PMID- 36027691
OWN - NLM
STAT- MEDLINE
DCOM- 20220928
LR  - 20220930
IS  - 1872-6844 (Electronic)
IS  - 0920-1211 (Linking)
VI  - 186
DP  - 2022 Oct
TI  - Caloric restriction: Anti-inflammatory and antioxidant mechanisms against 
      epileptic seizures.
PG  - 107012
LID - S0920-1211(22)00163-2 [pii]
LID - 10.1016/j.eplepsyres.2022.107012 [doi]
AB  - Caloric restriction (CR) possesses different cellular mechanisms. Though there 
      are still gaps in the literature regarding its plausible beneficial effects, the 
      suggestion that this alternative therapy can improve the inflammatory and 
      antioxidant response to control epileptic seizures is explored throughout this 
      study. Epilepsy is the second most prevalent neurodegenerative disease in the 
      world. However, the appropriate mechanisms for it to be fully controlled are 
      still unknown. Neuroinflammation and oxidative stress promote epileptic seizures' 
      appearance and might even aggravate them. There is growing evidence that caloric 
      restriction has extensive anti-inflammatory and antioxidant properties. For 
      instance, nuclear factor erythroid 2-related factor 2 (Nrf2) and all-trans 
      retinoic acid (ATRA) have been proposed to induce antioxidant processes and 
      ulteriorly improve the disease progression. Caloric restriction can be an option 
      for those patients with refractory epilepsy since it allows for anti-inflammatory 
      and antioxidant properties to evolve within the brain areas involved.
CI  - Copyright (c) 2022 Elsevier B.V. All rights reserved.
FAU - Rubio, Carmen
AU  - Rubio C
AD  - Departamento de Neurofisiologia, Instituto Nacional de Neurologia y Neurocirugia, 
      Mexico.
FAU - Lopez-Lopez, Felipe
AU  - Lopez-Lopez F
AD  - Departamento de Neurofisiologia, Instituto Nacional de Neurologia y Neurocirugia, 
      Mexico; Facultad de Medicina, Universidad Autonoma de Baja California, Campus 
      Mexicali, Mexico.
FAU - Rojas-Hernandez, Daniel
AU  - Rojas-Hernandez D
AD  - Departamento de Neurofisiologia, Instituto Nacional de Neurologia y Neurocirugia, 
      Mexico; Universidad Autonoma Metropolitana, Unidad Xochimilco, Mexico.
FAU - Moreno, Wilhelm
AU  - Moreno W
AD  - Departamento de Neurofisiologia, Instituto Nacional de Neurologia y Neurocirugia, 
      Mexico; Escuela Superior de Medicina, Instituto Politecnico Nacional, Mexico.
FAU - Rodriguez-Quintero, Paola
AU  - Rodriguez-Quintero P
AD  - Departamento de Neurofisiologia, Instituto Nacional de Neurologia y Neurocirugia, 
      Mexico; Escuela Superior de Medicina, Instituto Politecnico Nacional, Mexico.
FAU - Rubio-Osornio, Moises
AU  - Rubio-Osornio M
AD  - Departamento de Neuroquimica, Instituto Nacional de Neurologia y Neurocirugia, 
      Mexico. Electronic address: ruomon@gmail.com.mx.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20220822
PL  - Netherlands
TA  - Epilepsy Res
JT  - Epilepsy research
JID - 8703089
RN  - 0 (Anti-Inflammatory Agents)
RN  - 0 (Antioxidants)
RN  - 0 (NF-E2-Related Factor 2)
RN  - 5688UTC01R (Tretinoin)
SB  - IM
MH  - Anti-Inflammatory Agents/pharmacology/therapeutic use
MH  - Antioxidants/pharmacology/therapeutic use
MH  - Caloric Restriction
MH  - *Epilepsy/drug therapy
MH  - Humans
MH  - NF-E2-Related Factor 2/metabolism
MH  - *Neurodegenerative Diseases
MH  - Oxidative Stress
MH  - Seizures/drug therapy
MH  - Tretinoin/pharmacology/therapeutic use
OTO - NOTNLM
OT  - Antioxidant
OT  - Caloric restriction
OT  - Epilepsy
OT  - Neuroinflammation
OT  - Nrf2
OT  - Oxidative stress
COIS- Conflict of interest None of the authors has any conflict of interest to 
      disclose. We confirm that we have read the journal's position on issues involved 
      in ethical publication and affirm that this report is consistent with the 
      guidelines.
EDAT- 2022/08/27 06:00
MHDA- 2022/09/28 06:00
CRDT- 2022/08/26 18:21
PHST- 2021/09/13 00:00 [received]
PHST- 2022/01/26 00:00 [revised]
PHST- 2022/08/13 00:00 [accepted]
PHST- 2022/08/27 06:00 [pubmed]
PHST- 2022/09/28 06:00 [medline]
PHST- 2022/08/26 18:21 [entrez]
AID - S0920-1211(22)00163-2 [pii]
AID - 10.1016/j.eplepsyres.2022.107012 [doi]
PST - ppublish
SO  - Epilepsy Res. 2022 Oct;186:107012. doi: 10.1016/j.eplepsyres.2022.107012. Epub 
      2022 Aug 22.