PMID- 36015244
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220830
IS  - 1999-4923 (Print)
IS  - 1999-4923 (Electronic)
IS  - 1999-4923 (Linking)
VI  - 14
IP  - 8
DP  - 2022 Aug 2
TI  - Polyhydroxyalkanoate Decelerates the Release of Paclitaxel from 
      Poly(lactic-co-glycolic acid) Nanoparticles.
LID - 10.3390/pharmaceutics14081618 [doi]
LID - 1618
AB  - Biodegradable nanoparticles (NPs) are preferred as drug carriers because of their 
      effectiveness in encapsulating drugs, ability to control drug release, and low 
      cytotoxicity. Although poly(lactide co-glycolide) (PLGA)-based NPs have been used 
      for controlled release strategies, they have some disadvantages. This study 
      describes an approach using biodegradable polyhydroxyalkanoate (PHA) to overcome 
      these challenges. By varying the amount of PHA, NPs were successfully fabricated 
      by a solvent evaporation method. The size range of the NPS ranged from 137.60 to 
      186.93 nm, and showed zero-order release kinetics of paclitaxel (PTX) for 7 h, 
      and more sustained release profiles compared with NPs composed of PLGA alone. 
      Increasing the amount of PHA improved the PTX loading efficiency of NPs. Overall, 
      these findings suggest that PHA can be used for designing polymeric nanocarriers, 
      which offer a potential strategy for the development of improved drug delivery 
      systems for sustained and controlled release.
FAU - Lee, Si Yeong
AU  - Lee SY
AD  - Department of Nanoscience and Engineering, Inje University, Gimhae 50834, Korea.
FAU - Kim, So Yun
AU  - Kim SY
AD  - Department of Nanoscience and Engineering, Inje University, Gimhae 50834, Korea.
FAU - Ku, Sook Hee
AU  - Ku SH
AD  - CJ CheilJedang, Suwon 16495, Korea.
FAU - Park, Eun Ji
AU  - Park EJ
AD  - College of Pharmacy, Inje University, Gimhae 50834, Korea.
FAU - Jang, Dong-Jin
AU  - Jang DJ
AD  - Department of Bio-Health Technology, College of Biomedical Science, Kangwon 
      National University, Chunchoen 24341, Korea.
FAU - Kim, Sung Tae
AU  - Kim ST
AUID- ORCID: 0000-0001-8852-0198
AD  - Department of Nanoscience and Engineering, Inje University, Gimhae 50834, Korea.
AD  - Department of Pharmaceutical Engineering, Inje University, Gimhae 50834, Korea.
FAU - Kim, Seong-Bo
AU  - Kim SB
AD  - Bio-Living Engineering Major, Global Leaders College, Yonsei University, Seoul 
      03722, Korea.
LA  - eng
GR  - 2021M3E5E6027201/Bio & Medical Technology Development Program of the National 
      Research Foundation (NRF), and the Ministry of Science & ICT/
PT  - Journal Article
DEP - 20220802
PL  - Switzerland
TA  - Pharmaceutics
JT  - Pharmaceutics
JID - 101534003
PMC - PMC9416746
OTO - NOTNLM
OT  - Poly(lactide co-glycolide)
OT  - drug release
OT  - nanoparticle
OT  - paclitaxel
OT  - polyhydroxyalkanoate
COIS- The authors declare no conflict of interest.
EDAT- 2022/08/27 06:00
MHDA- 2022/08/27 06:01
PMCR- 2022/08/02
CRDT- 2022/08/26 01:42
PHST- 2022/06/09 00:00 [received]
PHST- 2022/07/25 00:00 [revised]
PHST- 2022/07/28 00:00 [accepted]
PHST- 2022/08/26 01:42 [entrez]
PHST- 2022/08/27 06:00 [pubmed]
PHST- 2022/08/27 06:01 [medline]
PHST- 2022/08/02 00:00 [pmc-release]
AID - pharmaceutics14081618 [pii]
AID - pharmaceutics-14-01618 [pii]
AID - 10.3390/pharmaceutics14081618 [doi]
PST - epublish
SO  - Pharmaceutics. 2022 Aug 2;14(8):1618. doi: 10.3390/pharmaceutics14081618.