, Nijmegen, The Netherlands.
CN  - i-4-1 Health Study Group
LA  - eng
PT  - Journal Article
DEP - 20220820
PL  - England
TA  - J Hosp Infect
JT  - The Journal of hospital infection
JID - 8007166
RN  - 0 (Anti-Bacterial Agents)
SB  - IM
MH  - Humans
MH  - *Anti-Bacterial Agents/therapeutic use
MH  - *Quality Indicators, Health Care
MH  - Belgium
MH  - Hospitals
MH  - Inpatients
OTO - NOTNLM
OT  - Antibiotic shortages
OT  - Antibiotic use
OT  - Antimicrobial stewardship
OT  - Point-prevalence survey
OT  - Quality indicator
EDAT- 2022/08/24 06:00
MHDA- 2022/10/27 06:00
CRDT- 2022/08/23 19:26
PHST- 2022/05/23 00:00 [received]
PHST- 2022/07/29 00:00 [revised]
PHST- 2022/07/30 00:00 [accepted]
PHST- 2022/08/24 06:00 [pubmed]
PHST- 2022/10/27 06:00 [medline]
PHST- 2022/08/23 19:26 [entrez]
AID - S0195-6701(22)00252-3 [pii]
AID - 10.1016/j.jhin.2022.07.030 [doi]
PST - ppublish
SO  - J Hosp Infect. 2022 Nov;129:153-161. doi: 10.1016/j.jhin.2022.07.030. Epub 2022 
      Aug 20.