PMID- 36012980
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20230308
IS  - 2077-0383 (Print)
IS  - 2077-0383 (Electronic)
IS  - 2077-0383 (Linking)
VI  - 11
IP  - 16
DP  - 2022 Aug 14
TI  - Outcomes of Laryngeal Cancer Surgery after Open Partial Horizontal Laryngectomies 
      with Lateral Cervical Approach.
LID - 10.3390/jcm11164741 [doi]
LID - 4741
AB  - Background: Open partial horizontal laryngectomies (OPHL) are one of the surgical 
      techniques used for the conservative management of laryngeal cancers. The aims of 
      this study are to analyze the oncological and functional results of a group of 
      patients affected by laryngeal squamous cell carcinoma (LSCC) treated with OPHL, 
      performed using a minimally invasive technique. Methods: This is a prospective 
      case-control study. We enrolled 17 consecutive patients with LSCC treated with 
      OPHL through a lateral cervical approach (LCA). Patients were evaluated using 
      their Penetration Aspiration Scale score (liquid, semiliquid and solid) and Voice 
      Handicap Index (VHI) at three different endpoints: 15 days (T1), 3 months (T2), 
      and 6 months (T2) after surgery. Results: The functional outcomes of the LCA are 
      stackable with that of the classical anterior cervical approach in terms of 
      respiration, swallowing, and speech. One-way ANOVA was performed to evaluate the 
      variances of PAS and VHI scores at the three different observation points. No 
      statistically significant differences were observed between OPHL- PAS scores for 
      liquid (p = 0.1) at the three different observation points. A statistically 
      significant improvement was observed in the OPHL- PAS score for semisolids and 
      solids (p < 0.00001) between T1 and T3 (p = 0.0001) and for solids between T2 and 
      T3 (p < 0.00001). The improvement of VHI-10 was statistically significative (p < 
      0.00001) at the three different observation points (T1-T2 and T2-T3). Conclusion: 
      The LCA is a potential approach for laryngeal surgery in selected cases. The 
      preoperative staging and planning are of the utmost importance to ensure 
      oncological radicality. The main advantage of this approach is the preservation 
      of the healthy tissues surrounding the larynx and the functional and oncological 
      outcomes are stackable with the classic anterior cervical approach.
FAU - Colizza, Andrea
AU  - Colizza A
AUID- ORCID: 0000-0002-0639-806X
AD  - Department of Sense Organs, Sapienza University of Rome, 00161 Roma, Italy.
FAU - Ralli, Massimo
AU  - Ralli M
AUID- ORCID: 0000-0001-8776-0421
AD  - Department of Sense Organs, Sapienza University of Rome, 00161 Roma, Italy.
FAU - Di Stadio, Arianna
AU  - Di Stadio A
AUID- ORCID: 0000-0001-5510-3814
AD  - Department GF Ingrassia, University of Catania, 95125 Catania, Italy.
FAU - Cambria, Francesca
AU  - Cambria F
AD  - Department of Sense Organs, Sapienza University of Rome, 00161 Roma, Italy.
FAU - Zoccali, Federica
AU  - Zoccali F
AD  - Department of Sense Organs, Sapienza University of Rome, 00161 Roma, Italy.
FAU - Cialente, Fabrizio
AU  - Cialente F
AUID- ORCID: 0000-0002-8776-1018
AD  - Department of Sense Organs, Sapienza University of Rome, 00161 Roma, Italy.
FAU - Angeletti, Diletta
AU  - Angeletti D
AD  - Department of Sense Organs, Sapienza University of Rome, 00161 Roma, Italy.
FAU - Greco, Antonio
AU  - Greco A
AD  - Department of Sense Organs, Sapienza University of Rome, 00161 Roma, Italy.
FAU - de Vincentiis, Marco
AU  - de Vincentiis M
AD  - Department of Sense Organs, Sapienza University of Rome, 00161 Roma, Italy.
LA  - eng
PT  - Journal Article
DEP - 20220814
PL  - Switzerland
TA  - J Clin Med
JT  - Journal of clinical medicine
JID - 101606588
PMC - PMC9410219
OTO - NOTNLM
OT  - anterior myocutaneous flap
OT  - laryngeal squamous cell carcinoma
OT  - lateral cervical approach
OT  - open partial horizontal laryngectomies
OT  - penetration aspiration scale
COIS- The authors declare no conflict of interest.
EDAT- 2022/08/27 06:00
MHDA- 2022/08/27 06:01
PMCR- 2022/08/14
CRDT- 2022/08/26 01:27
PHST- 2022/07/05 00:00 [received]
PHST- 2022/08/09 00:00 [revised]
PHST- 2022/08/11 00:00 [accepted]
PHST- 2022/08/26 01:27 [entrez]
PHST- 2022/08/27 06:00 [pubmed]
PHST- 2022/08/27 06:01 [medline]
PHST- 2022/08/14 00:00 [pmc-release]
AID - jcm11164741 [pii]
AID - jcm-11-04741 [pii]
AID - 10.3390/jcm11164741 [doi]
PST - epublish
SO  - J Clin Med. 2022 Aug 14;11(16):4741. doi: 10.3390/jcm11164741.