PMID- 36016630
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220827
IS  - 1178-7007 (Print)
IS  - 1178-7007 (Electronic)
IS  - 1178-7007 (Linking)
VI  - 15
DP  - 2022
TI  - Association of lncRNA LINC01173 Expression with Vitamin-D and Vitamin B12 Level 
      Among Type 2 Diabetes Patients.
PG  - 2535-2543
LID - 10.2147/DMSO.S369012 [doi]
AB  - BACKGROUND: Type 2 diabetes mellitus (T2DM) has risen to become the world's most 
      serious public health problem in recent years, and the role of long noncoding 
      RNAs (lncRNAs) in the onset and progression of T2DM, as well as special attention 
      to vitamins, has gotten a lot of attention recently. METHODS: The aim of the 
      study was to analyze lncRNA LINC01173 expression along with assessment of 
      vitamin-D and B12 among the T2DM cases. Quantitative RT-PCR was used to analyze 
      the expression of lncRNA LINC01173. Vitamin-D and B12 were analyzed by 
      chemiluminescence-based assay. RESULTS: The present study observed that the T2DM 
      cases had 6.67-fold increased lncRNA LINC01173 expression compared to healthy 
      controls. Expression of lncRNA LINC01173 was found to be associated with 
      hypertension (p=0.03), wound healing (p=0.04), and blurred vision (p<0.0001). It 
      was observed that the T2DM cases with vitamin-D deficiency had a significant 
      association with fasting glucose level (p=0.01) and HbA1C level (p=0.01) among 
      the T2DM cases. The association of lncRNA LINC01173 with vitamin-D was analyzed 
      and it was observed that the vitamin-D deficient cases had higher lncRNA 
      LINC01173 expression compared to insufficient T2DM cases (p=0.01) and sufficient 
      T2DM cases (p=0.0006). It was also observed that the T2DM cases with smoking had 
      a 8.33-fold lncRNA LINC01173 expression while non-smokers had a 5.43-fold lncRNA 
      LINC01173 expression (p<0.0001). CONCLUSION: The study concluded that the 
      increased lncRNA LINC01173 expression was observed to be linked with alteration 
      in vitamin-D level and smoking habit. Altered expression of lncRNA LINC01173 
      expression was linked with fasting glucose and HbA1C alteration. Collectively, 
      lncRNA LINC01173 expression, vitamin-D alteration, as well as smoking habit may 
      cause the disease severity and increase the pathogenesis of disease.
CI  - (c) 2022 Aladel et al.
FAU - Aladel, Alanoud
AU  - Aladel A
AUID- ORCID: 0000-0002-1441-607X
AD  - Department of Community Health Sciences, College of Applied Medical Sciences, 
      King Saud University, Riyadh, Saudi Arabia.
FAU - Verma, Amit K
AU  - Verma AK
AD  - Department of Biotechnology, Jamia Millia Islamia, New Delhi, India.
FAU - Dabeer, Sadaf
AU  - Dabeer S
AUID- ORCID: 0000-0002-0564-4185
AD  - Division of Endocrinology Metabolism, and Lipids, School of Medicine, Emory 
      University, Atlanta, GA, USA.
FAU - Ahmad, Irfan
AU  - Ahmad I
AUID- ORCID: 0000-0002-9500-4623
AD  - Department of Clinical Laboratory Sciences, College of Applied Medical Sciences, 
      King Khalid University, Abha, Saudi Arabia.
FAU - Alshahrani, Mohammad Y
AU  - Alshahrani MY
AD  - Department of Clinical Laboratory Sciences, College of Applied Medical Sciences, 
      King Khalid University, Abha, Saudi Arabia.
FAU - AboHassan, Mohammad S
AU  - AboHassan MS
AD  - Department of Clinical Laboratory Sciences, College of Applied Medical Sciences, 
      King Khalid University, Abha, Saudi Arabia.
FAU - Khan, Mohammad Idreesh
AU  - Khan MI
AD  - Department of Clinical Nutrition, College of Applied Health Sciences in Arras, 
      Qassim University, Buraidah, Saudi Arabia.
FAU - Almutairi, Malak Ghazi
AU  - Almutairi MG
AD  - Department of Nutrition, Almethnab General Hospital, Qassim Health Cluster, 
      Ministry of Health, Al Mithnab, Saudi Arabia.
FAU - Beg, Mirza Masroor Ali
AU  - Beg MMA
AUID- ORCID: 0000-0002-4519-721X
AD  - Faculty of Medicine, Alatoo International University, Bishkek, Kyrgyzstan.
AD  - Centre for Promotion of Medical Research, Bishkek, Kyrgyzstan.
LA  - eng
PT  - Journal Article
DEP - 20220819
PL  - New Zealand
TA  - Diabetes Metab Syndr Obes
JT  - Diabetes, metabolic syndrome and obesity : targets and therapy
JID - 101515585
PMC - PMC9397532
OTO - NOTNLM
OT  - diabetes
OT  - long noncoding RNA
OT  - vitamin-B12
OT  - vitamin-D
COIS- The authors declare that they have no conflicts of interest.
EDAT- 2022/08/27 06:00
MHDA- 2022/08/27 06:01
PMCR- 2022/08/19
CRDT- 2022/08/26 02:15
PHST- 2022/04/14 00:00 [received]
PHST- 2022/06/29 00:00 [accepted]
PHST- 2022/08/26 02:15 [entrez]
PHST- 2022/08/27 06:00 [pubmed]
PHST- 2022/08/27 06:01 [medline]
PHST- 2022/08/19 00:00 [pmc-release]
AID - 369012 [pii]
AID - 10.2147/DMSO.S369012 [doi]
PST - epublish
SO  - Diabetes Metab Syndr Obes. 2022 Aug 19;15:2535-2543. doi: 10.2147/DMSO.S369012. 
      eCollection 2022.