PMID- 36017263
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220827
IS  - 1664-462X (Print)
IS  - 1664-462X (Electronic)
IS  - 1664-462X (Linking)
VI  - 13
DP  - 2022
TI  - Network pharmacology analysis and experimental verification reveal the mechanism 
      of the traditional Chinese medicine YU-Pingfeng San alleviating allergic rhinitis 
      inflammatory responses.
PG  - 934130
LID - 10.3389/fpls.2022.934130 [doi]
LID - 934130
AB  - YU-Pingfeng San (YPFS) can regulate inflammatory response to alleviate the 
      symptoms of nasal congestion and runny rose in allergic rhinitis (AR). However, 
      the mechanism of action remains unclear. In this study, 30 active ingredients of 
      three effective herbs included in YPFS and 140 AR/YPFS-related genes were 
      identified by database analysis. Gene ontology (GO) and Kyoto Encyclopedia of 
      Genes and Genomes (KEGG) enrichment analysis showed that the targets were mainly 
      enriched in immune inflammatory-related biological processes and pathways. 
      Finally, three hub gene targeting epidermal growth factor receptor (EGFR), 
      mitogen-activated protein kinase 1 (MAPK1), and protein kinase B1 (AKT1) related 
      to YPFS and AR were identified by network pharmacology analysis. YPFS treatment 
      decreased the expression of EGFR, MAPK1, and AKT1 in ovalbumin (OVA)-induced AR 
      mice and impaired the production of inflammatory factors interleukin (IL)-4, 
      IL-5, and IL-13, thus alleviating immunoglobulin E (IgE) production and the 
      symptoms of scratching nose in AR. Through molecular docking analysis, we found 
      that the active ingredients decursin, anomalin, and wogonin of YPFS could bind to 
      EGFR, MAPK1, and AKT1 proteins. Moreover, decursin treatment impaired the 
      expression of IL-4 and IL-5 in human PBMCs. These results suggested that YPFS 
      could alleviate the AR inflammatory responses by targeting EGFR, MAPK1, and AKT1, 
      showing the mechanism of action of YPFS in AR treatment.
CI  - Copyright (c) 2022 Liu, Sun, Liu, Song, Song, Lu, Zhang, Song, Yang and Li.
FAU - Liu, Zhen
AU  - Liu Z
AD  - Department of Otorhinolaryngology, Head and Neck Surgery, Yantai Yuhuangding 
      Hospital, Qingdao University, Yantai, China.
AD  - Shandong Provincial Clinical Research Center for Otorhinolaryngologic Diseases, 
      Yantai, China.
FAU - Sun, Qi
AU  - Sun Q
AD  - Department of Otorhinolaryngology, Head and Neck Surgery, Yantai Yuhuangding 
      Hospital, Qingdao University, Yantai, China.
AD  - Shandong Provincial Clinical Research Center for Otorhinolaryngologic Diseases, 
      Yantai, China.
FAU - Liu, Xinyue
AU  - Liu X
AD  - Department of Otorhinolaryngology, Head and Neck Surgery, Yantai Yuhuangding 
      Hospital, Qingdao University, Yantai, China.
AD  - Shandong Provincial Clinical Research Center for Otorhinolaryngologic Diseases, 
      Yantai, China.
FAU - Song, Zheying
AU  - Song Z
AD  - Department of Otorhinolaryngology, Head and Neck Surgery, Yantai Yuhuangding 
      Hospital, Qingdao University, Yantai, China.
AD  - Shandong Provincial Clinical Research Center for Otorhinolaryngologic Diseases, 
      Yantai, China.
AD  - Clinical Medicine College, Weifang Medical University, Weifang, China.
FAU - Song, Fei
AU  - Song F
AD  - Department of Otorhinolaryngology, Head and Neck Surgery, Yantai Yuhuangding 
      Hospital, Qingdao University, Yantai, China.
AD  - Shandong Provincial Clinical Research Center for Otorhinolaryngologic Diseases, 
      Yantai, China.
AD  - Second Clinical Medicine College, Binzhou Medical University, Yantai, China.
FAU - Lu, Congxian
AU  - Lu C
AD  - Department of Otorhinolaryngology, Head and Neck Surgery, Yantai Yuhuangding 
      Hospital, Qingdao University, Yantai, China.
AD  - Shandong Provincial Clinical Research Center for Otorhinolaryngologic Diseases, 
      Yantai, China.
FAU - Zhang, Yu
AU  - Zhang Y
AD  - Department of Otorhinolaryngology, Head and Neck Surgery, Yantai Yuhuangding 
      Hospital, Qingdao University, Yantai, China.
AD  - Shandong Provincial Clinical Research Center for Otorhinolaryngologic Diseases, 
      Yantai, China.
FAU - Song, Xicheng
AU  - Song X
AD  - Department of Otorhinolaryngology, Head and Neck Surgery, Yantai Yuhuangding 
      Hospital, Qingdao University, Yantai, China.
AD  - Shandong Provincial Clinical Research Center for Otorhinolaryngologic Diseases, 
      Yantai, China.
FAU - Yang, Yujuan
AU  - Yang Y
AD  - Department of Otorhinolaryngology, Head and Neck Surgery, Yantai Yuhuangding 
      Hospital, Qingdao University, Yantai, China.
AD  - Shandong Provincial Clinical Research Center for Otorhinolaryngologic Diseases, 
      Yantai, China.
FAU - Li, Yumei
AU  - Li Y
AD  - Department of Otorhinolaryngology, Head and Neck Surgery, Yantai Yuhuangding 
      Hospital, Qingdao University, Yantai, China.
AD  - Shandong Provincial Clinical Research Center for Otorhinolaryngologic Diseases, 
      Yantai, China.
LA  - eng
PT  - Journal Article
DEP - 20220809
PL  - Switzerland
TA  - Front Plant Sci
JT  - Frontiers in plant science
JID - 101568200
PMC - PMC9396374
OTO - NOTNLM
OT  - YPFS
OT  - allergic rhinitis
OT  - decursin
OT  - hub genes
OT  - network pharmacology analysis
COIS- The authors declare that the research was conducted in the absence of any 
      commercial or financial relationships that could be construed as a potential 
      conflict of interest.
EDAT- 2022/08/27 06:00
MHDA- 2022/08/27 06:01
PMCR- 2022/01/01
CRDT- 2022/08/26 02:30
PHST- 2022/05/02 00:00 [received]
PHST- 2022/07/13 00:00 [accepted]
PHST- 2022/08/26 02:30 [entrez]
PHST- 2022/08/27 06:00 [pubmed]
PHST- 2022/08/27 06:01 [medline]
PHST- 2022/01/01 00:00 [pmc-release]
AID - 10.3389/fpls.2022.934130 [doi]
PST - epublish
SO  - Front Plant Sci. 2022 Aug 9;13:934130. doi: 10.3389/fpls.2022.934130. eCollection 
      2022.