PMID- 36010137
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20230308
IS  - 2227-9067 (Print)
IS  - 2227-9067 (Electronic)
IS  - 2227-9067 (Linking)
VI  - 9
IP  - 8
DP  - 2022 Aug 18
TI  - Does a Gluten-Free Diet Affect BMI and Glycosylated Hemoglobin in Children and 
      Adolescents with Type 1 Diabetes and Asymptomatic Celiac Disease? A Meta-Analysis 
      and Systematic Review.
LID - 10.3390/children9081247 [doi]
LID - 1247
AB  - Background: Children diagnosed with type 1 diabetes mellitus (T1DM) are more 
      prone to having celiac disease (CD) than the normal population. Moreover, 
      patients with this dual diagnosis who are also on a diabetic and gluten-free diet 
      (GFD) risk faltering growth and uncontrolled blood glucose levels. This review 
      aims to assess the efficacy and effectiveness of managing patients with T1DM 
      screened for CD with GFD to prevent complications associated with these chronic 
      pathologies in childhood and adulthood. Materials and Methods: We abided by the 
      PRISMA guidelines in this meta-analysis and used multiple databases and search 
      engines. We included case-control studies. The primary outcomes were changes in 
      the standard deviation score, body mass index (SDS BMI), and glycosylated 
      hemoglobin (HA1C) after being on a GFD for at least twelve months. Results: The 
      pooled data from the six studies included showed that there was neither a 
      statistically significant difference in the mean SDS BMI (-0.28 (95% CI -0.75, 
      0.42)) (p = 0.24) nor in the mean of HA1C (mean -0.07 (95% CI -0.44, 0.30)) (p = 
      0.36) for the same group. HDL cholesterol improved significantly in patients on a 
      strict GFD (p < 0.01). Conclusions: In children with T1DM and asymptomatic CD, 
      being on a GFD had no significant effect on BMI or HA1C. However, it can have a 
      protective effect on the other complications found in both chronic pathologies.
FAU - Burayzat, Salma
AU  - Burayzat S
AUID- ORCID: 0000-0001-7265-5055
AD  - Pediatric Gastroenterology, Hepatology and Nutrition, Faculty of Medicine, 
      Pediatrics Department, The Hashemite University, Zarqa 13133, Jordan.
FAU - Elsahoryi, Nour
AU  - Elsahoryi N
AD  - Faculty of Pharmacy and Medical Sciences, Nutrition Department, University of 
      Petra, Amman 961343, Jordan.
FAU - Freitekh, Ali
AU  - Freitekh A
AD  - Faculty of Medicine, The Hashemite University, Zarqa 13133, Jordan.
FAU - Alzoubi, Osama
AU  - Alzoubi O
AUID- ORCID: 0000-0001-8196-3922
AD  - Faculty of Medicine, Jordan University, Amman 11942, Jordan.
FAU - Al-Najjar, Rahaf
AU  - Al-Najjar R
AUID- ORCID: 0000-0003-0968-9820
AD  - Faculty of Medicine, The Hashemite University, Zarqa 13133, Jordan.
FAU - Tayyem, Reema
AU  - Tayyem R
AUID- ORCID: 0000-0003-1640-0511
AD  - Department of Human Nutrition, College of Health Sciences, Qatar University, Doha 
      P.O. Box 2713, Qatar.
AD  - Faculty of Agriculture, University of Jordan, Amman 11942, Jordan.
LA  - eng
PT  - Journal Article
DEP - 20220818
PL  - Switzerland
TA  - Children (Basel)
JT  - Children (Basel, Switzerland)
JID - 101648936
PMC - PMC9406674
OTO - NOTNLM
OT  - HA1C
OT  - body mass index
OT  - celiac disease
OT  - gluten-free diet
OT  - type 1 diabetes mellitus
COIS- None of the authors declare any conflict of interest.
EDAT- 2022/08/27 06:00
MHDA- 2022/08/27 06:01
PMCR- 2022/08/18
CRDT- 2022/08/26 01:09
PHST- 2022/07/12 00:00 [received]
PHST- 2022/07/30 00:00 [revised]
PHST- 2022/08/01 00:00 [accepted]
PHST- 2022/08/26 01:09 [entrez]
PHST- 2022/08/27 06:00 [pubmed]
PHST- 2022/08/27 06:01 [medline]
PHST- 2022/08/18 00:00 [pmc-release]
AID - children9081247 [pii]
AID - children-09-01247 [pii]
AID - 10.3390/children9081247 [doi]
PST - epublish
SO  - Children (Basel). 2022 Aug 18;9(8):1247. doi: 10.3390/children9081247.