PMID- 36012884
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220830
IS  - 2077-0383 (Print)
IS  - 2077-0383 (Electronic)
IS  - 2077-0383 (Linking)
VI  - 11
IP  - 16
DP  - 2022 Aug 9
TI  - Sex-Specific Cut-Off Values for Low Skeletal Muscle Mass to Identify Patients at 
      Risk for Treatment-Related Adverse Events in Head and Neck Cancer.
LID - 10.3390/jcm11164650 [doi]
LID - 4650
AB  - A low skeletal muscle index (SMI), defined with cut-off values, is a promising 
      predictor for adverse events (AEs) in head and neck squamous cell cancer (HNSCC) 
      patients. The aim was to generate sex-specific SMI cut-off values based on AE to 
      diagnose low SMI and to analyse the relationship between low SMI and AEs in HNSCC 
      patients. In this present study, HNSCC patients were prospectively included in a 
      large oncological data-biobank and SMI was retrospectively measured using 
      baseline neck scans. In total, 193 patients were included and were stratified 
      according to treatment modality: (chemo-)radiotherapy ((C)RT) (n = 135) and 
      surgery (n = 61). AE endpoints were based on the occurrence of clinically 
      relevant toxicities (Common Terminology Criteria for Adverse Events grade >/= III) 
      and postoperative complications (Clavien-Dindo Classification grade >/= II). 
      Sex-specific SMI cut-off values were generated with receiver operating 
      characteristic curves, based on the AE endpoints. The relationship of the 
      baseline characteristics and AEs was analysed with logistic regression analysis, 
      with AEs as the endpoint. Multivariable logistic analysis showed that low SMI (OR 
      3.33, 95%CI 1.41-7.85) and tumour stage (OR 3.45, 95%CI 1.28-9.29) were 
      significantly and independently associated to (C)RT toxicity. Low SMI was not 
      related to postoperative complications. To conclude, sex-specific SMI cut-off 
      values, were generated based on the occurrence of AEs. Low SMI and tumour stage 
      were independently related to (C)RT toxicity in HNSCC patients.
FAU - Zwart, Aniek T
AU  - Zwart AT
AUID- ORCID: 0000-0002-9770-4754
AD  - Department of Epidemiology, University Medical Centre Groningen, 9700 RB 
      Groningen, The Netherlands.
AD  - Department of Radiology, University Medical Centre Groningen, 9700 RB Groningen, 
      The Netherlands.
AD  - Department of Otolaryngology and Head and Neck Surgery, University Medical Centre 
      Groningen, 9700 RB Groningen, The Netherlands.
FAU - Portzgen, Wolf
AU  - Portzgen W
AUID- ORCID: 0000-0002-9368-2543
AD  - Department of Otolaryngology and Head and Neck Surgery, University Medical Centre 
      Groningen, 9700 RB Groningen, The Netherlands.
FAU - van Rijn-Dekker, Irene
AU  - van Rijn-Dekker I
AUID- ORCID: 0000-0002-2803-8997
AD  - Department of Radiotherapy, University Medical Centre Groningen, 9700 RB 
      Groningen, The Netherlands.
FAU - Sidorenkov, Grigory A
AU  - Sidorenkov GA
AUID- ORCID: 0000-0002-1926-8862
AD  - Department of Epidemiology, University Medical Centre Groningen, 9700 RB 
      Groningen, The Netherlands.
FAU - Dierckx, Rudi A J O
AU  - Dierckx RAJO
AD  - Department of Radiology, University Medical Centre Groningen, 9700 RB Groningen, 
      The Netherlands.
FAU - Steenbakkers, Roel J H M
AU  - Steenbakkers RJHM
AD  - Department of Radiotherapy, University Medical Centre Groningen, 9700 RB 
      Groningen, The Netherlands.
FAU - Wegner, Inge
AU  - Wegner I
AD  - Department of Otolaryngology and Head and Neck Surgery, University Medical Centre 
      Groningen, 9700 RB Groningen, The Netherlands.
FAU - van der Hoorn, Anouk
AU  - van der Hoorn A
AD  - Department of Radiology, University Medical Centre Groningen, 9700 RB Groningen, 
      The Netherlands.
FAU - de Bock, Geertruida H
AU  - de Bock GH
AUID- ORCID: 0000-0003-3104-4471
AD  - Department of Epidemiology, University Medical Centre Groningen, 9700 RB 
      Groningen, The Netherlands.
FAU - Halmos, Gyorgy B
AU  - Halmos GB
AUID- ORCID: 0000-0003-2460-2260
AD  - Department of Otolaryngology and Head and Neck Surgery, University Medical Centre 
      Groningen, 9700 RB Groningen, The Netherlands.
LA  - eng
GR  - Graduate School of Medical Sciences from the University of Groningen and 
      University Medical Centre Groningen./
GR  - Graduate School of Medical Sciences of the University of Groningen and University 
      Medical Centre Groningen/
PT  - Journal Article
DEP - 20220809
PL  - Switzerland
TA  - J Clin Med
JT  - Journal of clinical medicine
JID - 101606588
PMC - PMC9409908
OTO - NOTNLM
OT  - adverse events
OT  - cut-off
OT  - head and neck neoplasms
OT  - postoperative complication
OT  - sarcopenia
OT  - skeletal muscle mass
OT  - toxicity
COIS- The authors declare no conflict of interest.
EDAT- 2022/08/27 06:00
MHDA- 2022/08/27 06:01
PMCR- 2022/08/09
CRDT- 2022/08/26 01:26
PHST- 2022/05/06 00:00 [received]
PHST- 2022/07/15 00:00 [revised]
PHST- 2022/07/27 00:00 [accepted]
PHST- 2022/08/26 01:26 [entrez]
PHST- 2022/08/27 06:00 [pubmed]
PHST- 2022/08/27 06:01 [medline]
PHST- 2022/08/09 00:00 [pmc-release]
AID - jcm11164650 [pii]
AID - jcm-11-04650 [pii]
AID - 10.3390/jcm11164650 [doi]
PST - epublish
SO  - J Clin Med. 2022 Aug 9;11(16):4650. doi: 10.3390/jcm11164650.