PMID- 36004352 OWN - NLM STAT- MEDLINE DCOM- 20220826 LR - 20220826 IS - 1664-2392 (Print) IS - 1664-2392 (Electronic) IS - 1664-2392 (Linking) VI - 13 DP - 2022 TI - Associations between rs3480 and rs16835198 gene polymorphisms of FNDC5 with type 2 diabetes mellitus susceptibility: a meta-analysis. PG - 946982 LID - 10.3389/fendo.2022.946982 [doi] LID - 946982 AB - BACKGROUND: FNDC5 is a novel and important player in energy regulation related to glucose metabolism and insulin levels. Thus, it may affect the incidence of type 2 diabetes mellitus (T2DM). Nevertheless, the association between FNDC5 single nucleotide polymorphisms (SNPs) and susceptibility to T2DM remains unclear. The aim of this meta-analysis was to explore whether the SNPs, rs3480 and rs16835198, are associated with the risk of T2DM. METHODS: Studies published before February 1(st), 2022 were screened to identify the included studies. R software was also applied for calculation of odds ratio (OR), 95% confidence interval (95% CI), heterogeneity, and sensitivity analysis. RESULTS: Seven studies for rs3480 (involving 5475 patients with T2DM and 4855 healthy controls) and five studies for rs16835198 (involving 4217 patients with T2DM and 4019 healthy controls) were included in this meta-analysis. The results revealed a statistically significant association of rs3480 with T2DM under homozygote (GG vs AA: OR = 1.76, 95% CI = 1.31-2.37, P = 0.0002, I(2) = 59%) genetic model. However, there was no statistically significant correlation between rs16835198 and susceptibility to T2DM under allelic (G vs T: OR = 1.33, 95% CI = 0.94-1.89, P = 0.11, I(2) = 84%), heterozygote (GT vs TT: OR = 1.17, 95% CI = 0.80-1.69, P = 0.42, I(2) = 71%), homozygote (GG vs TT: OR = 1.35, 95% CI = 0.95-1.94, P = 0.10, I(2) = 62%), recessive (GG+GT vs TT: OR = 1.25, 95% CI = 0.88-1.79, P = 0.22, I(2) = 72%), and dominant (GG vs GT+GG: OR = 1.20, 95% CI = 0.96-1.50, P = 0.11, I(2) = 46%) genetic models. CONCLUSIONS: The present meta-analysis revealed that rs3480 in FNDC5 is significantly associated with susceptibility to T2DM, while rs16835198 does not show such an association. CI - Copyright (c) 2022 Yang, Ni, Sun, Yuan and Li. FAU - Yang, Xianqin AU - Yang X AD - Department of Emergency, Central Hospital of Enshi Tujia and Miao Autonomous Prefecture, Enshi, China. FAU - Ni, Li AU - Ni L AD - Heart Function Examination Room, Wuhan Third Hospital & Tongren Hospital of Wuhan University, Wuhan, China. FAU - Sun, Junyu AU - Sun J AD - College of Health and Nursing, Wuchang University of Technology, Wuhan, China. FAU - Yuan, Xiaolu AU - Yuan X AD - Department of Pathology, Maoming People' s Hospital, Maoming, China. FAU - Li, Dezhong AU - Li D AD - Department of Emergency, Central Hospital of Enshi Tujia and Miao Autonomous Prefecture, Enshi, China. LA - eng PT - Meta-Analysis PT - Systematic Review DEP - 20220808 PL - Switzerland TA - Front Endocrinol (Lausanne) JT - Frontiers in endocrinology JID - 101555782 RN - 0 (FNDC5 protein, human) RN - 0 (Fibronectins) RN - 0 (Transcription Factors) SB - IM MH - Alleles MH - *Diabetes Mellitus, Type 2/genetics MH - Fibronectins/genetics MH - Homozygote MH - Humans MH - Polymorphism, Single Nucleotide MH - Transcription Factors/genetics PMC - PMC9393395 OTO - NOTNLM OT - FNDC5 OT - meta-analysis OT - polymorphism OT - susceptibility OT - type 2 diabetes mellitus COIS- The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2022/08/26 06:00 MHDA- 2022/08/27 06:00 PMCR- 2022/01/01 CRDT- 2022/08/25 02:33 PHST- 2022/05/18 00:00 [received] PHST- 2022/07/11 00:00 [accepted] PHST- 2022/08/25 02:33 [entrez] PHST- 2022/08/26 06:00 [pubmed] PHST- 2022/08/27 06:00 [medline] PHST- 2022/01/01 00:00 [pmc-release] AID - 10.3389/fendo.2022.946982 [doi] PST - epublish SO - Front Endocrinol (Lausanne). 2022 Aug 8;13:946982. doi: 10.3389/fendo.2022.946982. eCollection 2022.