PMID- 36005444
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220828
IS  - 2308-3425 (Electronic)
IS  - 2308-3425 (Linking)
VI  - 9
IP  - 8
DP  - 2022 Aug 20
TI  - Circulating Monocyte Chemoattractant Protein-1 in Patients with Cardiogenic Shock 
      Complicating Acute Myocardial Infarction Treated with Mild Hypothermia: A 
      Biomarker Substudy of SHOCK-COOL Trial.
LID - 10.3390/jcdd9080280 [doi]
LID - 280
AB  - BACKGROUND: There is evidence that monocyte chemoattractant protein-1 (MCP-1) 
      levels reflect the intensity of the inflammatory response in patients with 
      cardiogenic shock (CS) complicating acute myocardial infarction (AMI) and have a 
      predictive value for clinical outcomes. However, little is known about the effect 
      of mild therapeutic hypothermia (MTH) on the inflammatory response in patients 
      with CS complicating AMI. Therefore, we conducted a biomarker study to 
      investigate the effect of MTH on MCP-1 levels in patients with CS complicating 
      AMI. METHODS: In the randomized mild hypothermia in cardiogenic shock 
      (SHOCK-COOL) trial, 40 patients with CS complicating AMI were enrolled and 
      assigned to MTH (33  degrees C) for 24 h or normothermia at a 1:1 ratio. Blood samples 
      were collected at predefined time points at the day of admission/day 1, day 2 and 
      day 3. Differences in MCP-1 levels between and within the MTH and normothermia 
      groups were assessed. Additionally, the association of MCP-1 levels with the risk 
      of all-cause mortality at 30 days was analyzed. Missing data were accounted for 
      by multiple imputation as sensitivity analyses. RESULTS: There were differences 
      in MCP-1 levels over time between patients in MTH and normothermia groups (P for 
      interaction = 0.013). MCP-1 levels on day 3 were higher than on day 1 in the MTH 
      group (day 1 vs day 3: 21.2 [interquartile range, 0.25-79.9] vs. 125.7 
      [interquartile range, 87.3-165.4] pg/mL; p = 0.006) and higher than in the 
      normothermia group at day 3 (MTH 125.7 [interquartile range, 87.3-165.4] vs. 
      normothermia 12.3 [interquartile range, 0-63.9] pg/mL; p = 0.011). Irrespective 
      of therapy, patients with higher levels of MCP-1 at hospitalization tended to 
      have a decreased risk of all-cause mortality at 30 days (HR, 2.61; 95% CI 
      0.997-6.83; p = 0.051). CONCLUSIONS: The cooling phase of MTH had no significant 
      effect on MCP-1 levels in patients with CS complicating AMI compared to 
      normothermic control, whereas MCP-1 levels significantly increased after 
      rewarming. TRIAL REGISTRATION: NCT01890317.
FAU - Cheng, Wenke
AU  - Cheng W
AUID- ORCID: 0000-0001-7105-037X
AD  - Department of Internal Medicine/Cardiology, Heart Center Leipzig at University of 
      Leipzig, 04289 Leipzig, Germany.
AD  - Medical Faculty, University of Leipzig, 04103 Leipzig, Germany.
FAU - Fuernau, Georg
AU  - Fuernau G
AUID- ORCID: 0000-0002-3813-8772
AD  - Clinic for Internal Medicine II (Cardiology, Angiology, Diabetology, Intensive 
      Care Medicine), Dessau Community General Hospital, 06847 Dessau-Rosslau, Germany.
FAU - Desch, Steffen
AU  - Desch S
AD  - Department of Internal Medicine/Cardiology, Heart Center Leipzig at University of 
      Leipzig, 04289 Leipzig, Germany.
FAU - Freund, Anne
AU  - Freund A
AD  - Department of Internal Medicine/Cardiology, Heart Center Leipzig at University of 
      Leipzig, 04289 Leipzig, Germany.
FAU - Feistritzer, Hans-Josef
AU  - Feistritzer HJ
AD  - Department of Internal Medicine/Cardiology, Heart Center Leipzig at University of 
      Leipzig, 04289 Leipzig, Germany.
FAU - Poss, Janine
AU  - Poss J
AD  - Department of Internal Medicine/Cardiology, Heart Center Leipzig at University of 
      Leipzig, 04289 Leipzig, Germany.
FAU - Buettner, Petra
AU  - Buettner P
AUID- ORCID: 0000-0003-0799-4725
AD  - Department of Internal Medicine/Cardiology, Heart Center Leipzig at University of 
      Leipzig, 04289 Leipzig, Germany.
FAU - Thiele, Holger
AU  - Thiele H
AUID- ORCID: 0000-0002-0169-998X
AD  - Department of Internal Medicine/Cardiology, Heart Center Leipzig at University of 
      Leipzig, 04289 Leipzig, Germany.
LA  - eng
SI  - ClinicalTrials.gov/NCT01890317
PT  - Journal Article
DEP - 20220820
PL  - Switzerland
TA  - J Cardiovasc Dev Dis
JT  - Journal of cardiovascular development and disease
JID - 101651414
PMC - PMC9410223
OTO - NOTNLM
OT  - acute myocardial infarction
OT  - cardiogenic shock
OT  - mild therapeutic hypothermia
OT  - monocyte chemoattractant protein-1
COIS- The authors declare that they have no conflict of interest.
EDAT- 2022/08/26 06:00
MHDA- 2022/08/26 06:01
PMCR- 2022/08/20
CRDT- 2022/08/25 08:04
PHST- 2022/07/20 00:00 [received]
PHST- 2022/08/17 00:00 [revised]
PHST- 2022/08/18 00:00 [accepted]
PHST- 2022/08/25 08:04 [entrez]
PHST- 2022/08/26 06:00 [pubmed]
PHST- 2022/08/26 06:01 [medline]
PHST- 2022/08/20 00:00 [pmc-release]
AID - jcdd9080280 [pii]
AID - jcdd-09-00280 [pii]
AID - 10.3390/jcdd9080280 [doi]
PST - epublish
SO  - J Cardiovasc Dev Dis. 2022 Aug 20;9(8):280. doi: 10.3390/jcdd9080280.