PMID- 36013990
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220830
IS  - 2076-2607 (Print)
IS  - 2076-2607 (Electronic)
IS  - 2076-2607 (Linking)
VI  - 10
IP  - 8
DP  - 2022 Aug 4
TI  - Oral Microbiota Profile in Patients with Anti-Neutrophil Cytoplasmic 
      Antibody-Associated Vasculitis.
LID - 10.3390/microorganisms10081572 [doi]
LID - 1572
AB  - Microbiota has been associated with autoimmune diseases, with nasal 
      Staphylococcus aureus being implicated in the pathogenesis of anti-neutrophil 
      cytoplasmic antibody-associated vasculitis (AAV). Little is known about the role 
      of oral microbiota in AAV. In this study, levels of IgG antibodies to 53 oral 
      bacterial species/subspecies were screened using immunoblotting in plasma/serum 
      in pre-symptomatic AAV-individuals (n = 85), matched controls, and established 
      AAV-patients (n = 78). Saliva microbiota from acute-AAV and controls was 
      sequenced from 16s rDNA amplicons. Information on dental status was extracted 
      from a national register. IgG levels against oral bacteria were lower in 
      established AAV versus pre-AAV and controls. Specifically, pre-AAV samples had, 
      compared to controls, a higher abundance of periodontitis-associated species 
      paralleling more signs of periodontitis in established AAV-patients than 
      controls. Saliva microbiota in acute-AAV showed higher within-sample diversity 
      but fewer detectable amplicon-sequence variants and taxa in their core microbiota 
      than controls. Acute-AAV was not associated with increased abundance of 
      periodontal bacteria but species in, e.g., Arthrospira, Staphylococcus, 
      Lactobacillus, and Scardovia. In conclusion, the IgG profiles against oral 
      bacteria differed between pre-AAV, established AAV, and controls, and microbiota 
      profiles between acute AAV and controls. The IgG shift from a pre-symptomatic 
      stage to established disease cooccurred with treatment of immunosuppression 
      and/or antibiotics.
FAU - Esberg, Anders
AU  - Esberg A
AUID- ORCID: 0000-0002-4430-8125
AD  - Department of Odontology, Umea University, 901 87 Umea, Sweden.
FAU - Johansson, Linda
AU  - Johansson L
AD  - Department of Public Health and Clinical Medicine/Rheumatology, Umea University, 
      901 85 Umea, Sweden.
FAU - Berglin, Ewa
AU  - Berglin E
AD  - Department of Public Health and Clinical Medicine/Rheumatology, Umea University, 
      901 85 Umea, Sweden.
FAU - Mohammad, Aladdin J
AU  - Mohammad AJ
AD  - Department of Clinical Sciences/Rheumatology, Lund University, 221 00 Lund, 
      Sweden.
AD  - Department of Medicine, University of Cambridge, Cambridge CB2 0SP, UK.
FAU - Jonsson, Andreas P
AU  - Jonsson AP
AD  - Department of Public Health and Clinical Medicine, Umea University, 901 85 Umea, 
      Sweden.
FAU - Dahlqvist, Johanna
AU  - Dahlqvist J
AUID- ORCID: 0000-0002-6283-644X
AD  - Department of Medical Sciences/Rheumatology, Uppsala University, 751 85 Uppsala, 
      Sweden.
AD  - Department of Medical Biochemistry and Microbiology, Uppsala University, 752 37 
      Uppsala, Sweden.
FAU - Stegmayr, Bernd
AU  - Stegmayr B
AUID- ORCID: 0000-0003-2694-7035
AD  - Department of Public Health and Clinical Medicine, Umea University, 901 85 Umea, 
      Sweden.
FAU - Johansson, Ingegerd
AU  - Johansson I
AUID- ORCID: 0000-0002-9227-8434
AD  - Department of Odontology, Umea University, 901 87 Umea, Sweden.
FAU - Rantapaa-Dahlqvist, Solbritt
AU  - Rantapaa-Dahlqvist S
AUID- ORCID: 0000-0001-8259-3863
AD  - Department of Public Health and Clinical Medicine/Rheumatology, Umea University, 
      901 85 Umea, Sweden.
LA  - eng
GR  - Vasculitis Foundation USA/
GR  - 2018-02551/Swedish Research Council/
GR  - King Gustaf V's 80-Year Fund/
GR  - Swedish Rheumatism Association/
GR  - Umea University/
GR  - (ALF)/Vasterbotten County Council/
PT  - Journal Article
DEP - 20220804
PL  - Switzerland
TA  - Microorganisms
JT  - Microorganisms
JID - 101625893
PMC - PMC9412476
OTO - NOTNLM
OT  - IgG
OT  - anti-neutrophil cytoplasmatic antibody-associated vasculitis
OT  - caries
OT  - granulomatosis with polyangiitis (GPA)
OT  - microscopic polyangiitis (MPA)
OT  - myeloperoxidase (MPO)-ANCA
OT  - oral microbiota
OT  - periodontal disease
OT  - proteinase 3 (PR3)-ANCA
OT  - vasculitis
COIS- The authors have declared no conflict of interest.
EDAT- 2022/08/27 06:00
MHDA- 2022/08/27 06:01
PMCR- 2022/08/04
CRDT- 2022/08/26 01:34
PHST- 2022/07/02 00:00 [received]
PHST- 2022/07/27 00:00 [revised]
PHST- 2022/08/02 00:00 [accepted]
PHST- 2022/08/26 01:34 [entrez]
PHST- 2022/08/27 06:00 [pubmed]
PHST- 2022/08/27 06:01 [medline]
PHST- 2022/08/04 00:00 [pmc-release]
AID - microorganisms10081572 [pii]
AID - microorganisms-10-01572 [pii]
AID - 10.3390/microorganisms10081572 [doi]
PST - epublish
SO  - Microorganisms. 2022 Aug 4;10(8):1572. doi: 10.3390/microorganisms10081572.