PMID- 36001975
OWN - NLM
STAT- MEDLINE
DCOM- 20220826
LR  - 20221013
IS  - 2211-1247 (Electronic)
VI  - 40
IP  - 8
DP  - 2022 Aug 23
TI  - The Bruce effect: Representational stability and memory formation in the 
      accessory olfactory bulb of the female mouse.
PG  - 111262
LID - S2211-1247(22)01080-4 [pii]
LID - 10.1016/j.celrep.2022.111262 [doi]
AB  - In the Bruce effect, a mated female mouse becomes resistant to the 
      pregnancy-blocking effect of the stud. Various lines of evidence suggest that 
      this form of behavioral imprinting results from reduced sensitivity of the 
      female's accessory olfactory bulb (AOB) to the stud's chemosignals. However, the 
      AOB's combinatorial code implies that diminishing responses to one individual 
      will distort representations of other stimuli. Here, we record extracellular 
      responses of AOB neurons in mated and unmated female mice while presenting urine 
      stimuli from the stud and from other sources. We find that, while initial sensory 
      responses in the AOB (within a timescale required to guide social interactions) 
      remain stable, responses to extended stimulation (as required for eliciting the 
      pregnancy block) display selective attenuation of stud-responsive neurons. Such 
      temporal disassociation could allow attenuation of slow-acting endocrine 
      processes in a stimulus-specific manner without compromising ongoing 
      representations that guide behavior.
CI  - Copyright (c) 2022 The Author(s). Published by Elsevier Inc. All rights reserved.
FAU - Yoles-Frenkel, Michal
AU  - Yoles-Frenkel M
AD  - Department of Medical Neurobiology, Hebrew University Medical School, Faculty of 
      Medicine, Institute for Medical Research Israel Canada, the Hebrew University, 
      Jerusalem 91120, Israel.
FAU - Shea, Stephen D
AU  - Shea SD
AD  - Cold Spring Harbor Laboratory, Cold Spring Harbor, NY 11724, USA.
FAU - Davison, Ian G
AU  - Davison IG
AD  - Department of Biology, Boston University, Boston, MA 02215, USA.
FAU - Ben-Shaul, Yoram
AU  - Ben-Shaul Y
AD  - Department of Medical Neurobiology, Hebrew University Medical School, Faculty of 
      Medicine, Institute for Medical Research Israel Canada, the Hebrew University, 
      Jerusalem 91120, Israel. Electronic address: yoramb@ekmd.huji.ac.il.
LA  - eng
GR  - R01 DC017234/DC/NIDCD NIH HHS/United States
GR  - R01 MH119250/MH/NIMH NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Cell Rep
JT  - Cell reports
JID - 101573691
SB  - IM
MH  - Animals
MH  - Female
MH  - Mice
MH  - *Neurons/physiology
MH  - *Olfactory Bulb/physiology
MH  - Pregnancy
PMC - PMC9446479
MID - NIHMS1832203
OTO - NOTNLM
OT  - Bruce effect
OT  - CP: Neuroscience
OT  - accessory olfactory bulb
OT  - behavioral imprinting
OT  - chemosensory processing
OT  - vomeronasal system
COIS- Declaration of interests The authors declare no competing interests.
EDAT- 2022/08/25 06:00
MHDA- 2022/08/27 06:00
PMCR- 2022/09/06
CRDT- 2022/08/24 18:23
PHST- 2021/11/29 00:00 [received]
PHST- 2022/06/12 00:00 [revised]
PHST- 2022/08/04 00:00 [accepted]
PHST- 2022/08/24 18:23 [entrez]
PHST- 2022/08/25 06:00 [pubmed]
PHST- 2022/08/27 06:00 [medline]
PHST- 2022/09/06 00:00 [pmc-release]
AID - S2211-1247(22)01080-4 [pii]
AID - 10.1016/j.celrep.2022.111262 [doi]
PST - ppublish
SO  - Cell Rep. 2022 Aug 23;40(8):111262. doi: 10.1016/j.celrep.2022.111262.