PMID- 36002071
OWN - NLM
STAT- MEDLINE
DCOM- 20221130
LR  - 20230129
IS  - 1879-1891 (Electronic)
IS  - 0002-9394 (Linking)
VI  - 244
DP  - 2022 Dec
TI  - Cataract Surgery in Uveitis: Risk Factors, Outcomes, and Complications.
PG  - 117-124
LID - S0002-9394(22)00314-2 [pii]
LID - 10.1016/j.ajo.2022.08.014 [doi]
AB  - PURPOSE: To determine the outcomes of cataract surgery in eyes with uveitis, 
      including the rates of intraoperative and postoperative complications, as well as 
      predictors of visual outcomes. DESIGN: Retrospective observational cohort study. 
      METHODS: Setting: Tertiary public hospital setting in Auckland, New Zealand, 
      between 2008 and 2020. STUDY POPULATION: Patients who underwent cataract surgery 
      following a diagnosis of uveitis.Main observation Procedures: Additional 
      intraoperative procedures, intraoperative and postoperative complications, and 
      postoperative visual outcomes and complications. RESULTS: 471 eyes of 371 
      subjects were included. Median duration of uveitis prior to cataract surgery was 
      3.0 years (interquartile range [IQR] 5.2) and median period of quiescence prior 
      to surgery was 1.0 years (IQR 1.5). Additional procedures (posterior synechiae 
      peel [32.3%] and vision blue [18.1%]) were common. Intraoperative complications 
      occurred in 32 eyes (6.8%). Consultants were the primary surgeons in the majority 
      (82.5%) of operations. By 12 months, visual acuity was 20/50 or better in 248 
      eyes (79.7%). The most common postoperative complication was uveitis flare, 
      occurring in 56.5%. On Cox proportional hazards analysis, time quiescent was 
      associated with reduced risk of flare (HR 0.794, P = .003). Postoperative cystoid 
      macular edema (CME) developed in 45 eyes (9.6%), with no significant predictors 
      identified on multivariate analysis. CONCLUSIONS: Cataract surgery in uveitis is 
      complex. In the hands of the surgically experienced, rates of intraoperative 
      complications are low. The primary challenge is managing postoperative care as we 
      report a high rate of uveitis relapse and CME. Careful monitoring is important as 
      complications can be unpredictable and occur later than expected.
CI  - Copyright (c) 2022 Elsevier Inc. All rights reserved.
FAU - Al-Ani, Haya Husam
AU  - Al-Ani HH
AD  - From the Department of Ophthalmology, Auckland District Health Board, Auckland, 
      New Zealand.
FAU - Sims, Joanne Lesley
AU  - Sims JL
AD  - From the Department of Ophthalmology, Auckland District Health Board, Auckland, 
      New Zealand.
FAU - Niederer, Rachael Louise
AU  - Niederer RL
AD  - From the Department of Ophthalmology, Auckland District Health Board, Auckland, 
      New Zealand. Electronic address: dr_rachnz@yahoo.co.nz.
LA  - eng
PT  - Journal Article
PT  - Observational Study
DEP - 20220821
PL  - United States
TA  - Am J Ophthalmol
JT  - American journal of ophthalmology
JID - 0370500
SB  - IM
MH  - Humans
MH  - *Phacoemulsification/methods
MH  - Lens Implantation, Intraocular/methods
MH  - Retrospective Studies
MH  - *Uveitis/complications/surgery
MH  - Intraoperative Complications
MH  - Postoperative Complications/surgery
MH  - Risk Factors
MH  - *Cataract/complications
EDAT- 2022/08/25 06:00
MHDA- 2022/12/01 06:00
CRDT- 2022/08/24 19:23
PHST- 2022/03/12 00:00 [received]
PHST- 2022/08/11 00:00 [revised]
PHST- 2022/08/12 00:00 [accepted]
PHST- 2022/08/25 06:00 [pubmed]
PHST- 2022/12/01 06:00 [medline]
PHST- 2022/08/24 19:23 [entrez]
AID - S0002-9394(22)00314-2 [pii]
AID - 10.1016/j.ajo.2022.08.014 [doi]
PST - ppublish
SO  - Am J Ophthalmol. 2022 Dec;244:117-124. doi: 10.1016/j.ajo.2022.08.014. Epub 2022 
      Aug 21.