PMID- 36017025
OWN - NLM
STAT- MEDLINE
DCOM- 20220829
LR  - 20230728
IS  - 1555-4317 (Electronic)
IS  - 1555-4309 (Print)
IS  - 1555-4309 (Linking)
VI  - 2022
DP  - 2022
TI  - Application of Fluorescence In Situ Hybridization Assisted by Fluorescence 
      Microscope in Detection of Her2 Gene in Breast Cancer Patients.
PG  - 3087681
LID - 10.1155/2022/3087681 [doi]
LID - 3087681
AB  - In order to study the important factors for evaluating the prognosis of breast 
      cancer patients, a fluorescence microscopy-assisted fluorescence in situ 
      hybridization technique was proposed. Compared with other detection techniques, 
      fluorescence in situ hybridization (FISH) technology assisted by a fluorescence 
      microscope has gradually gained favor in related fields due to its advantages of 
      high detection specificity, high sensitivity, and strong experimental period. 
      Combined with the basic overview of fluorescence microscopy and FISH technology, 
      the advantages and application points of FISH technology assisted by fluorescence 
      microscopy in the detection of the Her2 gene in breast cancer patients were 
      studied and discussed. The results show that IHC can be used as the primary 
      screening for HER2 gene status detection; IHC (2+) and IHC (3+) have false 
      positives, which are related to chromosome 17 polysomy, so FISH should be done to 
      confirm the diagnosis.
CI  - Copyright (c) 2022 Fang Lu et al.
FAU - Lu, Fang
AU  - Lu F
AUID- ORCID: 0000-0003-2792-4580
AD  - Jilin Kingmed for Clinical Laboratory Co, Ltd., Changchun, Jilin 130000, China.
FAU - Zhou, Tingting
AU  - Zhou T
AUID- ORCID: 0000-0002-9968-6916
AD  - Jilin Kingmed for Clinical Laboratory Co, Ltd., Changchun, Jilin 130000, China.
FAU - Liu, Yan
AU  - Liu Y
AUID- ORCID: 0000-0002-6722-5269
AD  - Jilin Kingmed for Clinical Laboratory Co, Ltd., Changchun, Jilin 130000, China.
FAU - Song, Liying
AU  - Song L
AUID- ORCID: 0000-0002-7812-5896
AD  - Jilin Kingmed for Clinical Laboratory Co, Ltd., Changchun, Jilin 130000, China.
FAU - Zhang, Bin
AU  - Zhang B
AUID- ORCID: 0000-0002-2787-0087
AD  - Jilin Kingmed for Clinical Laboratory Co, Ltd., Changchun, Jilin 130000, China.
FAU - Li, Yuyan
AU  - Li Y
AUID- ORCID: 0000-0001-7923-3891
AD  - Jilin Kingmed for Clinical Laboratory Co, Ltd., Changchun, Jilin 130000, China.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Retracted Publication
DEP - 20220811
PL  - England
TA  - Contrast Media Mol Imaging
JT  - Contrast media & molecular imaging
JID - 101286760
RN  - EC 2.7.10.1 (Receptor, ErbB-2)
SB  - IM
RIN - Contrast Media Mol Imaging. 2023 Jul 19;2023:9763619. PMID: 37502543
MH  - Genes, erbB-2
MH  - Humans
MH  - In Situ Hybridization, Fluorescence/methods
MH  - Microscopy, Fluorescence
MH  - *Neoplasms
MH  - *Receptor, ErbB-2/genetics
PMC - PMC9388259
COIS- The authors declare that they have no conflicts of interest.
EDAT- 2022/08/27 06:00
MHDA- 2022/08/30 06:00
PMCR- 2022/08/11
CRDT- 2022/08/26 02:24
PHST- 2022/06/08 00:00 [received]
PHST- 2022/07/01 00:00 [revised]
PHST- 2022/07/25 00:00 [accepted]
PHST- 2022/08/26 02:24 [entrez]
PHST- 2022/08/27 06:00 [pubmed]
PHST- 2022/08/30 06:00 [medline]
PHST- 2022/08/11 00:00 [pmc-release]
AID - 10.1155/2022/3087681 [doi]
PST - epublish
SO  - Contrast Media Mol Imaging. 2022 Aug 11;2022:3087681. doi: 10.1155/2022/3087681. 
      eCollection 2022.