PMID- 36018561
OWN - NLM
STAT- MEDLINE
DCOM- 20220915
LR  - 20220920
IS  - 1477-0539 (Electronic)
IS  - 1477-0520 (Linking)
VI  - 20
IP  - 35
DP  - 2022 Sep 14
TI  - Iron(III)-catalyzed alpha-cyanation and carbonylation with 2-pyridylacetonitrile: 
      divergent synthesis of alpha-amino nitriles and tetrahydroisoquinolinones.
PG  - 7031-7035
LID - 10.1039/d2ob01199a [doi]
AB  - Iron-catalyzed oxidative synthesis of N-aryl-substituted tetrahydroisoquinolines 
      (THIQs) toward tetrahydroisoquinoline-based derivatives is reported. A wide range 
      of alpha-amino nitriles and tetrahydroisoquinolinones are synthesized in moderate to 
      good yields. This approach involves a new organic nitrile source, a cheap iron 
      catalyst under an oxygen atmosphere, and temperature-controlled divergent 
      synthesis and features complete selectivity and operational simplicity.
FAU - Xu, Fan
AU  - Xu F
AD  - Key Laboratory of Organo-Pharmaceutical Chemistry of Jiangxi Province, Gannan 
      Normal University, Ganzhou, 341000, China. chenzwang2021@163.com.
FAU - Zhang, Fanglian
AU  - Zhang F
AD  - Key Laboratory of Organo-Pharmaceutical Chemistry of Jiangxi Province, Gannan 
      Normal University, Ganzhou, 341000, China. chenzwang2021@163.com.
FAU - Wang, Wenjia
AU  - Wang W
AD  - Key Laboratory of Organo-Pharmaceutical Chemistry of Jiangxi Province, Gannan 
      Normal University, Ganzhou, 341000, China. chenzwang2021@163.com.
FAU - Yao, Mingxu
AU  - Yao M
AD  - Key Laboratory of Organo-Pharmaceutical Chemistry of Jiangxi Province, Gannan 
      Normal University, Ganzhou, 341000, China. chenzwang2021@163.com.
FAU - Lin, Xing
AU  - Lin X
AD  - Key Laboratory of Organo-Pharmaceutical Chemistry of Jiangxi Province, Gannan 
      Normal University, Ganzhou, 341000, China. chenzwang2021@163.com.
FAU - Yang, Fang
AU  - Yang F
AD  - Key Laboratory of Organo-Pharmaceutical Chemistry of Jiangxi Province, Gannan 
      Normal University, Ganzhou, 341000, China. chenzwang2021@163.com.
FAU - Qian, Yiping
AU  - Qian Y
AD  - Key Laboratory of Organo-Pharmaceutical Chemistry of Jiangxi Province, Gannan 
      Normal University, Ganzhou, 341000, China. chenzwang2021@163.com.
FAU - Chen, Zhengwang
AU  - Chen Z
AUID- ORCID: 0000-0002-6795-9625
AD  - Key Laboratory of Organo-Pharmaceutical Chemistry of Jiangxi Province, Gannan 
      Normal University, Ganzhou, 341000, China. chenzwang2021@163.com.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20220914
PL  - England
TA  - Org Biomol Chem
JT  - Organic & biomolecular chemistry
JID - 101154995
RN  - 0 (Nitriles)
RN  - E1UOL152H7 (Iron)
SB  - IM
MH  - Catalysis
MH  - *Iron
MH  - Molecular Structure
MH  - *Nitriles
MH  - Oxidation-Reduction
EDAT- 2022/08/27 06:00
MHDA- 2022/09/16 06:00
CRDT- 2022/08/26 11:24
PHST- 2022/08/27 06:00 [pubmed]
PHST- 2022/09/16 06:00 [medline]
PHST- 2022/08/26 11:24 [entrez]
AID - 10.1039/d2ob01199a [doi]
PST - epublish
SO  - Org Biomol Chem. 2022 Sep 14;20(35):7031-7035. doi: 10.1039/d2ob01199a.