PMID- 35999431
OWN - NLM
STAT- MEDLINE
DCOM- 20221011
LR  - 20221011
IS  - 1573-2649 (Electronic)
IS  - 0962-9343 (Linking)
VI  - 31
IP  - 11
DP  - 2022 Nov
TI  - Establishing the minimal clinically important difference of the EQ-5D-3L in older 
      adults with a history of falls.
PG  - 3293-3303
LID - 10.1007/s11136-022-03231-x [doi]
AB  - PURPOSE: Establish the minimal clinically important difference (MCID) of a 
      health-related quality of life (HRQoL) measure-the EuroQol EQ-5 Dimensions-3 
      Level (EQ-5D-3L)-in older adults with a history of falls. METHODS: This study is 
      a secondary analysis of 255 complete cases who were enrolled in a 12-month 
      randomized controlled trial (NCT01029171; NCT00323596); participants were 
      randomized to the Otago Exercise Program (OEP; n = 126/172; Age:81.2 +/- 6.2 years; 
      60.3% Female) or control (CON; n = 129/172; Age:81.7 +/- 5.7 years; 70.5% Female). 
      Participants completed the EQ-5D-3L and Visual Analogue Scale (VAS) at baseline 
      and 1-year. The VAS was associated with HRQoL and was the health status anchor 
      (VAS minimal improvement = 7 to 17, maximal improvement >/= 18, minimal 
      decline =  - 7 to - 17, maximal decline </=  - 18 points). We used four distinct 
      approaches to estimate MCID ranges: (1) anchor-based change differences of the 
      EQ-5D-3L (1-year minus baseline); (2) anchor-based beta coefficients from 
      ordinary least squares regressions (OLS); (3) anchor-based receiver operating 
      characteristic (ROC), and 4) distribution-based standard deviation and 
      standardized effect size of 0.5. RESULTS: EQ-5D-3L MCID ranges for minimal 
      improvements (OEP = 0.028 to 0.059; CON = 0.007 to 0.051), maximal improvements 
      (OEP = 0.059 to 0.090; CON = 0.051 to 0.090), minimal declines (OEP =  - 0.029 
      to - 0.105; CON =  - 0.015 to - 0.051), and maximal declines (OEP =  - 0.018 
      to - 0.072; CON =  - 0.018 to - 0.082) were established using change difference, 
      OLS, and distribution-based methods. The ROC area under the curve was poor, thus, 
      it was not used to estimate the MCID. CONCLUSIONS: Our results will assist in the 
      interpretation of changes in HRQoL, as measured by the EQ-5D-3L, in older adults 
      with a history of falls.
CI  - (c) 2022. The Author(s), under exclusive licence to Springer Nature Switzerland AG.
FAU - Jehu, Deborah A
AU  - Jehu DA
AD  - Interdisciplinary Health Sciences Department, College of Allied Health Sciences, 
      Augusta University, Augusta, GA, USA.
AD  - Centre for Hip Health and Mobility, Vancouver Coastal Health Research Institute, 
      Vancouver, BC, Canada.
AD  - Djavad Mowafaghian Centre for Brain Health, Vancouver Coastal Health Research 
      Institute, Vancouver, BC, Canada.
AD  - Aging, Mobility and Cognitive Neuroscience Laboratory, Department of Physical 
      Therapy, Faculty of Medicine, University of British Columbia, 2329 West Mall, 
      Vancouver, BC, V6T 1Z4, Canada.
FAU - Davis, Jennifer C
AU  - Davis JC
AD  - Centre for Hip Health and Mobility, Vancouver Coastal Health Research Institute, 
      Vancouver, BC, Canada.
AD  - Djavad Mowafaghian Centre for Brain Health, Vancouver Coastal Health Research 
      Institute, Vancouver, BC, Canada.
AD  - Social & Economic Change Laboratory, Faculty of Management, University of British 
      Columbia-Okanagan Campus, Kelowna, BC, Canada.
AD  - Applied Health Economics Laboratory, The University of British Columbia - 
      Okanagan, Kelowna, Canada.
FAU - Madden, Kenneth
AU  - Madden K
AD  - Centre for Hip Health and Mobility, Vancouver Coastal Health Research Institute, 
      Vancouver, BC, Canada.
AD  - Gerontology and Diabetes Research Laboratory, Division of Geriatric Medicine, 
      Department of Medicine, Faculty of Medicine, University of British Columbia, 
      Vancouver, BC, Canada.
FAU - Parmar, Naaz
AU  - Parmar N
AD  - Division of Geriatric Medicine, Department of Medicine, Faculty of Medicine, 
      University of British Columbia, Vancouver, BC, Canada.
FAU - Liu-Ambrose, Teresa
AU  - Liu-Ambrose T
AUID- ORCID: 0000-0003-1016-196X
AD  - Centre for Hip Health and Mobility, Vancouver Coastal Health Research Institute, 
      Vancouver, BC, Canada. teresa.ambrose@ubc.ca.
AD  - Djavad Mowafaghian Centre for Brain Health, Vancouver Coastal Health Research 
      Institute, Vancouver, BC, Canada. teresa.ambrose@ubc.ca.
AD  - Aging, Mobility and Cognitive Neuroscience Laboratory, Department of Physical 
      Therapy, Faculty of Medicine, University of British Columbia, 2329 West Mall, 
      Vancouver, BC, V6T 1Z4, Canada. teresa.ambrose@ubc.ca.
LA  - eng
GR  - MOP-110954/CAPMC/CIHR/Canada
GR  - MAT-92025/CAPMC/CIHR/Canada
GR  - MOP-110954/CAPMC/CIHR/Canada
GR  - MAT-92025/CAPMC/CIHR/Canada
PT  - Journal Article
PT  - Randomized Controlled Trial
DEP - 20220823
PL  - Netherlands
TA  - Qual Life Res
JT  - Quality of life research : an international journal of quality of life aspects of 
      treatment, care and rehabilitation
JID - 9210257
SB  - IM
MH  - Aged
MH  - Aged, 80 and over
MH  - Female
MH  - Health Status
MH  - Humans
MH  - Male
MH  - *Minimal Clinically Important Difference
MH  - Pain Measurement/methods
MH  - *Quality of Life/psychology
MH  - Surveys and Questionnaires
MH  - Visual Analog Scale
OTO - NOTNLM
OT  - Accidental falls
OT  - Minimal clinically important difference
OT  - Older adults
OT  - Psychometrics
OT  - Quality of life
EDAT- 2022/08/24 06:00
MHDA- 2022/10/12 06:00
CRDT- 2022/08/23 23:28
PHST- 2022/08/04 00:00 [accepted]
PHST- 2022/08/24 06:00 [pubmed]
PHST- 2022/10/12 06:00 [medline]
PHST- 2022/08/23 23:28 [entrez]
AID - 10.1007/s11136-022-03231-x [pii]
AID - 10.1007/s11136-022-03231-x [doi]
PST - ppublish
SO  - Qual Life Res. 2022 Nov;31(11):3293-3303. doi: 10.1007/s11136-022-03231-x. Epub 
      2022 Aug 23.