PMID- 36009365
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20230308
IS  - 2227-9059 (Print)
IS  - 2227-9059 (Electronic)
IS  - 2227-9059 (Linking)
VI  - 10
IP  - 8
DP  - 2022 Jul 28
TI  - Relationship between the Soluble F11 Receptor and Annexin A5 in African Americans 
      Patients with Type-2 Diabetes Mellitus.
LID - 10.3390/biomedicines10081818 [doi]
LID - 1818
AB  - Type 2 diabetes mellitus (T2DM) is characterized by endothelial dysfunction, 
      increased thrombogenicity, and inflammation. The soluble human F11 receptor 
      (sF11R) and annexin A5 (ANXA5) play crucial roles in inflammatory thrombosis and 
      atherosclerosis. We examined the relationship between circulating sF11R and ANXA5 
      and their impact on endothelial function. The study included 125 patients with 
      T2DM. Plasma levels of sF11R and ANXA5 were quantified by ELISA. Microvascular 
      function was assessed using the vascular reactivity index (VRI). Large artery 
      stiffness was assessed by carotid-femoral pulse wave velocity (PWV). Carotid 
      intima-media thickness (CIMT) was assessed by B-mode ultrasound imaging. The mean 
      age of patients in the study was 59.7 +/- 7.8 years, 78% had hypertension, 76% had 
      dyslipidemia, and 12% had CKD. sF11R correlated positively with ANXA5 levels (beta = 
      0.250, p = 0.005), and correlated inversely with VRI and total nitic oxide (NO), 
      (beta = -0.201, p = 0.024; beta = -0.357, p = 0.0001, respectively). Multivariate 
      regression analysis revealed that sF11R was independently associated with ANXA5 
      in the total population and in patients with HbA1c > 6.5% (beta = 0.366, p = 0.007; 
      beta = 0.425, p = 0.0001, respectively). sF11R and ANXA5 were not associated with 
      vascular outcome, suggesting that they may not be reliable markers of vascular 
      dysfunction in diabetes. The clinical significance of sF11R/ANXA5 association in 
      diabetes warrants further investigation in a larger population.
FAU - Adedayo, Ajibola
AU  - Adedayo A
AD  - Department of Medicine, Downstate Medical Center, State University of New York, 
      450 Clarkson Ave., Brooklyn, New York, NY 11203, USA.
FAU - Eluwole, Ayobami
AU  - Eluwole A
AD  - Department of Medicine, Downstate Medical Center, State University of New York, 
      450 Clarkson Ave., Brooklyn, New York, NY 11203, USA.
FAU - Tedla, Fasika
AU  - Tedla F
AD  - Department of Medicine, Downstate Medical Center, State University of New York, 
      450 Clarkson Ave., Brooklyn, New York, NY 11203, USA.
FAU - Kremer, Arye
AU  - Kremer A
AD  - Department of Medicine, Downstate Medical Center, State University of New York, 
      450 Clarkson Ave., Brooklyn, New York, NY 11203, USA.
FAU - Khan, Muhammad
AU  - Khan M
AD  - Department of Medicine, Downstate Medical Center, State University of New York, 
      450 Clarkson Ave., Brooklyn, New York, NY 11203, USA.
FAU - Mastrogiovanni, Nicole
AU  - Mastrogiovanni N
AUID- ORCID: 0000-0001-7333-9572
AD  - Department of Medicine, Downstate Medical Center, State University of New York, 
      450 Clarkson Ave., Brooklyn, New York, NY 11203, USA.
FAU - Rosenberg, Carl
AU  - Rosenberg C
AD  - Department of Epidemiology and Biostatistics, School of Public Health, SUNY 
      Downstate Health Sciences University, 450 Clarkson Ave., Brooklyn, New York, NY 
      11203, USA.
FAU - Dreizen, Paul
AU  - Dreizen P
AD  - Department of Medicine, Downstate Medical Center, State University of New York, 
      450 Clarkson Ave., Brooklyn, New York, NY 11203, USA.
FAU - La Rosa, John
AU  - La Rosa J
AD  - Department of Medicine, Downstate Medical Center, State University of New York, 
      450 Clarkson Ave., Brooklyn, New York, NY 11203, USA.
FAU - Salciccioli, Louis
AU  - Salciccioli L
AD  - Department of Medicine, Downstate Medical Center, State University of New York, 
      450 Clarkson Ave., Brooklyn, New York, NY 11203, USA.
FAU - Boutjdir, Mohamed
AU  - Boutjdir M
AD  - Department of Medicine, Downstate Medical Center, State University of New York, 
      450 Clarkson Ave., Brooklyn, New York, NY 11203, USA.
FAU - Banerji, Mary Ann
AU  - Banerji MA
AD  - Department of Medicine, Downstate Medical Center, State University of New York, 
      450 Clarkson Ave., Brooklyn, New York, NY 11203, USA.
FAU - Brown, Clinton
AU  - Brown C
AD  - Department of Medicine, Downstate Medical Center, State University of New York, 
      450 Clarkson Ave., Brooklyn, New York, NY 11203, USA.
FAU - Lazar, Jason
AU  - Lazar J
AUID- ORCID: 0000-0002-8548-7932
AD  - Department of Medicine, Downstate Medical Center, State University of New York, 
      450 Clarkson Ave., Brooklyn, New York, NY 11203, USA.
FAU - Salifu, Moro
AU  - Salifu M
AD  - Department of Medicine, Downstate Medical Center, State University of New York, 
      450 Clarkson Ave., Brooklyn, New York, NY 11203, USA.
FAU - Bakillah, Ahmed
AU  - Bakillah A
AUID- ORCID: 0000-0001-5434-1976
AD  - Department of Medicine, Downstate Medical Center, State University of New York, 
      450 Clarkson Ave., Brooklyn, New York, NY 11203, USA.
AD  - King Abdullah International Medical Research Center (KAIMRC), King Saud bin 
      Abdulaziz University for Health Sciences (KSAU-HS), Ministry of National Guard 
      Health Affairs, Al Ahsa 31982, Saudi Arabia.
LA  - eng
GR  - ECRIP, 2015-2016/The New York State Department of Health/
PT  - Journal Article
DEP - 20220728
PL  - Switzerland
TA  - Biomedicines
JT  - Biomedicines
JID - 101691304
PMC - PMC9405000
OTO - NOTNLM
OT  - F11R
OT  - annexins
OT  - artery stiffness
OT  - biomarkers
OT  - cardiovascular disease
OT  - diabetes
OT  - endothelium function
OT  - vascular complications
OT  - vascular reactivity index
COIS- The authors declare no conflict of interest. The funders had no role in the 
      design of the study; in the collection, analyses, or interpretation of data; in 
      the writing of the manuscript, or in the decision to publish the results.
EDAT- 2022/08/27 06:00
MHDA- 2022/08/27 06:01
PMCR- 2022/07/28
CRDT- 2022/08/26 01:05
PHST- 2022/04/25 00:00 [received]
PHST- 2022/06/10 00:00 [revised]
PHST- 2022/06/15 00:00 [accepted]
PHST- 2022/08/26 01:05 [entrez]
PHST- 2022/08/27 06:00 [pubmed]
PHST- 2022/08/27 06:01 [medline]
PHST- 2022/07/28 00:00 [pmc-release]
AID - biomedicines10081818 [pii]
AID - biomedicines-10-01818 [pii]
AID - 10.3390/biomedicines10081818 [doi]
PST - epublish
SO  - Biomedicines. 2022 Jul 28;10(8):1818. doi: 10.3390/biomedicines10081818.