PMID- 36002618 OWN - NLM STAT- MEDLINE DCOM- 20221003 LR - 20230318 IS - 1970-9366 (Electronic) IS - 1828-0447 (Print) IS - 1828-0447 (Linking) VI - 17 IP - 7 DP - 2022 Oct TI - Association of waist circumference with haemoglobin A1c and its optimal cutoff for identifying prediabetes and diabetes risk in the Chinese population. PG - 2039-2044 LID - 10.1007/s11739-022-03072-z [doi] AB - Haemoglobin A1c (HbA1c) is a marker of glycaemic control in type 2 diabetes mellitus (T2DM). Increased waist circumference (WC) is known to be associated with T2DM. Therefore, we investigated the relationship of WC with HbA1c and explored its optimal cutoff for identifying prediabetes and diabetes risk. This study included 2339 participants between 18 and 84 years of age [mean (SD) age, 43.5 (11.9) years] with valid data on WC, HbA1c and related variables in the Shenzhen-Hong Kong United Network on Cardiovascular Disease study. Participants on anti-diabetic medications were excluded. Multiple linear regression was used to investigate the relationship between HbA1c and WC. Cutoff values of WC indicating an HbA1c level of 5.7% and 6.5% were also assessed using optimal binning. There was a significant linear relationship between WC and HbA1c in the overall population (B = 0.261, P < 0.001), men (B = 0.206, P < 0.001) and women (B = 0.311, P < 0.001). After adjustment for smoking, alcohol consumption, physical activity, hypertension, hypercholesterolaemia and age, the association remained significant in the overall population (B = 0.201, P < 0.001), men (B = 0.186, P < 0.001) and women (B = 0.182, P < 0.001). The optimal cutoff values of WC indicating an HbA1c level of 5.7% and 6.5% was 83 cm (entropy = 0.943) and 85 cm (entropy = 0.365) in men, and 78 cm (entropy = 0.922) and 86 cm (entropy = 0.256) in women. The linear relationship between WC and HbA1c in this study suggests that addressing central obesity issue is beneficial to people with T2DM or at risk of T2DM. WC cutoff values of 85 cm for men and 86 cm for women are appropriate for recommendation to undergo diabetes screening. CI - (c) 2022. The Author(s). FAU - Zhen, Juanying AU - Zhen J AD - Department of Medicine, School of Clinical Medicine, The University of Hong Kong, Queen Mary Hospital, Pokfulam, Hong Kong SAR, China. AD - Department of Neurology, Peking University Shenzhen Hospital, Shenzhen, China. FAU - Liu, Shuyun AU - Liu S AD - Department of Neurology, Shenzhen Longhua District Central Hospital, Shenzhen, China. FAU - Zhao, Guoru AU - Zhao G AD - CAS Key Laboratory of Human-Machine Intelligence-Synergy Systems, Research Center for Neural Engineering, Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences, Shenzhen, China. FAU - Peng, Hao AU - Peng H AD - Department of Epidemiology, School of Public Health, Medical College of Soochow University, Suzhou, China. FAU - Samaranayake, Nithushi AU - Samaranayake N AD - Department of Pharmacy and Pharmaceutical Sciences, Faculty of Allied Health Sciences, University of Sri Jayewardenepura, Nugegoda, Sri Lanka. FAU - Xu, Aimin AU - Xu A AD - Department of Medicine, School of Clinical Medicine, The University of Hong Kong, Queen Mary Hospital, Pokfulam, Hong Kong SAR, China. AD - State Key Laboratory of Pharmaceutical Biotechnology, The University of Hong Kong, Pokfulam, Hong Kong SAR, China. FAU - Li, Chao AU - Li C AUID- ORCID: 0000-0002-7543-3973 AD - Department of Medicine, School of Clinical Medicine, The University of Hong Kong, Queen Mary Hospital, Pokfulam, Hong Kong SAR, China. dcli@connect.hku.hk. AD - Department of Neurology, Peking University Shenzhen Hospital, Shenzhen, China. dcli@connect.hku.hk. AD - State Key Laboratory of Pharmaceutical Biotechnology, The University of Hong Kong, Pokfulam, Hong Kong SAR, China. dcli@connect.hku.hk. FAU - Wu, Jun AU - Wu J AD - Department of Neurology, Peking University Shenzhen Hospital, Shenzhen, China. Wujun188@163.com. FAU - Cheung, Bernard Man Yung AU - Cheung BMY AUID- ORCID: 0000-0001-9106-7363 AD - Department of Medicine, School of Clinical Medicine, The University of Hong Kong, Queen Mary Hospital, Pokfulam, Hong Kong SAR, China. mycheung@hku.hk. AD - State Key Laboratory of Pharmaceutical Biotechnology, The University of Hong Kong, Pokfulam, Hong Kong SAR, China. mycheung@hku.hk. AD - Institute of Cardiovascular Science and Medicine, The University of Hong Kong, Hong Kong SAR, China. mycheung@hku.hk. LA - eng GR - GHP/138/18SZ/Innovation and Technology Commission - Hong Kong/ GR - SGLH20180629094602262/Science, Technology and Innovation Commission of Shenzhen Municipality/ PT - Journal Article PT - Research Support, Non-U.S. Gov't DEP - 20220824 PL - Italy TA - Intern Emerg Med JT - Internal and emergency medicine JID - 101263418 RN - 0 (Glycated Hemoglobin A) SB - IM CIN - Intern Emerg Med. 2022 Oct;17(7):1859-1861. PMID: 36040676 MH - Adult MH - Body Mass Index MH - Child MH - China/epidemiology MH - *Diabetes Mellitus, Type 2/diagnosis/epidemiology MH - Female MH - Glycated Hemoglobin MH - Humans MH - Male MH - *Prediabetic State/diagnosis/epidemiology MH - Risk Factors MH - Waist Circumference PMC - PMC9522717 OTO - NOTNLM OT - Central obesity OT - Haemoglobin A1c OT - Type 2 diabetes mellitus OT - Waist circumference COIS- The authors have no conflicts of interest to declare that are relevant to the content of this article. EDAT- 2022/08/25 06:00 MHDA- 2022/10/04 06:00 PMCR- 2022/08/24 CRDT- 2022/08/24 23:27 PHST- 2022/05/22 00:00 [received] PHST- 2022/07/29 00:00 [accepted] PHST- 2022/08/25 06:00 [pubmed] PHST- 2022/10/04 06:00 [medline] PHST- 2022/08/24 23:27 [entrez] PHST- 2022/08/24 00:00 [pmc-release] AID - 10.1007/s11739-022-03072-z [pii] AID - 3072 [pii] AID - 10.1007/s11739-022-03072-z [doi] PST - ppublish SO - Intern Emerg Med. 2022 Oct;17(7):2039-2044. doi: 10.1007/s11739-022-03072-z. Epub 2022 Aug 24.