PMID- 36001505
OWN - NLM
STAT- MEDLINE
DCOM- 20221007
LR  - 20221011
IS  - 1097-0231 (Electronic)
IS  - 0951-4198 (Linking)
VI  - 36
IP  - 22
DP  - 2022 Nov 30
TI  - A fast gas chromatography coupled with electron capture negative ion mass 
      spectrometry in selected ion monitoring mode screening method for short-chain and 
      medium-chain chlorinated paraffins.
PG  - e9382
LID - 10.1002/rcm.9382 [doi]
AB  - RATIONALE: Chlorinated paraffins (CPs) are a group of anthropogenic pollutants 
      that consist of complex mixtures of polychlorinated n-alkanes of different chain 
      lengths (~C(10) to C(30) ). Persistence, bioaccumulation, toxicity, and 
      long-range transport of short-chain chlorinated paraffins (SCCPs, C(10) - to 
      C(13) -CPs) have prompted their classification as persistent organic pollutants 
      (POPs) by the Stockholm Convention in 2017. Due to the varying chain lengths and 
      chlorination degrees, quantification of SCCPs and medium-chain chlorinated 
      paraffins (MCCPs, C(14) - to C(17) ) using gas chromatography coupled with 
      electron capture negative ion mass spectrometry in selected ion monitoring mode 
      (GC/ECNI-MS-SIM) is not only challenging but also very time consuming. In 
      particular, up to eight GC runs per sample are required for the comprehensive 
      GC/ECNI-MS-SIM quantification of SCCPs and MCCPs. These efforts are high 
      especially if the samples do not contain CPs above the limit of detection (LOD), 
      subsequently. METHODS: We developed a semi-quantitative and sensitive method for 
      the examination of SCCPs and MCCPs in one GC run. This GC/ECNI-MS-SIM screening 
      method was based on the recording of Cl(-) (m/z 35 and 37), Cl(2) (-) (m/z 70 and 
      72), and HCl(2) (-) (m/z 71 and 73) isotope ions and evaluation of the ratios 
      between them. RESULTS: Correctness of the results of the screening method was 
      verified by analysis of edible oils with and without CPs, CP standards, as well 
      as a technical CP mixture. Polychlorinated biphenyls (PCBs) and other 
      polyhalogenated aromatic compounds, as well as brominated flame retardants, do 
      not form all of the fragment ions analyzed by the screening method. CONCLUSIONS: 
      After the screening, only CP-positive samples may need to be measured in detail. 
      Measurement time will already be gained in the case of ~10% samples without CPs.
CI  - (c) 2022 The Authors. Rapid Communications in Mass Spectrometry published by John 
      Wiley & Sons Ltd.
FAU - Schweizer, Sina
AU  - Schweizer S
AUID- ORCID: 0000-0001-6753-219X
AD  - Department of Food Chemistry (170b), University of Hohenheim, Institute of Food 
      Chemistry, Stuttgart, Germany.
FAU - Schulz, Tobias
AU  - Schulz T
AD  - Department of Food Chemistry (170b), University of Hohenheim, Institute of Food 
      Chemistry, Stuttgart, Germany.
FAU - Vetter, Walter
AU  - Vetter W
AD  - Department of Food Chemistry (170b), University of Hohenheim, Institute of Food 
      Chemistry, Stuttgart, Germany.
LA  - eng
PT  - Journal Article
PL  - England
TA  - Rapid Commun Mass Spectrom
JT  - Rapid communications in mass spectrometry : RCM
JID - 8802365
RN  - 0 (Alkanes)
RN  - 0 (Complex Mixtures)
RN  - 0 (Environmental Pollutants)
RN  - 0 (Flame Retardants)
RN  - 0 (Hydrocarbons, Chlorinated)
RN  - 0 (Ions)
RN  - 0 (Oils)
RN  - 8002-74-2 (Paraffin)
RN  - DFC2HB4I0K (Polychlorinated Biphenyls)
SB  - IM
MH  - Alkanes/analysis
MH  - Complex Mixtures/analysis
MH  - Electrons
MH  - Environmental Monitoring/methods
MH  - *Environmental Pollutants/analysis
MH  - *Flame Retardants/analysis
MH  - Gas Chromatography-Mass Spectrometry/methods
MH  - *Hydrocarbons, Chlorinated/analysis/chemistry
MH  - Ions/analysis
MH  - Mass Spectrometry
MH  - Oils
MH  - Paraffin/analysis/chemistry
MH  - Persistent Organic Pollutants
MH  - *Polychlorinated Biphenyls/analysis
EDAT- 2022/08/25 06:00
MHDA- 2022/10/12 06:00
CRDT- 2022/08/24 13:23
PHST- 2022/08/19 00:00 [revised]
PHST- 2022/07/07 00:00 [received]
PHST- 2022/08/22 00:00 [accepted]
PHST- 2022/08/25 06:00 [pubmed]
PHST- 2022/10/12 06:00 [medline]
PHST- 2022/08/24 13:23 [entrez]
AID - 10.1002/rcm.9382 [doi]
PST - ppublish
SO  - Rapid Commun Mass Spectrom. 2022 Nov 30;36(22):e9382. doi: 10.1002/rcm.9382.