PMID- 36028354
OWN - NLM
STAT- MEDLINE
DCOM- 20221220
LR  - 20230221
IS  - 1876-4738 (Electronic)
IS  - 0914-5087 (Linking)
VI  - 81
IP  - 2
DP  - 2023 Feb
TI  - Atrial fibrillation in patients with severe aortic stenosis.
PG  - 144-153
LID - S0914-5087(22)00206-4 [pii]
LID - 10.1016/j.jjcc.2022.08.006 [doi]
AB  - BACKGROUND: There has been no previous report evaluating the long impact of 
      atrial fibrillation (AF) on the clinical outcomes stratified by the initial 
      management [conservative or aortic valve replacement (AVR)] strategies of severe 
      aortic stenosis (AS). METHODS: We analyzed 3815 patients with severe AS enrolled 
      in the CURRENT AS registry. Patients with AF were defined as those having a 
      history of AF when severe AS was found on the index echocardiography. The primary 
      outcome measure was a composite of aortic valve-related death or hospitalization 
      for heart failure. RESULTS: The cumulative 5-year incidence of the primary 
      outcome measure was significantly higher in patients with AF than in those 
      without AF (44.2 % versus 33.2 %, HR 1.54, 95 % CI 1.35-1.76). After adjusting 
      for confounders, the risk of AF relative to no AF remained significant (HR 1.34, 
      95 % CI 1.16-1.56). The magnitude of excess adjusted risk of AF for the primary 
      outcome measure was greater in the initial AVR stratum (N = 1197, HR 1.95, 95 % 
      CI 1.36-2.78) than in the conservative stratum (N = 2618, HR 1.26, 95 % CI 
      1.08-1.47) with a significant interaction (p = 0.04). In patients with AF, there 
      was a significant excess adjusted risk of paroxysmal AF (N = 254) relative to 
      chronic AF (N = 528) for the primary outcome measure (HR 1.34, 95 % CI 
      1.01-1.78). CONCLUSIONS: In patients with severe AS, concomitant AF was 
      independently associated with worse clinical outcomes regardless of the initial 
      management strategies. In those patients with conservative strategy, paroxysmal 
      AF is stronger risk factor than chronic AF.
CI  - Copyright (c) 2022 Elsevier Ltd. All rights reserved.
FAU - Matsuda, Shintaro
AU  - Matsuda S
AD  - Department of Cardiovascular Medicine, Kyoto University Graduate School of 
      Medicine, Kyoto, Japan.
FAU - Kato, Takao
AU  - Kato T
AD  - Department of Cardiovascular Medicine, Kyoto University Graduate School of 
      Medicine, Kyoto, Japan. Electronic address: tkato75@kuhp.kyoto-u.ac.jp.
FAU - Morimoto, Takeshi
AU  - Morimoto T
AD  - Department of Clinical Epidemiology, Hyogo College of Medicine, Nishinomiya, 
      Japan.
FAU - Taniguchi, Tomohiko
AU  - Taniguchi T
AD  - Department of Cardiovascular Medicine, Kobe City Medical Center General Hospital, 
      Kobe, Japan.
FAU - Minamino-Muta, Eri
AU  - Minamino-Muta E
AD  - Department of Cardiovascular Medicine, Kyoto University Graduate School of 
      Medicine, Kyoto, Japan.
FAU - Matsuda, Mitsuo
AU  - Matsuda M
AD  - Department of Cardiology, Kishiwada City Hospital, Kishiwada, Japan.
FAU - Shiomi, Hiroki
AU  - Shiomi H
AD  - Department of Cardiovascular Medicine, Kyoto University Graduate School of 
      Medicine, Kyoto, Japan.
FAU - Ando, Kenji
AU  - Ando K
AD  - Department of Cardiology, Kokura Memorial Hospital, Kokura, Japan.
FAU - Shirai, Shinichi
AU  - Shirai S
AD  - Department of Cardiology, Kokura Memorial Hospital, Kokura, Japan.
FAU - Kanamori, Norio
AU  - Kanamori N
AD  - Division of Cardiology, Shimada Municipal Hospital, Shimada, Japan.
FAU - Murata, Koichiro
AU  - Murata K
AD  - Department of Cardiology, Shizuoka City Shizuoka Hospital, Shizuoka, Japan.
FAU - Kitai, Takeshi
AU  - Kitai T
AD  - Department of Cardiovascular Medicine, National Cerebral and Cardiovascular 
      Center Hospital, Suita, Japan.
FAU - Kawase, Yuichi
AU  - Kawase Y
AD  - Department of Cardiovascular Medicine, Kurashiki Central Hospital, Kurashiki, 
      Japan.
FAU - Izumi, Chisato
AU  - Izumi C
AD  - Department of Cardiovascular Medicine, National Cerebral and Cardiovascular 
      Center Hospital, Suita, Japan.
FAU - Miyake, Makoto
AU  - Miyake M
AD  - Department of Cardiology, Tenri Hospital, Tenri, Japan.
FAU - Mitsuoka, Hirokazu
AU  - Mitsuoka H
AD  - Division of Cardiology, Kindai University Nara Hospital, Ikoma, Japan.
FAU - Kato, Masashi
AU  - Kato M
AD  - Department of Cardiology, Mitsubishi Kyoto Hospital, Kyoto, Japan.
FAU - Hirano, Yutaka
AU  - Hirano Y
AD  - Department of Cardiology, Kindai University Hospital, Osakasayama, Japan.
FAU - Nagao, Kazuya
AU  - Nagao K
AD  - Department of Cardiovascular Center, Osaka Red Cross Hospital, Osaka, Japan.
FAU - Inada, Tsukasa
AU  - Inada T
AD  - Department of Cardiovascular Center, Osaka Red Cross Hospital, Osaka, Japan.
FAU - Mabuchi, Hiroshi
AU  - Mabuchi H
AD  - Department of Cardiology, Koto Memorial Hospital, Higashiomi, Japan.
FAU - Takeuchi, Yasuyo
AU  - Takeuchi Y
AD  - Department of Cardiology, Shizuoka General Hospital, Shizuoka, Japan.
FAU - Yamane, Keiichiro
AU  - Yamane K
AD  - Department of Cardiology, Kobe City Nishi-Kobe Medical Center, Kobe, Japan.
FAU - Toyofuku, Mamoru
AU  - Toyofuku M
AD  - Department of Cardiology, Japanese Red Cross Wakayama Medical Center, Wakayama, 
      Japan.
FAU - Ishii, Mitsuru
AU  - Ishii M
AD  - Department of Cardiology, National Hospital Organization Kyoto Medical Center, 
      Kyoto, Japan.
FAU - Inoko, Moriaki
AU  - Inoko M
AD  - Cardiovascular Center, The Tazuke Kofukai Medical Research Institute, Kitano 
      Hospital, Osaka, Japan.
FAU - Ikeda, Tomoyuki
AU  - Ikeda T
AD  - Department of Cardiology, Hikone Municipal Hospital, Hikone, Japan.
FAU - Komasa, Akihiro
AU  - Komasa A
AD  - Department of Cardiovascular Medicine, Kyoto University Graduate School of 
      Medicine, Kyoto, Japan.
FAU - Ishii, Katsuhisa
AU  - Ishii K
AD  - Department of Cardiology, Kansai Electric Power Hospital, Osaka, Japan.
FAU - Hotta, Kozo
AU  - Hotta K
AD  - Department of Cardiology, Hyogo Prefectural Amagasaki General Medical Center, 
      Amagasaki, Japan.
FAU - Higashitani, Nobuya
AU  - Higashitani N
AD  - Department of Cardiology, Japanese Red Cross Otsu Hospital, Otsu, Japan.
FAU - Jinnai, Toshikazu
AU  - Jinnai T
AD  - Department of Cardiology, Japanese Red Cross Otsu Hospital, Otsu, Japan.
FAU - Kato, Yoshihiro
AU  - Kato Y
AD  - Department of Cardiology, Saiseikai Noe Hospital, Osaka, Japan.
FAU - Inuzuka, Yasutaka
AU  - Inuzuka Y
AD  - Department of Cardiology, Shiga General Hospital, Moriyama, Japan.
FAU - Morikami, Yuko
AU  - Morikami Y
AD  - Department of Cardiology, Hirakata Kohsai Hospital, Hirakata, Japan.
FAU - Saito, Naritatsu
AU  - Saito N
AD  - Department of Cardiovascular Medicine, Kyoto University Graduate School of 
      Medicine, Kyoto, Japan.
FAU - Minatoya, Kenji
AU  - Minatoya K
AD  - Department of Cardiovascular Surgery, Kyoto University Graduate School of 
      Medicine, Kyoto, Japan.
FAU - Kimura, Takeshi
AU  - Kimura T
AD  - Department of Cardiovascular Medicine, Kyoto University Graduate School of 
      Medicine, Kyoto, Japan.
LA  - eng
PT  - Journal Article
DEP - 20220823
PL  - Netherlands
TA  - J Cardiol
JT  - Journal of cardiology
JID - 8804703
SB  - IM
MH  - Humans
MH  - *Atrial Fibrillation/complications/epidemiology
MH  - *Aortic Valve Stenosis/complications/diagnostic imaging/epidemiology
MH  - *Heart Valve Prosthesis Implantation/adverse effects
MH  - Treatment Outcome
MH  - Aortic Valve/surgery
MH  - Risk Factors
MH  - *Transcatheter Aortic Valve Replacement/adverse effects
OTO - NOTNLM
OT  - Aortic stenosis
OT  - Aortic valve replacement
OT  - Atrial fibrillation
OT  - Heart failure
OT  - Transcatheter aortic valve implantation
EDAT- 2022/08/27 06:00
MHDA- 2022/12/21 06:00
CRDT- 2022/08/26 22:04
PHST- 2022/04/25 00:00 [received]
PHST- 2022/07/01 00:00 [revised]
PHST- 2022/08/03 00:00 [accepted]
PHST- 2022/08/27 06:00 [pubmed]
PHST- 2022/12/21 06:00 [medline]
PHST- 2022/08/26 22:04 [entrez]
AID - S0914-5087(22)00206-4 [pii]
AID - 10.1016/j.jjcc.2022.08.006 [doi]
PST - ppublish
SO  - J Cardiol. 2023 Feb;81(2):144-153. doi: 10.1016/j.jjcc.2022.08.006. Epub 2022 Aug 
      23.