PMID- 36010296
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20230308
IS  - 2075-4418 (Print)
IS  - 2075-4418 (Electronic)
IS  - 2075-4418 (Linking)
VI  - 12
IP  - 8
DP  - 2022 Aug 12
TI  - miR-146a-5p, miR-223-3p and miR-142-3p as Potential Predictors of Major Adverse 
      Cardiac Events in Young Patients with Acute ST Elevation Myocardial 
      Infarction-Added Value over Left Ventricular Myocardial Work Indices.
LID - 10.3390/diagnostics12081946 [doi]
LID - 1946
AB  - Acute ST elevation myocardial infarction (STEMI) remains a leading cause of 
      morbidity and mortality worldwide despite continuous advances in diagnostic, 
      prognostic and therapeutic methods. Myocardial work (MW) indices and miRNAs have 
      both emerged as potential prognostic markers in acute coronary syndromes in 
      recent years. In this study we aim to assess the prognostic role of myocardial 
      work indices and of a group of miRNAs in young patients with STEMI. We enrolled 
      50 young patients (<55 years) with STEMI who underwent primary PCI and 10 healthy 
      age-matched controls. We performed standard 2D and 3D echocardiography; we also 
      calculated left ventricular global longitudinal strain (GLS) and the derived 
      myocardial work indices. Using RT-PCR we determined the plasmatic levels of six 
      miRNAs: miR-223-3p, miR-142-3p, miR-146a-5p, miR-125a-5p, miR-486-5p and 
      miR-155-5p. We assessed the occurrence of major adverse cardiac events (MACE) at 
      up to one year after STEMI. Out of 50 patients, 18% experienced MACE at the 
      one-year follow-up. In a Cox univariate logistic regression analysis, myocardial 
      work indices were all significantly associated with MACE. The ROC analysis showed 
      that GWI, GCW and GWE as a group have a better predictive value for MACE than 
      each separately (AUC 0.951, p = 0.000). Patients with higher miRNAs values at 
      baseline (miR-223-3p, miR-142-3p and miR-146a-5p) appear to have a higher 
      probability of developing adverse events at 12 months of follow-up. ROC curves 
      outlined for each variable confirmed their good predictive value (AUC = 0.832, p 
      = 0.002 for miR-223-3p; AUC = 0.732, p = 0.031 for miR-142-3p and AUC = 0.848, p 
      = 0.001 for miR-146a-5p); the group of three miRNAs also proved to have a better 
      predictive value for MACE together than separately (AUC = 0.862). Moreover, 
      adding each of the miRNAs (miR-233, miR-142-3p and miR-146a-5p) or all together 
      over the myocardial work indices in the regression models improved their 
      prognostic value. In conclusion, both myocardial work indices (GWI, GCW and GWE) 
      and three miRNAs (miR-223-3p, miR-142-3p and miR-146a-5p) have the potential to 
      be used as prognostic markers for adverse events after acute myocardial 
      infarction. The combination of miRNAs and MW indices (measured at baseline) 
      rather than each separately has very good predictive value for MACE in young 
      STEMI patients (C-statistic 0.977).
FAU - Scarlatescu, Alina Ioana
AU  - Scarlatescu AI
AUID- ORCID: 0000-0003-2183-5771
AD  - Department of Cardiology, "Carol Davila" University of Medicine and Pharmacy, 
      050474 Bucharest, Romania.
AD  - Department of Cardiology, Clinical Emergency Hospital of Bucharest, 014461 
      Bucharest, Romania.
FAU - Barbalata, Teodora
AU  - Barbalata T
AD  - Lipidomics Department, Institute of Cellular Biology and Pathology "Nicolae 
      Simionescu" of the Romanian Academy, 8, B.P. Hasdeu Street, 050568 Bucharest, 
      Romania.
FAU - Sima, Anca Volumnia
AU  - Sima AV
AD  - Lipidomics Department, Institute of Cellular Biology and Pathology "Nicolae 
      Simionescu" of the Romanian Academy, 8, B.P. Hasdeu Street, 050568 Bucharest, 
      Romania.
FAU - Stancu, Camelia
AU  - Stancu C
AD  - Lipidomics Department, Institute of Cellular Biology and Pathology "Nicolae 
      Simionescu" of the Romanian Academy, 8, B.P. Hasdeu Street, 050568 Bucharest, 
      Romania.
FAU - Niculescu, Loredan Stefan
AU  - Niculescu LS
AUID- ORCID: 0000-0002-1394-9085
AD  - Lipidomics Department, Institute of Cellular Biology and Pathology "Nicolae 
      Simionescu" of the Romanian Academy, 8, B.P. Hasdeu Street, 050568 Bucharest, 
      Romania.
FAU - Micheu, Miruna Mihaela
AU  - Micheu MM
AUID- ORCID: 0000-0001-7201-3132
AD  - Department of Cardiology, Clinical Emergency Hospital of Bucharest, 014461 
      Bucharest, Romania.
LA  - eng
GR  - PN-III-P2-2.1-PED-2019-1897/Unitatea Executiva Pentru Finantarea Invatamantului 
      Superior a Cercetarii Dezvoltarii si Inovarii/
PT  - Journal Article
DEP - 20220812
PL  - Switzerland
TA  - Diagnostics (Basel)
JT  - Diagnostics (Basel, Switzerland)
JID - 101658402
PMC - PMC9406722
OTO - NOTNLM
OT  - MACE
OT  - STEMI
OT  - miRNA
OT  - myocardial work indices
OT  - young
COIS- The authors declare no conflict of interest.
EDAT- 2022/08/27 06:00
MHDA- 2022/08/27 06:01
PMCR- 2022/08/12
CRDT- 2022/08/26 01:10
PHST- 2022/07/12 00:00 [received]
PHST- 2022/07/28 00:00 [revised]
PHST- 2022/08/08 00:00 [accepted]
PHST- 2022/08/26 01:10 [entrez]
PHST- 2022/08/27 06:00 [pubmed]
PHST- 2022/08/27 06:01 [medline]
PHST- 2022/08/12 00:00 [pmc-release]
AID - diagnostics12081946 [pii]
AID - diagnostics-12-01946 [pii]
AID - 10.3390/diagnostics12081946 [doi]
PST - epublish
SO  - Diagnostics (Basel). 2022 Aug 12;12(8):1946. doi: 10.3390/diagnostics12081946.