PMID- 36028153
OWN - NLM
STAT- MEDLINE
DCOM- 20230206
LR  - 20230206
IS  - 1953-8022 (Electronic)
IS  - 1246-7820 (Linking)
VI  - 30
IP  - 1
DP  - 2023 Feb
TI  - Don't neglect the rare adverse event with intravenous immunoglobulin: Hemolytic 
      anemia.
PG  - 11-15
LID - S1246-7820(22)00237-3 [pii]
LID - 10.1016/j.tracli.2022.08.144 [doi]
AB  - Intravenous immunoglobulin (IVIG) associated hemolytic anemia is an 
      under-recognized complication of IVIG therapy. The incidence of this adverse 
      event is not clear. Patients at high risk for IVIG-associated hemolytic anemia 
      include non-O blood group recipients and those undergoing high-dose 
      administration for inflammatory or autoimmune disorders. Here, two different 
      cases of IVIG-associated hemolytic anemia are demonstrated. The first patient, a 
      66 year-old male with Guillain-Barre syndrome, had a severe attack for which 
      erythrocyte replacement was required. Mild hemolysis was detected during IVIG 
      administration in the second patient, a 57 year-old female with chronic immune 
      thrombocytopenic purpura. Following IVIG termination, the hemolysis diminished 
      gradually. Although it is rare and often manageable, clinicians should be aware 
      of and monitor patients for hemolytic anemia following IVIG therapy.
CI  - Copyright (c) 2022 Societe francaise de transfusion sanguine (SFTS). Published by 
      Elsevier Masson SAS. All rights reserved.
FAU - Ucar, Ismail
AU  - Ucar I
AD  - Mersin City Hospital, Department of Rhemautology, Turkey.
FAU - Koyuncu, Mahmut Bakir
AU  - Koyuncu MB
AD  - Adana City Hospital, Department of Hematology, Turkey.
FAU - Solmaz, Ali Alper
AU  - Solmaz AA
AD  - Mersin City Hospital, Department of Internal Medicine, Turkey.
FAU - Ugurludogan, Adil Can
AU  - Ugurludogan AC
AD  - Mersin City Hospital, Department of Hematology, Turkey.
FAU - Mercan, Seda
AU  - Mercan S
AD  - Mersin City Hospital, Blood Bank, Turkey.
FAU - Kucuk, Mehmet
AU  - Kucuk M
AD  - Mersin City Hospital, Blood Bank, Turkey.
FAU - Unal, Tufan
AU  - Unal T
AD  - Mersin City Hospital, Blood Bank, Turkey.
FAU - Mazman, Semir
AU  - Mazman S
AD  - Mersin City Hospital, Department of Neurology, Turkey.
FAU - Atilla, Erden
AU  - Atilla E
AD  - Mersin City Hospital, Department of Hematology, Turkey. Electronic address: 
      erdenatilla@gmail.com.
LA  - eng
PT  - Case Reports
PT  - Journal Article
DEP - 20220823
PL  - France
TA  - Transfus Clin Biol
JT  - Transfusion clinique et biologique : journal de la Societe francaise de 
      transfusion sanguine
JID - 9423846
RN  - 0 (Immunoglobulins, Intravenous)
SB  - IM
MH  - Male
MH  - Female
MH  - Humans
MH  - Middle Aged
MH  - Aged
MH  - *Immunoglobulins, Intravenous/adverse effects
MH  - Hemolysis
MH  - *Anemia, Hemolytic/chemically induced
OTO - NOTNLM
OT  - Anti-A antibody
OT  - Anti-B antibody
OT  - Hemolytic anemia
OT  - Intravenous immunoglobulin
COIS- Conflict of Interest The authors declare no conflict of interest
EDAT- 2022/08/27 06:00
MHDA- 2023/02/07 06:00
CRDT- 2022/08/26 19:26
PHST- 2022/02/21 00:00 [received]
PHST- 2022/08/18 00:00 [revised]
PHST- 2022/08/19 00:00 [accepted]
PHST- 2022/08/27 06:00 [pubmed]
PHST- 2023/02/07 06:00 [medline]
PHST- 2022/08/26 19:26 [entrez]
AID - S1246-7820(22)00237-3 [pii]
AID - 10.1016/j.tracli.2022.08.144 [doi]
PST - ppublish
SO  - Transfus Clin Biol. 2023 Feb;30(1):11-15. doi: 10.1016/j.tracli.2022.08.144. Epub 
      2022 Aug 23.