PMID- 36002102
OWN - NLM
STAT- MEDLINE
DCOM- 20221216
LR  - 20221222
IS  - 2213-2201 (Electronic)
VI  - 10
IP  - 12
DP  - 2022 Dec
TI  - Identification of Potentially Tolerated Fish Species by Multiplex IgE Testing of 
      a Multinational Fish-Allergic Patient Cohort.
PG  - 3284-3292
LID - S2213-2198(22)00824-8 [pii]
LID - 10.1016/j.jaip.2022.08.019 [doi]
AB  - BACKGROUND: Although recent studies indicated that many fish-allergic patients 
      may safely consume certain fish species, no clinical guidelines are available for 
      identification of the exact species tolerated by specific patients. OBJECTIVE: To 
      investigate whether multiplex immunoglobulin E (IgE) testing reveals potentially 
      tolerated fish through absence of IgE to parvalbumin (PV) and extracts from 
      specific species. METHODS: Sera from 263 clinically well-defined fish-allergic 
      patients from Austria, China, Denmark, Luxembourg, Norway, and Spain were used in 
      a research version of the ALEX(2) multiplex IgE quantification assay. Specific 
      IgE to PVs from 10 fish species (9 bony and 1 cartilaginous), and to extracts 
      from 7 species was quantified. The IgE signatures of individual patients and 
      patient groups were analyzed using SPSS and R. RESULTS: Up to 38% of the patients 
      were negative to cod PV, the most commonly used molecule in fish allergy 
      diagnosis. Forty-five patients (17%) tested negative to PVs but positive to the 
      respective fish extracts, underlining the requirement for extracts for accurate 
      diagnosis. Between 60% (Spain) and 90% (Luxembourg) of the patients were negative 
      to PV and extracts from ray, a cartilaginous fish, indicating its potential 
      tolerance. Up to 21% of the patients were negative to at least 1 bony fish 
      species. Of the species analyzed, negativity to mackerel emerged as the best 
      predictive marker of negativity to additional bony fish, such as herring and 
      swordfish. CONCLUSIONS: Parvalbumins and extracts from multiple fish species 
      relevant for consumption should be used in fish-allergy diagnosis, which may help 
      identify potentially tolerated species for individual patients.
CI  - Copyright (c) 2022. Published by Elsevier Inc.
FAU - Kalic, Tanja
AU  - Kalic T
AD  - Department of Dermatology, University Hospital St. Polten, Karl Landsteiner 
      University of Health Sciences, St. Polten, Austria; Institute of Pathophysiology 
      and Allergy Research, Center for Pathophysiology, Infectiology and Immunology, 
      Medical University of Vienna, Vienna, Austria.
FAU - Kuehn, Annette
AU  - Kuehn A
AD  - Department of Infection and Immunity, Luxembourg Institute of Health, 
      Esch-sur-Alzette, Luxembourg.
FAU - Aumayr, Martina
AU  - Aumayr M
AD  - MacroArray Diagnostics, Vienna, Austria.
FAU - Bartra, Joan
AU  - Bartra J
AD  - Allergology Section, Pneumology Department, Hospital Clinic de Barcelona, 
      Barcelona, Spain; August Pi i Sunyer Biomedical Research Institute (IDIBAPS), 
      University of Barcelona, Barcelona, Spain; Allergy Network ARADyAL, Carlos III 
      Health Institute, Madrid, Spain.
FAU - Bindslev-Jensen, Carsten
AU  - Bindslev-Jensen C
AD  - Department of Dermatology and Allergy Center, Odense Research Center for 
      Anaphylaxis, Odense University Hospital, University of Southern Denmark, Odense, 
      Denmark.
FAU - Codreanu-Morel, Francoise
AU  - Codreanu-Morel F
AD  - Department of Allergology and Immunology, Centre Hospitalier de Luxembourg-Kanner 
      Klinik, Luxembourg, Luxembourg.
FAU - Dominguez, Olga
AU  - Dominguez O
AD  - Allergy and Clinical Immunology Department, Hospital Sant Joan de Deu, Esplugues 
      de Llobregat, Spain.
FAU - Forstenlechner, Peter
AU  - Forstenlechner P
AD  - MacroArray Diagnostics, Vienna, Austria.
FAU - Hemmer, Wolfgang
AU  - Hemmer W
AD  - Floridsdorf Allergy Center, Vienna, Austria.
FAU - Kamath, Sandip D
AU  - Kamath SD
AD  - Institute of Pathophysiology and Allergy Research, Center for Pathophysiology, 
      Infectiology and Immunology, Medical University of Vienna, Vienna, Austria; 
      Australian Institute of Tropical Health and Medicine, Molecular Allergy Research 
      Laboratory, James Cook University, Townsville, Queensland, Australia.
FAU - Leung, Agnes
AU  - Leung A
AD  - Department of Pediatrics, Prince of Wales Hospital, The Chinese University of 
      Hong Kong, Hong Kong, China.
FAU - Leung, Nicki
AU  - Leung N
AD  - Department of Pediatrics, Prince of Wales Hospital, The Chinese University of 
      Hong Kong, Hong Kong, China.
FAU - Lifanov, Yuri
AU  - Lifanov Y
AD  - Craftworks GmbH, Vienna, Austria.
FAU - Mortz, Charlotte G
AU  - Mortz CG
AD  - Department of Dermatology and Allergy Center, Odense Research Center for 
      Anaphylaxis, Odense University Hospital, University of Southern Denmark, Odense, 
      Denmark.
FAU - Pascal, Mariona
AU  - Pascal M
AD  - August Pi i Sunyer Biomedical Research Institute (IDIBAPS), University of 
      Barcelona, Barcelona, Spain; Allergy Network ARADyAL, Carlos III Health 
      Institute, Madrid, Spain; Immunology Department, Centre de Diagnostic Biomedic, 
      Hospital Clinic de Barcelona.
FAU - Ristl, Robin
AU  - Ristl R
AD  - Centre for Medical Statistics, Informatics, and Intelligent Systems, Medical 
      University of Vienna, Vienna, Austria.
FAU - Sorensen, Martin
AU  - Sorensen M
AD  - Department of Pediatric and Adolescent Medicine, University Hospital of North 
      Norway, Tromso, Norway.
FAU - Uzulmez, Oyku
AU  - Uzulmez O
AD  - Institute of Pathophysiology and Allergy Research, Center for Pathophysiology, 
      Infectiology and Immunology, Medical University of Vienna, Vienna, Austria.
FAU - Yeghiazaryan, Lusine
AU  - Yeghiazaryan L
AD  - Centre for Medical Statistics, Informatics, and Intelligent Systems, Medical 
      University of Vienna, Vienna, Austria.
FAU - Wong, Gary
AU  - Wong G
AD  - Department of Pediatrics, Prince of Wales Hospital, The Chinese University of 
      Hong Kong, Hong Kong, China.
FAU - Hafner, Christine
AU  - Hafner C
AD  - Department of Dermatology, University Hospital St. Polten, Karl Landsteiner 
      University of Health Sciences, St. Polten, Austria; Karl Landsteiner Institute of 
      Dermatological Research, Karl Landsteiner Gesellschaft, St. Polten, Austria.
FAU - Breiteneder, Heimo
AU  - Breiteneder H
AD  - Institute of Pathophysiology and Allergy Research, Center for Pathophysiology, 
      Infectiology and Immunology, Medical University of Vienna, Vienna, Austria. 
      Electronic address: heimo.breiteneder@meduniwien.ac.at.
LA  - eng
PT  - Journal Article
DEP - 20220821
PL  - United States
TA  - J Allergy Clin Immunol Pract
JT  - The journal of allergy and clinical immunology. In practice
JID - 101597220
RN  - 0 (Allergens)
RN  - 37341-29-0 (Immunoglobulin E)
RN  - 0 (Parvalbumins)
SB  - IM
MH  - Animals
MH  - Humans
MH  - *Allergens
MH  - *Food Hypersensitivity/diagnosis
MH  - Immunoglobulin E
MH  - Fishes
MH  - Parvalbumins
OTO - NOTNLM
OT  - Fish allergy
OT  - Fish extracts
OT  - Fish tolerance
OT  - Food allergy
OT  - IgE
OT  - Multiplex allergy diagnosis
OT  - Parvalbumin
OT  - Patient management
EDAT- 2022/08/25 06:00
MHDA- 2022/12/15 06:00
CRDT- 2022/08/24 19:24
PHST- 2022/03/16 00:00 [received]
PHST- 2022/08/10 00:00 [revised]
PHST- 2022/08/10 00:00 [accepted]
PHST- 2022/08/25 06:00 [pubmed]
PHST- 2022/12/15 06:00 [medline]
PHST- 2022/08/24 19:24 [entrez]
AID - S2213-2198(22)00824-8 [pii]
AID - 10.1016/j.jaip.2022.08.019 [doi]
PST - ppublish
SO  - J Allergy Clin Immunol Pract. 2022 Dec;10(12):3284-3292. doi: 
      10.1016/j.jaip.2022.08.019. Epub 2022 Aug 21.