PMID- 35999465
OWN - NLM
STAT- MEDLINE
DCOM- 20230405
LR  - 20230405
IS  - 1432-5241 (Electronic)
IS  - 0364-216X (Linking)
VI  - 47
IP  - 2
DP  - 2023 Apr
TI  - Health Utility Measures Among Patients with Androgenetic Alopecia After Hair 
      Transplant.
PG  - 631-639
LID - 10.1007/s00266-022-03066-4 [doi]
AB  - BACKGROUND: Hair loss causes significant psychosocial distress to patients. 
      Health utility measurements offer an objective, quantitative assessment of 
      health-related quality of life (QOL). METHODS: We performed a prospective cohort 
      study on patients with hair loss between January 1, 2018 and December 31, 2020. 
      Patient metrics were compared with layperson perception of alopecia, 
      prospectively collected between August 1 and December 31, 2017. Health utility 
      measures were quantified using the visual analog scale (VAS), standard gamble 
      (SG), and time trade-off (TTO) in quality-adjusted life-years (QALYs) and 
      relative to the minimal clinically important difference (MCID). Bonferroni 
      correction to the significance threshold was performed. RESULTS: Thirty-one 
      patients with alopecia were compared with 237 laypeople. Patient metrics for 
      female hair loss were all significantly lower than laypeople measures (VAS QALYs 
      0.65 +/- 0.21 vs. 0.83 +/- 0.18, p = 0.0001). Mean SG QALYs were lower for patients 
      in the male alopecia state (0.86 +/- 0.23 vs. 0.96 +/- 0.12, p = 0.0278). Post-hair 
      transplant improvement in TTO was significantly greater for patients (+ 
      0.08 +/- 0.12 vs. + 0.02 +/- 0.09, p = 0.0070) and significantly more often exceeded 
      the MCID (45.2% vs. 16.9%, p = 0.0006). CONCLUSIONS: Alopecia negatively impacts 
      QOL, and the true patient experience is more taxing than what is perceived by 
      laypeople. Hair transplantation improves QOL more for male patients than common 
      perception. LEVEL OF EVIDENCE IV: This journal requires that authors assign a 
      level of evidence to each article. For a full description of these Evidence-Based 
      Medicine ratings, please refer to the Table of Contents or the online 
      Instructions to Authors www.springer.com/00266 .
CI  - (c) 2022. Springer Science+Business Media, LLC, part of Springer Nature and 
      International Society of Aesthetic Plastic Surgery.
FAU - Xiao, Roy
AU  - Xiao R
AUID- ORCID: 0000-0003-4459-0746
AD  - Department of Otolaryngology, Massachusetts Eye and Ear, Boston, MA, USA.
AD  - Department of Otolaryngology, Harvard Medical School, Boston, MA, USA.
FAU - Burks, Ciersten A
AU  - Burks CA
AD  - Department of Otolaryngology, Massachusetts Eye and Ear, Boston, MA, USA.
AD  - Department of Otolaryngology, Harvard Medical School, Boston, MA, USA.
FAU - Yau, Jenny
AU  - Yau J
AD  - Department of Otolaryngology, Massachusetts Eye and Ear, Boston, MA, USA.
FAU - Derakhshan, Adeeb
AU  - Derakhshan A
AD  - Department of Otolaryngology, Massachusetts Eye and Ear, Boston, MA, USA.
AD  - Department of Otolaryngology, Harvard Medical School, Boston, MA, USA.
FAU - Liu, Rui Han
AU  - Liu RH
AD  - Department of Otolaryngology, Massachusetts Eye and Ear, Boston, MA, USA.
AD  - Department of Otolaryngology, Harvard Medical School, Boston, MA, USA.
FAU - Senna, Maryanne M
AU  - Senna MM
AD  - Department of Dermatology, Lahey Hospital & Medical Center, Boston, MA, USA.
AD  - Lahey Hair Loss Center of Excellence and Research Unit, Boston, MA, USA.
FAU - Yasuda, Mariko R
AU  - Yasuda MR
AD  - Department of Dermatology, Massachusetts General Hospital, Boston, MA, USA.
FAU - Jowett, Nate
AU  - Jowett N
AD  - Department of Otolaryngology, Massachusetts Eye and Ear, Boston, MA, USA.
AD  - Department of Otolaryngology, Harvard Medical School, Boston, MA, USA.
AD  - Division of Facial Plastic and Reconstructive Surgery, Department of 
      Otolaryngology - Head and Neck Surgery, Massachusetts Eye and Ear, 243 Charles 
      Street, Boston, MA, 02114, USA.
FAU - Lee, Linda N
AU  - Lee LN
AD  - Department of Otolaryngology, Massachusetts Eye and Ear, Boston, MA, USA. 
      linda_lee@meei.harvard.edu.
AD  - Department of Otolaryngology, Harvard Medical School, Boston, MA, USA. 
      linda_lee@meei.harvard.edu.
AD  - Division of Facial Plastic and Reconstructive Surgery, Department of 
      Otolaryngology - Head and Neck Surgery, Massachusetts Eye and Ear, 243 Charles 
      Street, Boston, MA, 02114, USA. linda_lee@meei.harvard.edu.
LA  - eng
PT  - Journal Article
DEP - 20220823
PL  - United States
TA  - Aesthetic Plast Surg
JT  - Aesthetic plastic surgery
JID - 7701756
SB  - IM
MH  - Humans
MH  - Male
MH  - Female
MH  - *Quality of Life
MH  - Prospective Studies
MH  - *Alopecia/diagnosis/surgery
MH  - Hair
MH  - Quality-Adjusted Life Years
OTO - NOTNLM
OT  - Alopecia
OT  - Hair loss
OT  - Hair transplant
OT  - Health state utility
OT  - Quality of life
EDAT- 2022/08/24 06:00
MHDA- 2023/04/05 06:42
CRDT- 2022/08/23 23:30
PHST- 2022/07/05 00:00 [received]
PHST- 2022/08/08 00:00 [accepted]
PHST- 2023/04/05 06:42 [medline]
PHST- 2022/08/24 06:00 [pubmed]
PHST- 2022/08/23 23:30 [entrez]
AID - 10.1007/s00266-022-03066-4 [pii]
AID - 10.1007/s00266-022-03066-4 [doi]
PST - ppublish
SO  - Aesthetic Plast Surg. 2023 Apr;47(2):631-639. doi: 10.1007/s00266-022-03066-4. 
      Epub 2022 Aug 23.