PMID- 36001730
OWN - NLM
STAT- MEDLINE
DCOM- 20221026
LR  - 20230825
IS  - 1365-2249 (Electronic)
IS  - 0009-9104 (Print)
IS  - 0009-9104 (Linking)
VI  - 210
IP  - 1
DP  - 2022 Oct 21
TI  - Upregulated expression of substance P and NK1R in blood monocytes and B cells of 
      patients with allergic rhinitis and asthma.
PG  - 39-52
LID - 10.1093/cei/uxac074 [doi]
AB  - Increased expression of substance P (SP) and neurokinin-1 receptor (NK1R) has 
      been noticed in patients with allergic rhinitis (AR) and allergic asthma (AA). 
      However, little is known of the expression of SP and NK1R in monocytes and B 
      cells of AR and AA. In the present study, the expression levels of SP and NK1R 
      were determined by flow cytometry and mouse AR and AA models. The results showed 
      that both percentages of SP+ monocytes and SP+ B cells, and mean fluorescence 
      intensity (MFI) of SP in monocytes were elevated in the blood of AA and AR 
      combined with AA (ARA) patients. Similarly, the percentages of NK1R+ monocytes 
      were elevated in the blood of AR, AA, and ARA patients. Allergens Artemisia 
      sieversiana wild allergen extract (ASWE), house dust mite extract (HDME), and 
      Platanus pollen allergen extract (PPE) increased the expression density of SP 
      molecules (determined by MFI) in an individual monocyte of AR patients. HDME and 
      PPE appeared to enhance SP and NK1R expression in the B cells of ARA and AR 
      patients. In the mouse AR and AA models, the percentages of NK1R+ monocytes and B 
      cells were elevated in blood following OVA (ovalbumin) sensitization and 
      challenge. Knocking out the FcepsilonRI molecule completely abolished the OVA-induced 
      upregulation of expression of NK1R in monocytes and B cells of AA mice. In 
      conclusion, upregulated expressions of SP and NK1R may contribute to the 
      pathogenesis of airway allergy.
CI  - (c) The Author(s) 2022. Published by Oxford University Press on behalf of the 
      British Society for Immunology.
FAU - Han, Peixuan
AU  - Han P
AD  - Department of Pathophysiology, Translational Medicine Institute, Shenyang Medical 
      College, Shenyang, Liaoning, China.
FAU - Chen, Liping
AU  - Chen L
AD  - Department of Respiratory Medicine, The Second Affiliated Hospital of Shenyang 
      Medical College, Shenyang, Liaoning, China.
FAU - Chen, Dong
AU  - Chen D
AD  - Allergy and Clinical Immunology Research Centre, The First Affiliated Hospital of 
      Jinzhou Medical University, Jinzhou, Liaoning, China.
FAU - Yang, Ruiming
AU  - Yang R
AD  - Allergy and Clinical Immunology Research Centre, The First Affiliated Hospital of 
      Jinzhou Medical University, Jinzhou, Liaoning, China.
FAU - Wang, Wei
AU  - Wang W
AD  - Allergy and Clinical Immunology Research Centre, The First Affiliated Hospital of 
      Jinzhou Medical University, Jinzhou, Liaoning, China.
FAU - Liu, Jingyu
AU  - Liu J
AD  - Allergy and Clinical Immunology Research Centre, The First Affiliated Hospital of 
      Jinzhou Medical University, Jinzhou, Liaoning, China.
FAU - He, Shaoheng
AU  - He S
AD  - Department of Pathophysiology, Translational Medicine Institute, Shenyang Medical 
      College, Shenyang, Liaoning, China.
AD  - Allergy and Clinical Immunology Research Centre, The First Affiliated Hospital of 
      Jinzhou Medical University, Jinzhou, Liaoning, China.
FAU - Zhang, Huiyun
AU  - Zhang H
AUID- ORCID: 0000-0003-0631-3000
AD  - Department of Pathophysiology, Translational Medicine Institute, Shenyang Medical 
      College, Shenyang, Liaoning, China.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Clin Exp Immunol
JT  - Clinical and experimental immunology
JID - 0057202
RN  - 0 (Allergens)
RN  - 9006-59-1 (Ovalbumin)
RN  - 0 (Receptors, Neurokinin-1)
RN  - 33507-63-0 (Substance P)
RN  - 0 (TACR1 protein, human)
SB  - IM
MH  - Animals
MH  - Mice
MH  - Allergens
MH  - *Asthma
MH  - Monocytes/metabolism
MH  - Ovalbumin
MH  - Receptors, Neurokinin-1/genetics/metabolism
MH  - *Rhinitis, Allergic
MH  - Substance P/metabolism/pharmacology
PMC - PMC9585549
OTO - NOTNLM
OT  - B cell
OT  - NK1R
OT  - allergic asthma
OT  - allergic rhinitis
OT  - monocyte
OT  - substance P
EDAT- 2022/08/25 06:00
MHDA- 2022/10/25 06:00
PMCR- 2023/08/24
CRDT- 2022/08/24 14:13
PHST- 2022/01/03 00:00 [received]
PHST- 2022/07/21 00:00 [revised]
PHST- 2022/08/15 00:00 [accepted]
PHST- 2022/08/25 06:00 [pubmed]
PHST- 2022/10/25 06:00 [medline]
PHST- 2022/08/24 14:13 [entrez]
PHST- 2023/08/24 00:00 [pmc-release]
AID - 6674696 [pii]
AID - uxac074 [pii]
AID - 10.1093/cei/uxac074 [doi]
PST - ppublish
SO  - Clin Exp Immunol. 2022 Oct 21;210(1):39-52. doi: 10.1093/cei/uxac074.