PMID- 36002360
OWN - NLM
STAT- MEDLINE
DCOM- 20230131
LR  - 20230325
IS  - 1878-3562 (Electronic)
IS  - 1590-8658 (Linking)
VI  - 55
IP  - 2
DP  - 2023 Feb
TI  - Critical signaling pathways governing colitis-associated colorectal cancer: 
      Signaling, therapeutic implications, and challenges.
PG  - 169-177
LID - S1590-8658(22)00631-4 [pii]
LID - 10.1016/j.dld.2022.08.012 [doi]
AB  - Long-term colitis in people with inflammatory bowel disease (IBD) may lead to 
      colon cancer called colitis-associated colorectal cancer (CAC). Since the advent 
      of preclinical prototypes of CAC, various immunological messaging cascades have 
      been identified as implicated in developing this disease. The toll-like receptor 
      (TLR)s, Janus kinase (JAK)-signal transducer and activator of transcription 
      (STAT), Nuclear factor-kappa B (NF-kappaB), mammalian target of rapamycin complex 
      (mTOR), autophagy, and oxidative stress are only a few of the molecular 
      mechanisms that have been recognized as major components to CAC progression. 
      These pathways may also represent attractive medicinal candidates for the 
      prevention and management of CAC. CAC signaling mechanisms at the molecular level 
      and how their dysregulation may cause illness are summarized in this 
      comprehensive overview.
CI  - Copyright (c) 2022. Published by Elsevier Ltd.
FAU - Xin, Jiang
AU  - Xin J
AD  - Department of Gastrointestinal Surgery, The Third People's hospital of Qingdao, 
      266000, China. Electronic address: xj811020@126.com.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20220821
PL  - Netherlands
TA  - Dig Liver Dis
JT  - Digestive and liver disease : official journal of the Italian Society of 
      Gastroenterology and the Italian Association for the Study of the Liver
JID - 100958385
RN  - 0 (NF-kappa B)
SB  - IM
MH  - Humans
MH  - *Colitis-Associated Neoplasms/complications
MH  - Signal Transduction
MH  - *Colitis/complications/metabolism
MH  - *Colonic Neoplasms/etiology
MH  - *Inflammatory Bowel Diseases/complications
MH  - NF-kappa B/metabolism
OTO - NOTNLM
OT  - Colitis
OT  - Colorectal cancer
OT  - Crohn's disease
OT  - IBD
OT  - Signaling
COIS- Conflict of interest None declared.
EDAT- 2022/08/25 06:00
MHDA- 2023/02/01 06:00
CRDT- 2022/08/24 22:03
PHST- 2022/02/24 00:00 [received]
PHST- 2022/07/05 00:00 [revised]
PHST- 2022/08/03 00:00 [accepted]
PHST- 2022/08/25 06:00 [pubmed]
PHST- 2023/02/01 06:00 [medline]
PHST- 2022/08/24 22:03 [entrez]
AID - S1590-8658(22)00631-4 [pii]
AID - 10.1016/j.dld.2022.08.012 [doi]
PST - ppublish
SO  - Dig Liver Dis. 2023 Feb;55(2):169-177. doi: 10.1016/j.dld.2022.08.012. Epub 2022 
      Aug 21.