PMID- 36003048
OWN - NLM
STAT- MEDLINE
DCOM- 20220826
LR  - 20221015
IS  - 1399-3038 (Electronic)
IS  - 0905-6157 (Print)
IS  - 0905-6157 (Linking)
VI  - 33
IP  - 8
DP  - 2022 Aug
TI  - Cord blood IgE predicts allergic sensitization, elevation of exhaled nitric 
      oxide, and asthma in schoolchildren.
PG  - e13838
LID - 10.1111/pai.13838 [doi]
LID - e13838
AB  - BACKGROUND: Few data are available in Asian children regarding the validity of 
      cord blood immunoglobulin E (IgE) in predicting allergic sensitization and 
      pulmonary function. The relationship between cord blood IgE and fraction of 
      exhaled nitric oxide (FeNO) remains unknown. This study investigated the 
      associations of cord blood IgE with allergic sensitization, FeNO, pulmonary 
      function, and allergic diseases in Asian children. METHODS: Five hundred and 
      sixty-six Asian children with valid cord blood IgE measurements at birth 
      participated a 6-year follow-up visit including a questionnaire, serum total and 
      allergen-specific IgE, FeNO measurement, and spirometry. Regression-based 
      analyses with covariates adjustment were applied. RESULTS: Cord blood IgE levels 
      were significantly associated with FeNO levels (beta = 0.131, p < .001) and serum 
      total IgE levels (beta = 0.325, p < .001). Cord blood IgE levels were positively 
      associated with allergic sensitization (adjusted odds ratio [AOR] = 2.22, 
      p < .001), and sensitization to mites (p = .002), animals (p = .023), and foods 
      (p = .048). Subjects with cord blood IgE >/=0.24 kU/L (the optimal cutoff) were 
      significantly associated with an increased risk of allergic sensitization 
      (AOR = 2.63, p < .001) and asthma (AOR = 2.35, p = .024) than those with cord 
      blood IgE <0.24 kU/L. Subjects with cord blood IgE >/=0.24 kU/L had significantly 
      higher FeNO levels than those with cord blood IgE <0.24 kU/L (p = .028). There 
      were no significant associations between cord blood IgE levels and pulmonary 
      function parameters. CONCLUSION: Cord blood IgE >/=0.24 kU/L predicts allergic 
      sensitization, FeNO elevation, and asthma among Asian schoolchildren, suggesting 
      cord blood IgE would be useful for identifying newborns at risk of subsequent 
      allergic sensitization and allergic airway inflammation.
CI  - (c) 2022 The Authors. Pediatric Allergy and Immunology published by European 
      Academy of Allergy and Clinical Immunology and John Wiley & Sons Ltd.
FAU - Lee, Hsin-Ju
AU  - Lee HJ
AD  - Division of Allergy, Asthma, and Rheumatology, Department of Pediatrics, Chang 
      Gung Memorial Hospital, Taoyuan, Taiwan.
FAU - Tsai, Hui-Ju
AU  - Tsai HJ
AUID- ORCID: 0000-0002-5338-6117
AD  - Institute of Population Health Sciences, National Health Research Institutes, 
      Miaoli, Taiwan.
FAU - Huang, Hsin-Yi
AU  - Huang HY
AD  - Division of Allergy, Asthma, and Rheumatology, Department of Pediatrics, Chang 
      Gung Memorial Hospital, Taoyuan, Taiwan.
FAU - Gau, Chun-Chun
AU  - Gau CC
AD  - Division of Allergy, Asthma, and Rheumatology, Department of Pediatrics, Chang 
      Gung Memorial Hospital, Taoyuan, Taiwan.
AD  - Division of Pediatric General Medicine, Department of Pediatrics, Chang Gung 
      Memorial Hospital, Taoyuan, Taiwan.
AD  - Department of Pediatrics, New Taipei Municipal TuCheng Hospital, New Taipei, 
      Taiwan.
FAU - Ho, Chia-Hua
AU  - Ho CH
AD  - Department of Medical Education, Chang Gung Memorial Hospital, Taoyuan, Taiwan.
FAU - Huang, Jing-Long
AU  - Huang JL
AUID- ORCID: 0000-0001-9280-920X
AD  - Division of Allergy, Asthma, and Rheumatology, Department of Pediatrics, Chang 
      Gung Memorial Hospital, Taoyuan, Taiwan.
AD  - Department of Pediatrics, New Taipei Municipal TuCheng Hospital, New Taipei, 
      Taiwan.
AD  - School of Medicine, Chang Gung University College of Medicine, Taoyuan, Taiwan.
FAU - Yao, Tsung-Chieh
AU  - Yao TC
AUID- ORCID: 0000-0002-5457-1402
AD  - Division of Allergy, Asthma, and Rheumatology, Department of Pediatrics, Chang 
      Gung Memorial Hospital, Taoyuan, Taiwan.
AD  - School of Medicine, Chang Gung University College of Medicine, Taoyuan, Taiwan.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Pediatr Allergy Immunol
JT  - Pediatric allergy and immunology : official publication of the European Society 
      of Pediatric Allergy and Immunology
JID - 9106718
RN  - 31C4KY9ESH (Nitric Oxide)
RN  - 37341-29-0 (Immunoglobulin E)
SB  - IM
MH  - Animals
MH  - *Asthma/complications/diagnosis/epidemiology
MH  - Exhalation
MH  - Fetal Blood
MH  - Humans
MH  - Immunoglobulin E
MH  - *Nitric Oxide/analysis
PMC - PMC9541746
OTO - NOTNLM
OT  - allergic sensitization
OT  - asthma
OT  - cord blood IgE
OT  - exhaled nitric oxide
OT  - pulmonary function
COIS- The authors declare no conflict of interest.
EDAT- 2022/08/26 06:00
MHDA- 2022/08/27 06:00
PMCR- 2022/10/07
CRDT- 2022/08/25 02:02
PHST- 2022/06/24 00:00 [revised]
PHST- 2022/02/24 00:00 [received]
PHST- 2022/07/17 00:00 [accepted]
PHST- 2022/08/25 02:02 [entrez]
PHST- 2022/08/26 06:00 [pubmed]
PHST- 2022/08/27 06:00 [medline]
PHST- 2022/10/07 00:00 [pmc-release]
AID - PAI13838 [pii]
AID - 10.1111/pai.13838 [doi]
PST - ppublish
SO  - Pediatr Allergy Immunol. 2022 Aug;33(8):e13838. doi: 10.1111/pai.13838.